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Chemical Compound Review

Sulfotyrosine     1-[(2S)-2-amino-2- sulfooxycarbonyl-ethyl]...

Synonyms: AC1L3XDA, UNII-29166358BF, Tyrosine sulfate, tyrosine O-sulfate, L-Tyrosine, hydrogen sulfate (ester)
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Disease relevance of L-Tyrosine O-sulfate


High impact information on L-Tyrosine O-sulfate


Biological context of L-Tyrosine O-sulfate


Anatomical context of L-Tyrosine O-sulfate

  • A similar tyrosine-O-sulfate-binding protein was also detected in the choleate extracts of the Golgi-enriched microsomal membrane fractions prepared from bovine pancreas and from both liver and pancreas of dog [9].

Associations of L-Tyrosine O-sulfate with other chemical compounds


Gene context of L-Tyrosine O-sulfate


Analytical, diagnostic and therapeutic context of L-Tyrosine O-sulfate


  1. Isolation of tyrosine-O-sulfate by Pronase hydrolysis from fibronectin secreted by Fujinami sarcoma virus-infected rat fibroblasts. Liu, M.C., Lipmann, F. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  2. Decrease of tyrosine-O-sulfate-containing proteins found in rat fibroblasts infected with Rous sarcoma virus or Fujinami sarcoma virus. Liu, M.C., Lipmann, F. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  3. Using Phage Display to Select Antibodies Recognizing Post-translational Modifications Independently of Sequence Context. Kehoe, J.W., Velappan, N., Walbolt, M., Rasmussen, J., King, D., Lou, J., Knopp, K., Pavlik, P., Marks, J.D., Bertozzi, C.R., Bradbury, A.R. Mol. Cell Proteomics (2006) [Pubmed]
  4. Tyramine-O-sulfate, in addition to tyrosine-O-sulfate, is produced and secreted by HepG2 human hepatoma cells, but not by 3Y1 rat embryo fibroblasts. Liu, M.C., Yu, S., Suiko, M. Biochem. Int. (1990) [Pubmed]
  5. A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding. Sako, D., Comess, K.M., Barone, K.M., Camphausen, R.T., Cumming, D.A., Shaw, G.D. Cell (1995) [Pubmed]
  6. Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence. Seibert, C., Cadene, M., Sanfiz, A., Chait, B.T., Sakmar, T.P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. Aspartic acid residues 72 and 75 and tyrosine-sulfate 73 of heparin cofactor II promote intramolecular interactions during glycosaminoglycan binding and thrombin inhibition. Mitchell, J.W., Church, F.C. J. Biol. Chem. (2002) [Pubmed]
  8. Post-translational modification of the fourth component of complement. Sulfation of the alpha-chain. Karp, D.R. J. Biol. Chem. (1983) [Pubmed]
  9. Isolation and characterization of a bovine liver tyrosine-O-sulfate-binding protein--a putative receptor molecular for tyrosine-sulfated proteins? Liu, M.C., Suiko, M., Tang, X.B. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  10. Recognition of a CXCR4 sulfotyrosine by the chemokine stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12). Veldkamp, C.T., Seibert, C., Peterson, F.C., Sakmar, T.P., Volkman, B.F. J. Mol. Biol. (2006) [Pubmed]
  11. Chlorate inhibits tyrosine sulfation of human type III procollagen without affecting its secretion or processing. Jukkola, A., Risteli, J., Risteli, L. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  12. Structure, modelling, and molecular dynamics studies of the inhibition of protein tyrosine phosphatase 1B by sulfotyrosine peptides. Glover, N.R., Tracey, A.S. Biochem. Cell Biol. (1999) [Pubmed]
  13. Identification and characterization of a major bovine serum tyrosine-O-sulfate-binding protein as a complement factor H. Sakakibara, Y., Suiko, M., Fernando, P.H., Ohashi, T., Liu, M.C. Cytotechnology. (1994) [Pubmed]
  14. Synthesis of cholecystokinin-related peptides and their biological properties. Wünsch, E., Moroder, L., Lerchen, H.G., Christophe, J., Svoboda, M. Biol. Chem. Hoppe-Seyler (1989) [Pubmed]
  15. Polyomavirus major capsid protein VP1 is modified by tyrosine sulfuration. Ludlow, J.W., Consigli, R.A. J. Virol. (1987) [Pubmed]
  16. Presence of tyrosine-O-sulfate in sheep pituitary prolactin. Kohli, R., Chadha, N., Muralidhar, K. FEBS Lett. (1988) [Pubmed]
  17. Structure-function relationships in heparin cofactor II: spectral analysis of aromatic residues and absence of a role for sulfhydryl groups in thrombin inhibition. Church, F.C., Meade, J.B., Pratt, C.W. Arch. Biochem. Biophys. (1987) [Pubmed]
  18. Change in binding affinities of 3Y1 secreted fibronectin upon desulfation of tyrosine-O-sulfate. Suiko, M., Liu, M.C. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  19. Quantitation of tyrosine-O-sulfate in human urine by ion-pair reverse-phase high-performance liquid chromatography. Suiko, M., Fernando, P.H., Arino, Y., Terada, M., Nakatsu, S., Liu, M.C. Clin. Chim. Acta (1990) [Pubmed]
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