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Gene Review:

PSG3 - pregnancy specific beta-1-glycoprotein 3

Homo sapiens

Synonyms: Carcinoembryonic antigen SG5, PS-beta-G-3, PSBG-3, Pregnancy-specific beta-1-glycoprotein 3, Pregnancy-specific glycoprotein 3

Tokita, S. et al., Sanders, M.H. et al., Wu, S.M. et al., García, J. et al., Zoubir, F. et al.

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Disease relevance of PSG3

In general, individuals with satisfactory amelioration of sleep-disordered breathing on PSG 2 demonstrated similar improvement on PSG 3 [1].

High impact information on PSG3

Since neither neuraminidase- nor endoglycopeptidase F-treatment of GPIIIa had any significant effect on the binding of PSG3, this array must be located within the amino acid sequence of GPIIIa but not in the carbohydrate moiety [2].
PSG3 inhibited platelet aggregation induced by either ADP or collagen, it also inhibited fibrinogen binding to activated platelets in a dose-dependent fashion [2].
PSG3, however, did not inhibit the binding of GRGDSP peptide to activated platelets [2].
PSG3 bound also to certain polyanionic substances, such as double-stranded DNA, heparan sulfate, dextran sulfate and acetylated-LDL, but not to other polyanionic substances [2].
These results suggest that PSG1 and PSG3 exhibit embryotropic activity at different stages of development in the mouse model [3].

Anatomical context of PSG3

Two-cell stage mouse embryos were co-cultured in a two-chamber system with CHO cells expressing either recombinant PSG1 (rPSG1) or PSG3 (rPSG3) in the presence and absence of neutralizing PSG antibodies [3].

Associations of PSG3 with chemical compounds

We identified an IgG anti-PL mAb, designated PSG3, which cross-reacted specifically with glycoprotein (GP) IIIa in human platelets and inhibited platelet aggregation [2].

Other interactions of PSG3

SG5 is identical to PSG3, and SG9 to PSG1d, while SG8 most probably corresponds to PSG2 [4].
The nadir of SaO2 during non-REM sleep was higher during PSG 3 than during PSG 1 (p = 0.002), but not different from that on PSG 2 [1].
These results suggest that the PSG3 epitope on GPIIIa contains a particular array of negative charges, and possibly affects the fibrinogen binding to GPIIb/IIIa complex necessary for platelet aggregation [2].
The other 17 sequences showed high similarity to known human genes (like PSG3, FN1, PAI-2) [5].

Analytical, diagnostic and therapeutic context of PSG3

Patients who did not have a substantial improvement in the early postoperative period often had improvement on PSG 3, but there was a good deal of interindividual variability in this regard [1].

References

Polysomnography early after uvulopalatopharyngoplasty as a predictor of late postoperative results. Sanders, M.H., Costantino, J.P., Johnson, J.T. Chest (1990) [Pubmed]
Specific cross-reaction of IgG anti-phospholipid antibody with platelet glycoprotein IIIa. Tokita, S., Arai, M., Yamamoto, N., Katagiri, Y., Tanoue, K., Igarashi, K., Umeda, M., Inoue, K. Thromb. Haemost. (1996) [Pubmed]
Effect of pregnancy-specific beta 1-glycoprotein on the development of preimplantation embryo. Wu, S.M., Arnold, L.L., Rone, J., Trivadi, M., Chan, W.Y. Proc. Soc. Exp. Biol. Med. (1999) [Pubmed]
Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning. Zoubir, F., Khan, W.N., Hammarström, S. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
Differential display RT-PCR analysis of human choriocarcinoma cell lines and normal term trophoblast cells: identification of new genes expressed in placenta. García, J., Castrillo, J.L. Placenta (2004) [Pubmed]

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