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Gene Review:

PSG2 - pregnancy specific beta-1-glycoprotein 2

Homo sapiens

Synonyms: CEA, PS-beta-E, PS-beta-G-2, PSBG-2, PSBG2, ...

Fanfulla, F. et al., Hoffhines, A.J. et al., Sanders, M.H. et al., Lei, K.J. et al., Zoubir, F. et al.

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Disease relevance of PSG2

In general, individuals with satisfactory amelioration of sleep-disordered breathing on PSG 2 demonstrated similar improvement on PSG 3 [1].

Psychiatry related information on PSG2

PSG1 was representative of PSGtot and similar to PSG2 only in those patients with rapid eye movement (REM) phase sleep in the first part of the night [2].

High impact information on PSG2

We have developed a novel anti-sulfotyrosine monoclonal antibody (called PSG2) that binds with high affinity and exquisite specificity to sulfotyrosine residues in peptides and proteins independently of sequence context [3].
PSG1, which lacks exon 1 (5'/L), but contains exons 2 (L/N), 3 (A1), 4 (A2), and 5 (B2-C), encodes five previously identified type I transcripts, PSG1a, 1b, 1c, 1d, and 1e in a L/N-A1-A2-B2-C domain arrangement [4].
A significant difference was found between apnoea-hypopnoea indices (AHI) recorded in PSG1, PSG2 and PSGtot (mean+/-SD, AHI1 33+/-27, AHI2 45+/-28, AHItot 40+/-25 events x h(-1), respectively; p<0.01) [2].
SG5 is identical to PSG3, and SG9 to PSG1d, while SG8 most probably corresponds to PSG2 [5].
During non-REM sleep the A + H/I on PSG 3 (29 +/- 10) was lower than it was on PSG 2 (54.3 +/- 11.3) (p = 0.004) and lower than that on PSG 1 (70.8 +/- 10.3) (p = 0.003) [1].

Analytical, diagnostic and therapeutic context of PSG2

Twenty nine consecutive OSAS patients, aged 54+/-10 yrs; body mass index (BMI) 40+/-6 kg x m(-2) (mean+/-SD values), were studied by separate analyses of PSG1, PSG2 and PSGtot [2].
Finally, Western blot analysis using PSG2 showed that certain sperm/epididymal proteins are undersulfated in Tpst2(-/-) mice [3].

References

Polysomnography early after uvulopalatopharyngoplasty as a predictor of late postoperative results. Sanders, M.H., Costantino, J.P., Johnson, J.T. Chest (1990) [Pubmed]
Obstructive sleep apnoea syndrome: is the "half-night polysomnography" an adequate method for evaluating sleep profile and respiratory events? Fanfulla, F., Patruno, V., Bruschi, C., Rampulla, C. Eur. Respir. J. (1997) [Pubmed]
Detection and Purification of Tyrosine-sulfated Proteins Using a Novel Anti-sulfotyrosine Monoclonal Antibody. Hoffhines, A.J., Damoc, E., Bridges, K.G., Leary, J.A., Moore, K.L. J. Biol. Chem. (2006) [Pubmed]
Cloning and expression of genes encoding human pregnancy-specific glycoproteins. Lei, K.J., Sartwell, A.D., Pan, C.J., Chou, J.Y. J. Biol. Chem. (1992) [Pubmed]
Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning. Zoubir, F., Khan, W.N., Hammarström, S. Biochem. Biophys. Res. Commun. (1990) [Pubmed]

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