Gene Review:
Abcb1a - ATP-binding cassette, sub-family B...
Mus musculus
Synonyms:
ATP-binding cassette sub-family B member 1A, Abcb4, Evi32, MDR1A, MDR3, ...
- Functional modulation of multidrug resistance-related P-glycoprotein by Ca(2+)-calmodulin. Schlemmer, S.R., Yang, C.H., Sirotnak, F.M. J. Biol. Chem. (1995)
- A role for P-glycoprotein in environmental toxicology. Abu-Qare, A.W., Elmasry, E., Abou-Donia, M.B. Journal of toxicology and environmental health. Part B, Critical reviews. (2003)
- Dipyridamole modulates multidrug resistance and intracellular as well as nuclear levels of doxorubicin in B16 melanoma cells. Damle, B.D., Sridhar, R., Desai, P.B. Int. J. Cancer (1994)
- Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport. Hrycyna, C.A., Airan, L.E., Germann, U.A., Ambudkar, S.V., Pastan, I., Gottesman, M.M. Biochemistry (1998)
- P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. Cirrito, J.R., Deane, R., Fagan, A.M., Spinner, M.L., Parsadanian, M., Finn, M.B., Jiang, H., Prior, J.L., Sagare, A., Bales, K.R., Paul, S.M., Zlokovic, B.V., Piwnica-Worms, D., Holtzman, D.M. J. Clin. Invest. (2005)
- The role of the polymorphic efflux transporter P-glycoprotein on the brain accumulation of d-methylphenidate and d-amphetamine. Zhu, H.J., Wang, J.S., DeVane, C.L., Williard, R.L., Donovan, J.L., Middaugh, L.D., Gibson, B.B., Patrick, K.S., Markowitz, J.S. Drug Metab. Dispos. (2006)
- Antinociceptive effects of morphine-6-glucuronide in homozygous MDR1a P-glycoprotein knockout and in wildtype mice in the hotplate test. Lötsch, J., Tegeder, I., Angst, M.S., Geisslinger, G. Life Sci. (2000)
- Resistance mechanisms in murine tumors with acquired multidrug resistance. Volm, M., Efferth, T., Mattern, J., Pommerenke, E.W. Arzneimittel-Forschung. (1992)
- MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. van Helvoort, A., Smith, A.J., Sprong, H., Fritzsche, I., Schinkel, A.H., Borst, P., van Meer, G. Cell (1996)
- Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Schinkel, A.H., Smit, J.J., van Tellingen, O., Beijnen, J.H., Wagenaar, E., van Deemter, L., Mol, C.A., van der Valk, M.A., Robanus-Maandag, E.C., te Riele, H.P. Cell (1994)
- Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection. Morizono, K., Xie, Y., Ringpis, G.E., Johnson, M., Nassanian, H., Lee, B., Wu, L., Chen, I.S. Nat. Med. (2005)
- Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein. Valverde, M.A., Díaz, M., Sepúlveda, F.V., Gill, D.R., Hyde, S.C., Higgins, C.F. Nature (1992)
- Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies. Kartner, N., Evernden-Porelle, D., Bradley, G., Ling, V. Nature (1985)
- Effect of P-glycoprotein on the pharmacokinetics and tissue distribution of enaminone anticonvulsants: analysis by population and physiological approaches. Cox, D.S., Scott, K.R., Gao, H., Eddington, N.D. J. Pharmacol. Exp. Ther. (2002)
- Kinetics of daunorubicin transport in Ehrlich ascites tumor cells with different expression of P-glycoprotein. Nielsen, D., Maare, C., Skovsgaard, T. Biochem. Pharmacol. (1994)
- P-glycoprotein (MDR 1 gene product) in cells of the immune system: its possible physiologic role and alteration in aging and human immunodeficiency virus-1 (HIV-1) infection. Gupta, S., Gollapudi, S. J. Clin. Immunol. (1993)
- Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein. Sikic, B.I., Fisher, G.A., Lum, B.L., Halsey, J., Beketic-Oreskovic, L., Chen, G. Cancer Chemother. Pharmacol. (1997)
- Disruption of mdr1a p-glycoprotein gene results in dysfunction of blood-inner ear barrier in mice. Zhang, Z.J., Saito, T., Kimura, Y., Sugimoto, C., Ohtsubo, T., Saito, H. Brain Res. (2000)
- Mutational analysis of conserved aromatic residues in the A-loop of the ABC transporter ABCB1A (mouse Mdr3). Carrier, I., Urbatsch, I.L., Senior, A.E., Gros, P. FEBS Lett. (2007)
- Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood-brain barrier of Abcb1a gene knockout mice. Wang, J.S., Ruan, Y., Taylor, R.M., Donovan, J.L., Markowitz, J.S., DeVane, C.L. Psychopharmacology (Berl.) (2004)
- Multidrug resistance phosphoglycoprotein (ABCB1) in the mouse placenta: fetal protection. Kalabis, G.M., Kostaki, A., Andrews, M.H., Petropoulos, S., Gibb, W., Matthews, S.G. Biol. Reprod. (2005)
- Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): comparison of rat P-glycoprotein transport to human and mouse. Booth-Genthe, C.L., Louie, S.W., Carlini, E.J., Li, B., Leake, B.F., Eisenhandler, R., Hochman, J.H., Mei, Q., Kim, R.B., Rushmore, T.H., Yamazaki, M. Journal of pharmacological and toxicological methods. (2006)
- Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. Smit, J.W., Huisman, M.T., van Tellingen, O., Wiltshire, H.R., Schinkel, A.H. J. Clin. Invest. (1999)
- Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection. Choi, K., Frommel, T.O., Stern, R.K., Perez, C.F., Kriegler, M., Tsuruo, T., Roninson, I.B. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Functional expression of P-glycoprotein encoded by the mouse mdr3 gene in yeast cells. Ruetz, S., Raymond, M., Gros, P. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. Schinkel, A.H., Wagenaar, E., van Deemter, L., Mol, C.A., Borst, P. J. Clin. Invest. (1995)
- Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Mechetner, E.B., Roninson, I.B. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities. Devault, A., Gros, P. Mol. Cell. Biol. (1990)
- Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes. Mercier, C., Masseguin, C., Roux, F., Gabrion, J., Scherrmann, J.M. Brain Res. (2004)
- Mdr P-glycoproteins are not essential for biliary excretion of the hydrophobic heme precursor protoporphyrin in a griseofulvin-induced mouse model of erythropoietic protoporphyria. Plösch, T., Bloks, V.W., Baller, J.F., Havinga, R., Verkade, H.J., Jansen, P.L., Kuipers, F. Hepatology (2002)
- Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis. De Vree, J.M., Ottenhoff, R., Bosma, P.J., Smith, A.J., Aten, J., Oude Elferink, R.P. Gastroenterology (2000)
- Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells. Dohgu, S., Yamauchi, A., Takata, F., Naito, M., Tsuruo, T., Higuchi, S., Sawada, Y., Kataoka, Y. Cell. Mol. Neurobiol. (2004)
- Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice. Vlaming, M.L., Mohrmann, K., Wagenaar, E., de Waart, D.R., Elferink, R.P., Lagas, J.S., van Tellingen, O., Vainchtein, L.D., Rosing, H., Beijnen, J.H., Schellens, J.H., Schinkel, A.H. J. Pharmacol. Exp. Ther. (2006)
- Murine mdr-1, mdr-2, and mdr-3 gene expression: no coinduction with the Cyp1a-1 and Nmo-1 genes in liver by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Teeter, L.D., Petersen, D.D., Nebert, D.W., Kuo, M.T. DNA Cell Biol. (1991)
- Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice. van Asperen, J., Schinkel, A.H., Beijnen, J.H., Nooijen, W.J., Borst, P., van Tellingen, O. J. Natl. Cancer Inst. (1996)
- Cytokine-based tumor cell vaccine is equally effective against parental and isogenic multidrug-resistant myeloma cells: the role of cytotoxic T lymphocytes. Shtil, A.A., Turner, J.G., Durfee, J., Dalton, W.S., Yu, H. Blood (1999)