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Disease relevance of Parathyroidectomy


Psychiatry related information on Parathyroidectomy


High impact information on Parathyroidectomy

  • Patients with secondary hyperparathyroidism who may be candidates for parathyroidectomy should be evaluated for aluminum excess before surgery, so that treatment with aluminum chelation may be considered [7].
  • This hypothesis was supported by the findings that the attenuated PTH-sensitive Na+/Ca2+ exchange activity, cAMP formation, and adenylate cyclase activity in cells from old rats could be reversed by parathyroidectomy [8].
  • After parathyroidectomy, sBGP slowly returned to normal values within 2-6 mo, suggesting that sBGP reflects increased bone turnover rather than a direct effect of parathyroid hormone on BGP synthesis at the cell level [9].
  • To disclose a parathyroid-independent calcium modulation of phosphate transport along the nephron, the effect of increasing plasma calcium concentration to subnormal levels in rats 6 days after parathyroidectomy (chronic PTX) was studied [10].
  • Parathyroidectomy per se increased apical membrane NHE-3 activity and antigen [11].

Chemical compound and disease context of Parathyroidectomy


Biological context of Parathyroidectomy


Anatomical context of Parathyroidectomy


Associations of Parathyroidectomy with chemical compounds


Gene context of Parathyroidectomy


Analytical, diagnostic and therapeutic context of Parathyroidectomy


  1. Hypercalcaemic osteomalacia due to aluminium toxicity. Boyce, B.F., Fell, G.S., Elder, H.Y., Junor, B.J., Elliot, H.L., Beastall, G., Fogelman, I., Boyle, I.T. Lancet (1982) [Pubmed]
  2. Gastrin releases a blood calcium-lowering peptide from the acid-producing part of the rat stomach. Persson, P., Håkanson, R., Axelson, J., Sundler, F. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  3. Results of parathyroidectomy for autonomous hyperparathyroidism. Swanson, M.R., Biggers, J.A., Remmers, A.R., Sarles, H.E., Nelson, R.M., Fish, J.C. Arch. Intern. Med. (1979) [Pubmed]
  4. Acute myelofibrosis and malignant hypercalcemia. Libnoch, J.A., Ajlouni, K., Millman, W.L., Guansing, A.R., Theil, G.B. Am. J. Med. (1977) [Pubmed]
  5. Radioguided parathyroidectomy for recurrent hyperparathyroidism caused by forearm graft hyperplasia. Sippel, R.S., Bianco, J., Chen, H. J. Bone Miner. Res. (2003) [Pubmed]
  6. Surgery in primary hyperparathyroidism: the patient without previous neck surgery. Udelsman, R. J. Bone Miner. Res. (2002) [Pubmed]
  7. Effect of parathyroidectomy on bone aluminum accumulation in chronic renal failure. Andress, D.L., Ott, S.M., Maloney, N.A., Sherrard, D.J. N. Engl. J. Med. (1985) [Pubmed]
  8. Desensitization to parathyroid hormone in renal cells from aged rats is associated with alterations in G-protein activity. Hanai, H., Liang, C.T., Cheng, L., Sacktor, B. J. Clin. Invest. (1989) [Pubmed]
  9. Serum bone gamma carboxyglutamic acid-containing protein in primary hyperparathyroidism and in malignant hypercalcemia. Comparison with bone histomorphometry. Delmas, P.D., Demiaux, B., Malaval, L., Chapuy, M.C., Edouard, C., Meunier, P.J. J. Clin. Invest. (1986) [Pubmed]
  10. Evidence for a parathyroid hormone-independent calcium modulation of phosphate transport along the nephron. Amiel, C., Kuntziger, H., Couette, S., Coureau, C., Bergounioux, N. J. Clin. Invest. (1976) [Pubmed]
  11. Dual mechanisms of regulation of Na/H exchanger NHE-3 by parathyroid hormone in rat kidney. Fan, L., Wiederkehr, M.R., Collazo, R., Wang, H., Crowder, L.A., Moe, O.W. J. Biol. Chem. (1999) [Pubmed]
  12. Hyperparathyroidism and anemia in uremic subjects: a combined therapeutic approach. Brancaccio, D., Cozzolino, M., Gallieni, M. J. Am. Soc. Nephrol. (2004) [Pubmed]
  13. The influence of hyperparathyroidism on glucose metabolism in uremia. Mak, R.H., Bettinelli, A., Turner, C., Haycock, G.B., Chantler, C. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  14. Derangements in acetylcholine metabolism in brain synaptosomes in chronic renal failure. Ni, Z., Smogorzewski, M., Massry, S.G. Kidney Int. (1993) [Pubmed]
  15. Localization of parathyroid glands using technetium-99m-tetrofosmin imaging. Ishibashi, M., Nishida, H., Strauss, H.W., Kojima, K., Fujito, H., Watanabe, J., Hiromatsu, Y., Hayabuchi, N. J. Nucl. Med. (1997) [Pubmed]
  16. Evidence for a role of PTH in the reduced pressor response to norepinephrine in chronic renal failure. Iseki, K., Massry, S.G., Campese, V.M. Kidney Int. (1985) [Pubmed]
  17. Increased bone mineral density after parathyroidectomy in primary hyperparathyroidism. Silverberg, S.J., Gartenberg, F., Jacobs, T.P., Shane, E., Siris, E., Staron, R.B., McMahon, D.J., Bilezikian, J.P. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  18. Therapy of diseased stroke-prone spontaneously hypertensive rats with nimodipine. Lenz, P., Luckhaus, G., Stasch, J.P., Kazda, S. Stroke (1990) [Pubmed]
  19. Metabolic effects of parathyroidectomy in asymptomatic primary hyperparathyroidism. Kaplan, R.A., Snyder, W.H., Stewart, A., Pak, C.Y. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  20. Impaired flow-mediated vasodilation of the brachial artery in patients with primary hyperparathyroidism improves after parathyroidectomy. Kosch, M., Hausberg, M., Vormbrock, K., Kisters, K., Gabriels, G., Rahn, K.H., Barenbrock, M. Cardiovasc. Res. (2000) [Pubmed]
  21. Radioguided parathyroidectomy is equally effective for both adenomatous and hyperplastic glands. Chen, H., Mack, E., Starling, J.R. Ann. Surg. (2003) [Pubmed]
  22. The NIH criteria for parathyroidectomy in asymptomatic primary hyperparathyroidism: are they too limited? Eigelberger, M.S., Cheah, W.K., Ituarte, P.H., Streja, L., Duh, Q.Y., Clark, O.H. Ann. Surg. (2004) [Pubmed]
  23. Insulin release from pancreatic islets: effects of CRF and excess PTH. Fadda, G.Z., Akmal, M., Premdas, F.H., Lipson, L.G., Massry, S.G. Kidney Int. (1988) [Pubmed]
  24. Down-regulation of PTH-PTHrP receptor of heart in CRF: role of [Ca2+]i. Smogorzewski, M., Tian, J., Massry, S.G. Kidney Int. (1995) [Pubmed]
  25. Parathyroidectomy ameliorates vascular lesions induced by deoxycorticosterone in the rat. Nickerson, P.A., Conran, R.M. Am. J. Pathol. (1981) [Pubmed]
  26. Effects of thyroparathyroidectomy, exogenous calcium, and short-term calcitriol therapy on the growth plate in renal failure. Sanchez, C.P., He, Y.Z. J. Am. Soc. Nephrol. (2003) [Pubmed]
  27. Reduced activity of Na(+)-K+ ATPase of pancreatic islets in chronic renal failure: role of secondary hyperparathyroidism. Hajjar, S.M., Fadda, G.Z., Thanakitcharu, P., Smogorzewski, M., Massry, S.G. J. Am. Soc. Nephrol. (1992) [Pubmed]
  28. Humoral hypercalcemia in Hodgkin's disease. Association with elevated 1,25-dihydroxycholecalciferol levels and subperiosteal bone resorption. Zaloga, G.P., Eil, C., Medbery, C.A. Arch. Intern. Med. (1985) [Pubmed]
  29. Intraoperative urinary cyclic adenosine monophosphate as a guide to successful reoperative parathyroidectomy. Norton, J.A., Brennan, M.F., Saxe, A.W., Wesley, R.A., Doppman, J.L., Krudy, A.G., Marx, S.J., Santora, A.C., Hicks, M., Aurbach, G.D. Ann. Surg. (1984) [Pubmed]
  30. IL-1beta, TNF-alpha, TGF-beta, and bFGF expression in bone biopsies before and after parathyroidectomy. Santos, F.R., Moysés, R.M., Montenegro, F.L., Jorgetti, V., Noronha, I.L. Kidney Int. (2003) [Pubmed]
  31. Skeletal changes in osteoprotegerin and receptor activator of nuclear factor-kappab ligand mRNA levels in primary hyperparathyroidism: effect of parathyroidectomy and association with bone metabolism. Stilgren, L.S., Rettmer, E., Eriksen, E.F., Hegedüs, L., Beck-Nielsen, H., Abrahamsen, B. Bone (2004) [Pubmed]
  32. Parathyroid surgery in familial hyperparathyroid disorders. Carling, T., Udelsman, R. J. Intern. Med. (2005) [Pubmed]
  33. Fibroblast growth factor (FGF)-23 in patients with primary hyperparathyroidism. Yamashita, H., Yamashita, T., Miyamoto, M., Shigematsu, T., Kazama, J.J., Shimada, T., Yamazaki, Y., Fukumoto, S., Fukagaw, M., Noguchi, S. Eur. J. Endocrinol. (2004) [Pubmed]
  34. The fall and rise of parathyroidectomy in U.S. hemodialysis patients, 1992 to 2002. Foley, R.N., Li, S., Liu, J., Gilbertson, D.T., Chen, S.C., Collins, A.J. J. Am. Soc. Nephrol. (2005) [Pubmed]
  35. Total parathyroidectomy with forearm autograft for secondary hyperparathyroidism in chronic renal failure. Takagi, H., Tominaga, Y., Tanaka, Y., Uchida, K., Orihara, A., Yamada, N., Kawai, M., Hayashi, S., Taira, N., Kano, T. Ann. Surg. (1988) [Pubmed]
  36. Image diagnosis of parathyroid glands in chronic renal failure. Takagi, H., Tominaga, Y., Uchida, K., Yamada, N., Morimoto, T., Yasue, M. Ann. Surg. (1983) [Pubmed]
  37. Severe hyperparathyroidism associated with prolonged hungry bone syndrome in a renal transplant recipient. Miles, A.M., Markell, M.S., Sumrani, N., Hong, J., Friedman, E.A. J. Am. Soc. Nephrol. (1997) [Pubmed]
  38. Hypertension and hyperparathyroidism. Inverse relation of serum phosphate level and blood pressure. Daniels, J., Goodman, A.D. Am. J. Med. (1983) [Pubmed]
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