Disease relevance of CLLU1

• However, appreciable levels of CLLU1 were detectable only in CLL cells and not in a panel of normal tissue extracts or in any other tested hematologic malignancy [1].
• CLLU1 expression levels predict time to initiation of therapy and overall survival in chronic lymphocytic leukemia [2].
• The relation between CLLU1 expression and time to therapy, overall survival and presence or absence of ZAP-70, CD38, chromosomal aberrations or IgV(H) mutations in the 59 patients was analyzed [2].

High impact information on CLLU1

• CLLU1 encodes 6 mRNAs with no sequence homology to any known gene, and most transcripts appear to be noncoding [1].
• High expression of CLLU1 in CLL samples occurred irrespective of trisomy 12 or large chromosomal rearrangements [1].
• CLLU1 mapped to chromosome 12q22, within a cluster of genes that are active in germinal center B cells [1].
• Using differential display to compare gene expression in CLL cells with and without IgVH hypermutations, we identified a novel gene, CLL up-regulated gene 1 (CLLU1), that was highly up-regulated in CLL cells without IgVH hypermutations [1].
• Patient stratification according to clinical stage, cytogenetics, IgV(H) mutational status, ZAP-70 and CD38, demonstrated significantly increased CLLU1 expression in all investigated CLL poor risk groups [2].

Analytical, diagnostic and therapeutic context of CLLU1

• We determined the expression levels of two CLLU1 transcripts, cDNA1 and CDS, by quantitative RT-PCR [2].

References