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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

BBX  -  bobby sox homolog (Drosophila)

Homo sapiens

Synonyms: ARTC1, Bobby sox homolog, HBP2, HMG box transcription factor BBX, HMG box-containing protein 2, ...
 
 
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High impact information on BBX

  • The negative control polymers showed little to no initial cell attachment, and the addition of soluble heparin to the medium reduced initial cell adhesion on both the HBP2 and HBP2:RGD surfaces [1].
  • The relationship of WZF1 and HBP-2 and the possible role of WZF1 in the histone gene expression were discussed [2].
  • These tick proteins have been assigned to the tick lipocalin family based on database searches that indicated homology between tick sequences and the fact that the histamine binding protein (HBP2) from the hard tick Rhipicephalus appendiculatus (Ixodidae) shows structural similarity to the lipocalin fold [3].
  • The mammalian HBP2 gene has been isolated by functional complementation of cells unable to undergo DNA replication in fission yeast [4].
  • This review examines the clinical experience from the MDS-001 and MDS-003 clinical trials that led to this approval, the results of biological correlates supporting the targets of drug action, and the results from a non-del(5q) multicenter study (MDS-002) [5].

References

  1. Human endothelial cell interaction with biomimetic surfactant polymers containing Peptide ligands from the heparin binding domain of fibronectin. Sagnella, S., Anderson, E., Sanabria, N., Marchant, R.E., Kottke-Marchant, K. Tissue engineering. (2005) [Pubmed]
  2. The putative zinc-finger protein WZF1 interacts with a cis-acting element of wheat histone genes. Sakamoto, A., Minami, M., Huh, G.H., Iwabuchi, M. Eur. J. Biochem. (1993) [Pubmed]
  3. Exon-intron structure of outlier tick lipocalins indicate a monophyletic origin within the larger lipocalin family. Mans, B.J., Neitz, A.W. Insect Biochem. Mol. Biol. (2004) [Pubmed]
  4. HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex. Sánchez-Díaz, A., Blanco, M.A., Jones, N., Moreno, S. Curr. Genet. (2001) [Pubmed]
  5. Lenalidomide: targeted anemia therapy for myelodysplastic syndromes. List, A.F., Baker, A.F., Green, S., Bellamy, W. Cancer control : journal of the Moffitt Cancer Center (2006) [Pubmed]
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