Gene Review:
ZAP70 - zeta-chain (TCR) associated protein kinase...
Homo sapiens
Synonyms:
70 kDa zeta-chain associated protein, SRK, STCD, STD, Syk-related tyrosine kinase, ...
Gattei,
Jin,
Morris,
Del Principe,
Chen,
Capelli,
Schraven,
Morrison,
Loria,
Mazzone,
Bruyns,
Kirchgessner,
Prada,
Yu,
Cantonetti,
Burakoff,
Burrows,
Cantrell,
Meuer,
Marie-Cardine,
Buccisano,
Kipps,
Lo Coco,
Patankar,
Venditti,
Amadori,
Wong,
Consalvo,
Clark,
Del Poeta,
Lattanzio,
Deng,
Castro,
Belisle,
Bruno,
Eckerskorn,
Gianní,
Kamal,
Dell,
Jing,
Maurillo,
- Defective expression of the T-cell receptor-CD3 zeta chain in T-cell acute lymphoblastic leukaemia. Torelli, G.F., Paolini, R., Tatarelli, C., Soriani, A., Vitale, A., Guarini, A., Santoni, A., Foa, R. Br. J. Haematol. (2003)
- Distribution and ZAP-70 expression of WHO lymphoma categories in Shanxi, China: a review of 447 cases using a tissue microarray technique. Wang, J., Young, L., Win, W., Taylor, C.R. Appl. Immunohistochem. Mol. Morphol. (2005)
- ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Chen, L., Apgar, J., Huynh, L., Dicker, F., Giago-McGahan, T., Rassenti, L., Weiss, A., Kipps, T.J. Blood (2005)
- ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells. Gobessi, S., Laurenti, L., Longo, P.G., Sica, S., Leone, G., Efremov, D.G. Blood (2007)
- The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Chan, A.C., Desai, D.M., Weiss, A. Annu. Rev. Immunol. (1994)
- LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Zhang, W., Sloan-Lancaster, J., Kitchen, J., Trible, R.P., Samelson, L.E. Cell (1998)
- ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Chan, A.C., Iwashima, M., Turck, C.W., Weiss, A. Cell (1992)
- ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia. Castro, J.E., Prada, C.E., Loria, O., Kamal, A., Chen, L., Burrows, F.J., Kipps, T.J. Blood (2005)
- Correlation of ZAP-70 expression in B cell leukemias to the ex vivo response to a combination of fludarabine/genistein. Mansour, A., Chang, V.T., Srinivas, S., Harrison, J., Raveche, E. Cancer Immunol. Immunother. (2007)
- The addition of rituximab to fludarabine improves clinical outcome in untreated patients with ZAP-70-negative chronic lymphocytic leukemia. Del Poeta, G., Del Principe, M.I., Consalvo, M.A., Maurillo, L., Buccisano, F., Venditti, A., Mazzone, C., Bruno, A., Gianní, L., Capelli, G., Lo Coco, F., Cantonetti, M., Gattei, V., Amadori, S. Cancer (2005)
- Trichostatin A down-regulates ZAP-70, LAT and SLP-76 content in Jurkat T cells. Januchowski, R., Jagodzinski, P.P. Int. Immunopharmacol. (2007)
- Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists. Lühder, F., Huang, Y., Dennehy, K.M., Guntermann, C., Müller, I., Winkler, E., Kerkau, T., Ikemizu, S., Davis, S.J., Hanke, T., Hünig, T. J. Exp. Med. (2003)
- Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Seggewiss, R., Loré, K., Greiner, E., Magnusson, M.K., Price, D.A., Douek, D.C., Dunbar, C.E., Wiestner, A. Blood (2005)
- Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes. Marie-Cardine, A., Bruyns, E., Eckerskorn, C., Kirchgessner, H., Meuer, S.C., Schraven, B. J. Biol. Chem. (1997)
- MHC class I ligation of human T cells activates the ZAP70 and p56lck tyrosine kinases, leads to an alternative phenotype of the TCR/CD3 zeta-chain, and induces apoptosis. Skov, S., Bregenholt, S., Claesson, M.H. J. Immunol. (1997)
- Identification of a novel dimeric phosphoprotein (PP29/30) associated with signaling receptors in human T lymphocytes and natural killer cells. Schraven, B., Ratnofsky, S., Gaumont, Y., Lindegger, H., Kirchgessner, H., Bruyns, E., Moebius, U., Meuer, S.C. J. Exp. Med. (1994)
- T cell receptor (TCR) engagement in apoptosis-defective, but interleukin 2 (IL-2)-producing, T cells results in impaired ZAP70/CD3-zeta association. Sahuquillo, A.G., Roumier, A., Teixeiro, E., Bragado, R., Alarcón, B. J. Exp. Med. (1998)
- Defective TCR stimulation in anergized type 2 T helper cells correlates with abrogated p56(lck) and ZAP-70 tyrosine kinase activities. Faith, A., Akdis, C.A., Akdis, M., Simon, H.U., Blaser, K. J. Immunol. (1997)
- Potent suppression of natural killer cell response mediated by the ovarian tumor marker CA125. Patankar, M.S., Jing, Y., Morrison, J.C., Belisle, J.A., Lattanzio, F.A., Deng, Y., Wong, N.K., Morris, H.R., Dell, A., Clark, G.F. Gynecol. Oncol. (2005)
- In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern. Blanchard, N., Di Bartolo, V., Hivroz, C. Immunity (2002)
- The real LAT steps forward. Cantrell, D. Trends Cell Biol. (1998)
- Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activity. Jin, Y.J., Yu, C.L., Burakoff, S.J. J. Biol. Chem. (1999)
- Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling. Di Bartolo, V., Mège, D., Germain, V., Pelosi, M., Dufour, E., Michel, F., Magistrelli, G., Isacchi, A., Acuto, O. J. Biol. Chem. (1999)
- Structural basis for the inhibition of tyrosine kinase activity of ZAP-70. Deindl, S., Kadlecek, T.A., Brdicka, T., Cao, X., Weiss, A., Kuriyan, J. Cell (2007)
- The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling. Han, J., Kori, R., Shui, J.W., Chen, Y.R., Yao, Z., Tan, T.H. J. Biol. Chem. (2003)
- Interaction of human MUC1 and beta-catenin is regulated by Lck and ZAP-70 in activated Jurkat T cells. Li, Q., Ren, J., Kufe, D. Biochem. Biophys. Res. Commun. (2004)
- Tyrosine phosphorylation and recruitment of ZAP-70 to the CD3-TCR complex are defective after CD2 stimulation. Hubert, P., Lang, V., Debré, P., Bismuth, G. J. Immunol. (1996)
- Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation. Pacini, S., Ulivieri, C., Di Somma, M.M., Isacchi, A., Lanfrancone, L., Pelicci, P.G., Telford, J.L., Baldari, C.T. J. Biol. Chem. (1998)
- Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. Wardenburg, J.B., Fu, C., Jackman, J.K., Flotow, H., Wilkinson, S.E., Williams, D.H., Johnson, R., Kong, G., Chan, A.C., Findell, P.R. J. Biol. Chem. (1996)
- A dual participation of ZAP-70 and scr protein tyrosine kinases is required for TCR-induced tyrosine phosphorylation of Sam68 in Jurkat T cells. Lang, V., Mège, D., Semichon, M., Gary-Gouy, H., Bismuth, G. Eur. J. Immunol. (1997)
- Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. Chan, A.C., Dalton, M., Johnson, R., Kong, G.H., Wang, T., Thoma, R., Kurosaki, T. EMBO J. (1995)
- Distinct role of ZAP-70 and Src homology 2 domain-containing leukocyte protein of 76 kDa in the prolonged activation of extracellular signal-regulated protein kinase by the stromal cell-derived factor-1 alpha/CXCL12 chemokine. Kremer, K.N., Humphreys, T.D., Kumar, A., Qian, N.X., Hedin, K.E. J. Immunol. (2003)
- TNF activates Syk protein tyrosine kinase leading to TNF-induced MAPK activation, NF-kappaB activation, and apoptosis. Takada, Y., Aggarwal, B.B. J. Immunol. (2004)
- CD44 signaling through p56lck involves lateral association with CD4 in human CD4+ T cells. Dianzani, U., Bragardo, M., Tosti, A., Ruggeri, L., Volpi, I., Casucci, M., Bottarel, F., Feito, M.J., Bonissoni, S., Velardi, A. Int. Immunol. (1999)
- Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Plas, D.R., Johnson, R., Pingel, J.T., Matthews, R.J., Dalton, M., Roy, G., Chan, A.C., Thomas, M.L. Science (1996)
- SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling. Tang, J., Sawasdikosol, S., Chang, J.H., Burakoff, S.J. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Chen, L., Widhopf, G., Huynh, L., Rassenti, L., Rai, K.R., Weiss, A., Kipps, T.J. Blood (2002)
- Signaling through ZAP-70 is required for CXCL12-mediated T-cell transendothelial migration. Ticchioni, M., Charvet, C., Noraz, N., Lamy, L., Steinberg, M., Bernard, A., Deckert, M. Blood (2002)
- The hetero-oligomeric antigen receptor complex and its coupling to cytoplasmic effectors. Cambier, J.C., Jensen, W.A. Curr. Opin. Genet. Dev. (1994)
- Combined analysis of ZAP-70 and CD38 expression as a predictor of disease progression in B-cell chronic lymphocytic leukemia. Schroers, R., Griesinger, F., Trümper, L., Haase, D., Kulle, B., Klein-Hitpass, L., Sellmann, L., Dührsen, U., Dürig, J. Leukemia (2005)
- Association of a 70-kDa tyrosine phosphoprotein with the CD16: zeta: gamma complex expressed in human natural killer cells. Vivier, E., da Silva, A.J., Ackerly, M., Levine, H., Rudd, C.E., Anderson, P. Eur. J. Immunol. (1993)
- SPAP2, an Ig family receptor containing both ITIMs and ITAMs. Xu, M.J., Zhao, R., Cao, H., Zhao, Z.J. Biochem. Biophys. Res. Commun. (2002)