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Gene Review

CCNL1  -  cyclin L1

Homo sapiens

Synonyms: ANIA6A, BM-001, Cyclin-L, Cyclin-L1, PRO1073, ...
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Disease relevance of CCNL1


High impact information on CCNL1

  • Human cyclin L2 shares significant homology to cyclin L1, K, T1, T2, and C, which are involved in transcriptional regulation via phosphorylation of the C-terminal domain of RNA polymerase II [4].
  • We report the cDNA cloning and functional characterization of human cyclin L, a novel cyclin related to the C-type cyclins that are involved in regulation of RNA polymerase II (pol II) transcription [5].
  • Significantly, the IC(50) for splicing inhibition by p21 is similar to the IC(50) for inhibition of the cyclin L-associated kinase activity [5].
  • Cyclin L antibody inhibits the second step of RNA splicing in vitro, and recombinant cyclin L protein stimulates splicing under suboptimal conditions [5].
  • Cyclin L is an RS domain protein involved in pre-mRNA splicing [5].

Biological context of CCNL1

  • We evaluated the expression and amplification of cyclin L1 (CCNL1) gene, a potential oncogene localised in the commonly amplified 3q25-28 region, in human head and neck squamous cell carcinomas (HNSCCs) [1].
  • Recently, we reported that CDK12 interacts with L-type cyclins and is involved in alternative splicing regulation [H.-H. Chen, Y.-C. Wang, M.-J. Fann, Identification and characterization of the CDK12/Cyclin L1 complex involved in alternative splicing regulation, Mol. Cel. Biol. 26 (2006) 2736-2745] [6].


  1. Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma. Muller, D., Millon, R., Théobald, S., Hussenet, T., Wasylyk, B., du Manoir, S., Abecassis, J. Br. J. Cancer (2006) [Pubmed]
  2. Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC). Sticht, C., Hofele, C., Flechtenmacher, C., Bosch, F.X., Freier, K., Lichter, P., Joos, S. Br. J. Cancer (2005) [Pubmed]
  3. Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer. Redon, R., Hussenet, T., Bour, G., Caulee, K., Jost, B., Muller, D., Abecassis, J., du Manoir, S. Cancer Res. (2002) [Pubmed]
  4. Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells. Yang, L., Li, N., Wang, C., Yu, Y., Yuan, L., Zhang, M., Cao, X. J. Biol. Chem. (2004) [Pubmed]
  5. Cyclin L is an RS domain protein involved in pre-mRNA splicing. Dickinson, L.A., Edgar, A.J., Ehley, J., Gottesfeld, J.M. J. Biol. Chem. (2002) [Pubmed]
  6. CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing. Chen, H.H., Wong, Y.H., Geneviere, A.M., Fann, M.J. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
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