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Gene Review

PTS-P1  -  6-pyruvoyltetrahydropterin synthase...

Homo sapiens

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Disease relevance of PTS-P1

  • CONCLUSION: PTRA, PTSP, and RABG were equally efficacious for control of renovascular hypertension [1].
  • MATERIALS AND METHODS: Medical records and angiograms of 130 patients who underwent PTRA, PTSP, or RABG were retrospectively studied to determine success and complication rates, angiographic stenoses, blood pressures, antihypertensive medications, and serum creatinine levels [1].

High impact information on PTS-P1


Biological context of PTS-P1

  • We used the previously isolated PTPS cDNA as a probe and identified the human gene, PTS, located on chromosome 11q22.3-q23.3, and a retropseudogene, PTS-P1, assigned to 9p12-p13 (symbols approved by the human genome nomenclature committee) [2].

Analytical, diagnostic and therapeutic context of PTS-P1

  • PURPOSE: To compare the outcomes and costs of percutaneous transluminal renal angioplasty (PTRA), percutaneous transluminal stent placement (PTSP) of renal arteries, and renal arterial bypass grafting (RABG) in treatment of renovascular hypertension [1].
  • The difference in the total effective rate between the two groups was not statistically significant (P > 0.05), suggesting that electroacupuncture at Huatuojiaji (Extra) is a better therapy for PTSP [3].
  • The authors have treated 30 cases of postapoplectic thalamic spontaneous pain (PTSP) by electro-acupuncture at Huatuojiaji points (Extra), with the other 30 cases of PTSP treated by oral administration of carbamazepine as the controls [3].


  1. Outcome and cost comparison of percutaneous transluminal renal angioplasty, renal arterial stent placement, and renal arterial bypass grafting. Xue, F., Bettmann, M.A., Langdon, D.R., Wivell, W.A. Radiology. (1999) [Pubmed]
  2. Chromosomal localization, genomic structure and characterization of the human gene and a retropseudogene for 6-pyruvoyltetrahydropterin synthase. Kluge, C., Brecevic, L., Heizmann, C.W., Blau, N., Thöny, B. Eur. J. Biochem. (1996) [Pubmed]
  3. Treatment of postapoplectic thalamic spontaneous pain by electroacupuncture at huatuojiaji points. Jiang, Z., Li, C., Li, Y. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine. (1999) [Pubmed]
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