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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Rhipicephalus


High impact information on Rhipicephalus

  • A novel proteinaceous metallo-carboxypeptidase inhibitor, named tick carboxypeptidase inhibitor (TCI), was isolated from the ixodid tick Rhipicephalus bursa and N-terminally sequenced [4].
  • They use an example the transmission of an important livestock pathogen, T. parva, by Rhipicephalus appendiculatus [5].
  • Dermacentor nuttallii from Siberia, Rhipicephalus sanguineus from Crimea, and Rh. pumilio from the Astrakhan region were infected with Rickettsia sibirica (12%), R. conorii (8%), and the Astrakhan fever agent (3%), respectively [6].
  • The Rhipicephalus rickettsia grew well in monolayers of chicken embryo fibroblast, Vero, mouse L, and HeLa cells [7].
  • In 1990, 17 adult Rhipicephalus turanicus ticks were collected in the south of France. Two spotted fever group rickettsiae, Mtu1 and Mtu5, were isolated from the hemolymphs of two of these ticks by the centrifugation shell-vial technique by using HEL cells [8].

Anatomical context of Rhipicephalus


Associations of Rhipicephalus with chemical compounds

  • We have previously undertaken preliminary characterization of two Rhipicephalus appendiculutus serine protease inhibitors (RAS-1 and -2) as anti-tick vaccine candidates [11].
  • Cloning, expression and partial characterization of a Haemaphysalis longicornis and a Rhipicephalus appendiculatus glutathione S-transferase [12].
  • OBJECTIVE: To compare the efficacies of amitraz and fipronil for prevention of experimental and natural infestations of Rhipicephalus sanguineus [13].
  • Serial sections of glycol methacrylate-embedded and frozen midguts of Boophilus microplus and Rhipicephalus appendiculatus were studied histochemically by light microscopy [14].
  • Resistance to the hard tick, Rhipicephalus appendiculatus, was induced in rabbits by immunizing them with tick tissue proteins extracted with a detergent, Triton X-100 [15].

Gene context of Rhipicephalus

  • In this study we found that Rhipicephalus sanguineus tick saliva stimulates transforming growth factor-beta (TGF-beta), and reduces interleukin-12 (IL-12) secretion by cells from normal C3H/HeJ mice [16].
  • We describe the isolation and characterisation of two putatively new acetylcholinesterase genes from the African cattle ticks Boophilus decoloratus and Rhipicephalus appendiculatus [17].
  • Sera of I. ricinus-infested rabbits and mice or of rabbits infested with Rhipicephalus appendiculatus adults reacted with a 20-kDa antigen in total extracts of partially fed R. appendiculatus females and the integument of this species [18].
  • The larvae obtained from engorged females of the one-host tick Boophilus decoloratus, the two-host tick Rhipicepalus evertsi evertsi and the three-host ticks Amblyomma hebraeum and Rhipicephalus appendiculatus were tested against various concentrations of amitraz, chlorfenvinphos and cypermethrin using the Shaw Larval Immersion Test method [19].
  • Although only small numbers were recovered, adult Haemaphysalis aciculifer were present from September to February, nymphs of Rhipicephalus appendiculatus from May to September, and adult Rhipicephalus lunulatus from December to March [20].

Analytical, diagnostic and therapeutic context of Rhipicephalus


  1. Viral interference in the tick, Rhipicephalus appendiculatus. II. Absence of interference with Thogoto virus when the tick gut is by-passed by parenteral inoculation. Jones, L.D., Davies, C.R., Booth, T.F., Nuttall, P.A. J. Gen. Virol. (1989) [Pubmed]
  2. Detection of Astrakhan fever rickettsia from ticks in Kosovo. Fournier, P.E., Durand, J.P., Rolain, J.M., Camicas, J.L., Tolou, H., Raoult, D. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  3. Theileria parva piroplasmosis in mice, and its attempted transmission with Rhipicephalus appendiculatus ticks. Irvin, A.D., Kanhai, G.K., Payne, R.C., Omwoyo, P.L. Tropenmedizin und Parasitologie. (1977) [Pubmed]
  4. A carboxypeptidase inhibitor from the tick Rhipicephalus bursa: isolation, cDNA cloning, recombinant expression, and characterization. Arolas, J.L., Lorenzo, J., Rovira, A., Castellà, J., Aviles, F.X., Sommerhoff, C.P. J. Biol. Chem. (2005) [Pubmed]
  5. Artificial feeding of ixodid ticks. Waladde, S.M., Young, A.S., Morzaria, S.P. Parasitol. Today (Regul. Ed.) (1996) [Pubmed]
  6. New Rickettsiae in ticks collected in territories of the former soviet union. Rydkina, E., Roux, V., Rudakov, N., Gafarova, M., Tarasevich, I., Raoult, D. Emerging Infect. Dis. (1999) [Pubmed]
  7. Rhipicephalus sanguineus: vector of a new spotted fever group rickettsia in the United States. Burgdorfer, W., Sexton, D.J., Gerloff, R.K., Anacker, R.L., Philip, R.N., Thomas, L.A. Infect. Immun. (1975) [Pubmed]
  8. Comparison of serologic typing, sodium dodecyl sulfate-polyacrylamide gel electrophoresis protein analysis, and genetic restriction fragment length polymorphism analysis for identification of rickettsiae: characterization of two new rickettsial strains. Beati, L., Finidori, J.P., Gilot, B., Raoult, D. J. Clin. Microbiol. (1992) [Pubmed]
  9. Salivary gland extract of Rhipicephalus appendiculatus ticks inhibits in vitro transcription and secretion of cytokines and production of nitric oxide by LPS-stimulated JA-4 cells. Gwakisa, P., Yoshihara, K., Long To, T., Gotoh, H., Amano, F., Momotani, E. Vet. Parasitol. (2001) [Pubmed]
  10. Effect of medium supplements on tick cells in culture. Kurtti, T.J., Munderloh, U.G., Samish, M. J. Parasitol. (1982) [Pubmed]
  11. Two serine protease inhibitors (serpins) that induce a bovine protective immune response against Rhipicephalus appendiculatus ticks. Imamura, S., Namangala, B., Tajima, T., Tembo, M.E., Yasuda, J., Ohashi, K., Onuma, M. Vaccine (2006) [Pubmed]
  12. Cloning, expression and partial characterization of a Haemaphysalis longicornis and a Rhipicephalus appendiculatus glutathione S-transferase. da Silva Vaz Jnr, I., Imamura, S., Ohashi, K., Onuma, M. Insect Mol. Biol. (2004) [Pubmed]
  13. Comparison of an amitraz-impregnated collar with topical administration of fipronil for prevention of experimental and natural infestations by the brown dog tick (Rhipicephalus sanguineus). Estrada-Peña, A., Ascher, F. J. Am. Vet. Med. Assoc. (1999) [Pubmed]
  14. Histochemical localisation of acid phosphatase and non-specific esterase in the midguts of two species of tick, Boophilus microplus and Rhipicephalus appendiculatus, as determined by light microscopy. Agyei, A.D., Herbert, I.V., Runham, N.W. Parasitol. Res. (1991) [Pubmed]
  15. Induction of host resistance to Rhipicephalus appendiculatus in rabbits: effects of immunizing with detergent-solubilized tick tissue proteins. Dhadialla, T.S., Rutti, B., Brossard, M. Parasitol. Res. (1990) [Pubmed]
  16. Successive tick infestations selectively promote a T-helper 2 cytokine profile in mice. Ferreira, B.R., Silva, J.S. Immunology (1999) [Pubmed]
  17. Comparison of acetylcholinesterase genes from cattle ticks. Baxter, G.D., Barker, S.C. Int. J. Parasitol. (1999) [Pubmed]
  18. Repetitive detection by immunoblotting of an integumental 25-kDa antigen in Ixodes ricinus and a corresponding 20-kDa antigen in Rhipicephalus appendiculatus with sera of pluriinfested mice and rabbits. Rutti, B., Brossard, M. Parasitol. Res. (1989) [Pubmed]
  19. Acaricide resistance profiles of single- and multi-host ticks from communal and commercial farming areas in the Eastern Cape and North-West Provinces of South Africa. Mekonnen, S., Bryson, N.R., Fourie, L.J., Peter, R.J., Spickett, A.M., Taylor, R.J., Strydom, T., Horak, I.G. Onderstepoort J. Vet. Res. (2002) [Pubmed]
  20. Parasites of domestic and wild animals in South Africa. XXIV. Arthropod parasites of bushbuck and common duiker in the Weza State Forest, Natal. Horak, I.G., Keep, M.E., Spickett, A.M., Boomker, J. Onderstepoort J. Vet. Res. (1989) [Pubmed]
  21. Investigations into the function and chemical compositions of the porose areas secretion of Rhipicephalus evertsi evertsi during oviposition. Vermeulen, N.M., Gothe, R., Senekal, A.C., Neitz, A.W. Onderstepoort J. Vet. Res. (1986) [Pubmed]
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