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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ABCB1  -  ATP-binding cassette, sub-family B...

Macaca mulatta

 
 
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High impact information on MDR1

  • After 3 cycles of stem cell factor/granulocyte colony-stimulating factor, there were no changes in the levels of MDR1 vector- or neo vector-containing cells [1].
  • From 6 weeks to 10 months after the transplant, all animals contained MDR1 DNA in spleen and bone marrow specimens as indicated by Southern-blot analysis and expressed MDR1 RNA in bone marrow samples as detected by slot-blot analysis [2].
 

Anatomical context of MDR1

  • In our first set of experiments, we transplanted bone marrow cells derived from transgenic mice that constitutively express MDR1 to lethally irradiated recipients (n = 36) [2].
 

Analytical, diagnostic and therapeutic context of MDR1

  • Upon transplantation, high-level and long-lasting expression of the human MDR1 gene was observed in recipient monkeys.(ABSTRACT TRUNCATED AT 250 WORDS)[2]

References

  1. The effect of multidrug-resistance 1 gene versus neo transduction on ex vivo and in vivo expansion of rhesus macaque hematopoietic repopulating cells. Sellers, S.E., Tisdale, J.F., Agricola, B.A., Metzger, M.E., Donahue, R.E., Dunbar, C.E., Sorrentino, B.P. Blood (2001) [Pubmed]
  2. From laboratory expertise to clinical practice: multidrug-resistance-based gene therapy becomes available for urologists. Mickisch, G.H., Schroeder, F.H. World journal of urology. (1994) [Pubmed]
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