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Gene Review

PSG2  -  pregnancy specific beta-1-glycoprotein 2

Homo sapiens

Synonyms: CEA, PS-beta-E, PS-beta-G-2, PSBG-2, PSBG2, ...
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Disease relevance of PSG2


Psychiatry related information on PSG2

  • PSG1 was representative of PSGtot and similar to PSG2 only in those patients with rapid eye movement (REM) phase sleep in the first part of the night [2].

High impact information on PSG2

  • We have developed a novel anti-sulfotyrosine monoclonal antibody (called PSG2) that binds with high affinity and exquisite specificity to sulfotyrosine residues in peptides and proteins independently of sequence context [3].
  • PSG1, which lacks exon 1 (5'/L), but contains exons 2 (L/N), 3 (A1), 4 (A2), and 5 (B2-C), encodes five previously identified type I transcripts, PSG1a, 1b, 1c, 1d, and 1e in a L/N-A1-A2-B2-C domain arrangement [4].
  • A significant difference was found between apnoea-hypopnoea indices (AHI) recorded in PSG1, PSG2 and PSGtot (mean+/-SD, AHI1 33+/-27, AHI2 45+/-28, AHItot 40+/-25 events x h(-1), respectively; p<0.01) [2].
  • SG5 is identical to PSG3, and SG9 to PSG1d, while SG8 most probably corresponds to PSG2 [5].
  • During non-REM sleep the A + H/I on PSG 3 (29 +/- 10) was lower than it was on PSG 2 (54.3 +/- 11.3) (p = 0.004) and lower than that on PSG 1 (70.8 +/- 10.3) (p = 0.003) [1].

Analytical, diagnostic and therapeutic context of PSG2

  • Twenty nine consecutive OSAS patients, aged 54+/-10 yrs; body mass index (BMI) 40+/-6 kg x m(-2) (mean+/-SD values), were studied by separate analyses of PSG1, PSG2 and PSGtot [2].
  • Finally, Western blot analysis using PSG2 showed that certain sperm/epididymal proteins are undersulfated in Tpst2(-/-) mice [3].


  1. Polysomnography early after uvulopalatopharyngoplasty as a predictor of late postoperative results. Sanders, M.H., Costantino, J.P., Johnson, J.T. Chest (1990) [Pubmed]
  2. Obstructive sleep apnoea syndrome: is the "half-night polysomnography" an adequate method for evaluating sleep profile and respiratory events? Fanfulla, F., Patruno, V., Bruschi, C., Rampulla, C. Eur. Respir. J. (1997) [Pubmed]
  3. Detection and Purification of Tyrosine-sulfated Proteins Using a Novel Anti-sulfotyrosine Monoclonal Antibody. Hoffhines, A.J., Damoc, E., Bridges, K.G., Leary, J.A., Moore, K.L. J. Biol. Chem. (2006) [Pubmed]
  4. Cloning and expression of genes encoding human pregnancy-specific glycoproteins. Lei, K.J., Sartwell, A.D., Pan, C.J., Chou, J.Y. J. Biol. Chem. (1992) [Pubmed]
  5. Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning. Zoubir, F., Khan, W.N., Hammarström, S. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
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