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Gene Review

HCN3  -  hyperpolarization activated cyclic...

Homo sapiens

Synonyms: KIAA1535, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
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High impact information on HCN3

  • Surprisingly, HEK-293 cells were found to contain mRNA for HCN2 and HCN3 although we have not detected a significant and consistent endogenous I(f)-like current in these cells [1].
  • 3. Like all other HCNs, hHCN3 was inhibited rapidly and reversibly by extracellular cesium and slowly and irreversibly by extracellular applied ZD7288 [2].
  • HCN3 currents revealed slow activation and deactivation kinetics and were effectively blocked by extracellular Cs+ and the bradycardic agent ivabradine [3].
  • Using reverse transcriptase PCR transcripts of HCN3 were also detected in heart ventricle [3].
  • An interactive tool for extracting exons and SNP from genomic sequence: isolation of HCN1 and HCN3 ion channel genes [4].

Other interactions of HCN3

  • Surprisingly, HCN2 and HCN3 did not coassemble to heteromeric channels [5].
  • The study described in this paper demonstrates the use of GenoA to study human brain hyperpolarization-activated cation channel genes HCN1 and HCN3 [4].

Analytical, diagnostic and therapeutic context of HCN3


  1. Endogenous channels in HEK cells and potential roles in HCN ionic current measurements. Varghese, A., Tenbroek, E.M., Coles, J., Sigg, D.C. Prog. Biophys. Mol. Biol. (2006) [Pubmed]
  2. Functional expression of the human HCN3 channel. Stieber, J., Stöckl, G., Herrmann, S., Hassfurth, B., Hofmann, F. J. Biol. Chem. (2005) [Pubmed]
  3. The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides. Mistrík, P., Mader, R., Michalakis, S., Weidinger, M., Pfeifer, A., Biel, M. J. Biol. Chem. (2005) [Pubmed]
  4. An interactive tool for extracting exons and SNP from genomic sequence: isolation of HCN1 and HCN3 ion channel genes. Liu, Y., Wang, Y., Folander, K., Xie, G., Blevins, R. Journal of bioinformatics and computational biology. (2003) [Pubmed]
  5. Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels. Much, B., Wahl-Schott, C., Zong, X., Schneider, A., Baumann, L., Moosmang, S., Ludwig, A., Biel, M. J. Biol. Chem. (2003) [Pubmed]
  6. Dependence of hyperpolarisation-activated cyclic nucleotide-gated channel activity on basal cyclic adenosine monophosphate production in spontaneously firing GH3 cells. Kretschmannova, K., Gonzalez-Iglesias, A.E., Tomić, M., Stojilkovic, S.S. J. Neuroendocrinol. (2006) [Pubmed]
  7. Hyperpolarization-activated cation channels are expressed in rat hypothalamic gonadotropin-releasing hormone (GnRH) neurons and immortalized GnRH neurons. Arroyo, A., Kim, B., Rasmusson, R.L., Bett, G., Yeh, J. J. Soc. Gynecol. Investig. (2006) [Pubmed]
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