Gene Review:
HCN1 - hyperpolarization activated cyclic...
Homo sapiens
Synonyms:
BCNG-1, BCNG1, Brain cyclic nucleotide-gated channel 1, EIEE24, HAC-2, ...
- Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. Bender, R.A., Soleymani, S.V., Brewster, A.L., Nguyen, S.T., Beck, H., Mathern, G.W., Baram, T.Z. J. Neurosci. (2003)
- Inherited cortical HCN1 channel loss amplifies dendritic calcium electrogenesis and burst firing in a rat absence epilepsy model. Kole, M.H., Bräuer, A.U., Stuart, G.J. J. Physiol. (Lond.) (2007)
- Human cerebral cortical cell lines from patients with unilateral megalencephaly and Rasmussen's encephalitis. Ronnett, G.V., Hester, L.D., Nye, J.S., Snyder, S.H. Neuroscience (1994)
- Mechanism of cross-resistance to a camptothecin analogue (CPT-11) in a human ovarian cancer cell line selected by cisplatin. Niimi, S., Nakagawa, K., Sugimoto, Y., Nishio, K., Fujiwara, Y., Yokoyama, S., Terashima, Y., Saijo, N. Cancer Res. (1992)
- Activity of docetaxel in paclitaxel-resistant ovarian cancer cells. Sato, S., Kigawa, J., Kanamori, Y., Itamochi, H., Oishi, T., Shimada, M., Iba, T., Naniwa, J., Uegaki, K., Terakawa, N. Cancer Chemother. Pharmacol. (2004)
- Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli. Stevens, D.R., Seifert, R., Bufe, B., Müller, F., Kremmer, E., Gauss, R., Meyerhof, W., Kaupp, U.B., Lindemann, B. Nature (2001)
- Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Santoro, B., Grant, S.G., Bartsch, D., Kandel, E.R. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Dipyridamole enhances an anti-proliferative effect of interferon in various types of human tumor cells. Suzuki, N., Oiwa, Y., Sugano, I., Inaba, N., Sekiya, S., Fukazawa, I., Yoshida, J., Takakubo, Y., Isogai, E., Saito-Ebihara, M. Int. J. Cancer (1992)
- Non-equilibrium behavior of HCN channels: insights into the role of HCN channels in native and engineered pacemakers. Azene, E.M., Xue, T., Marbán, E., Tomaselli, G.F., Li, R.A. Cardiovasc. Res. (2005)
- Low affinity block of native and cloned hyperpolarization-activated Ih channels by Ba2+ ions. van Welie, I., Wadman, W.J., van Hooft, J.A. Eur. J. Pharmacol. (2005)
- An interactive tool for extracting exons and SNP from genomic sequence: isolation of HCN1 and HCN3 ion channel genes. Liu, Y., Wang, Y., Folander, K., Xie, G., Blevins, R. Journal of bioinformatics and computational biology. (2003)
- Functional heteromerization of HCN1 and HCN2 pacemaker channels. Ulens, C., Tytgat, J. J. Biol. Chem. (2001)
- Hyperpolarization-activated cyclic nucleotide-gated channel 1 is a molecular determinant of the cardiac pacemaker current I(f). Moroni, A., Gorza, L., Beltrame, M., Gravante, B., Vaccari, T., Bianchi, M.E., Altomare, C., Longhi, R., Heurteaux, C., Vitadello, M., Malgaroli, A., DiFrancesco, D. J. Biol. Chem. (2001)
- Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction. Santoro, B., Wainger, B.J., Siegelbaum, S.A. J. Neurosci. (2004)
- Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. Cacheaux, L.P., Topf, N., Tibbs, G.R., Schaefer, U.R., Levi, R., Harrison, N.L., Abbott, G.W., Goldstein, P.A. J. Pharmacol. Exp. Ther. (2005)
- Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels. Bucchi, A., Tognati, A., Milanesi, R., Baruscotti, M., Difrancesco, D. J. Physiol. (Lond.) (2006)
- Characterization of the human HCN1 channel and its inhibition by capsazepine. Gill, C.H., Randall, A., Bates, S.A., Hill, K., Owen, D., Larkman, P.M., Cairns, W., Yusaf, S.P., Murdock, P.R., Strijbos, P.J., Powell, A.J., Benham, C.D., Davies, C.H. Br. J. Pharmacol. (2004)
- Hyperpolarization-activated, cyclic AMP-gated, HCN1-like cation channel: the primary, full-length HCN isoform expressed in a saccular hair-cell layer. Cho, W.J., Drescher, M.J., Hatfield, J.S., Bessert, D.A., Skoff, R.P., Drescher, D.G. Neuroscience (2003)
- Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels. Much, B., Wahl-Schott, C., Zong, X., Schneider, A., Baumann, L., Moosmang, S., Ludwig, A., Biel, M. J. Biol. Chem. (2003)
- The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides. Mistrík, P., Mader, R., Michalakis, S., Weidinger, M., Pfeifer, A., Biel, M. J. Biol. Chem. (2005)
- Distribution of constitutively expressed MEF-2A in adult rat and human nervous systems. Ruffle, R.A., Mapley, A.C., Malik, M.K., Labruzzo, S.V., Chabla, J.M., Jose, R., Hallas, B.H., Yu, H.G., Horowitz, J.M., Torres, G. Synapse (2006)
- Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels. Proenza, C., Tran, N., Angoli, D., Zahynacz, K., Balcar, P., Accili, E.A. J. Biol. Chem. (2002)
- Environmental manipulations early in development alter seizure activity, Ih and HCN1 protein expression later in life. Schridde, U., Strauss, U., Bräuer, A.U., van Luijtelaar, G. Eur. J. Neurosci. (2006)
- Establishment of a CPT-11-resistant human ovarian cancer cell line. Kijima, T., Kubota, N., Nishio, K. Anticancer Res. (1994)