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Chemical Compound Review

Cesium-127     cesium

Synonyms: AC1O3TH3, 127Cs, 15720-35-1, Cesium, isotope of mass 127
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Disease relevance of cesium


Psychiatry related information on cesium

  • Results showed significant increases in chlorine, iron, manganese, sodium, and phosphorus and significant decreases in chromium, cesium, rubidium, and selenium and in the mean freeze-dried to wet-weight ratio for patients with Pick's disease compared with control patients [5].
  • Given sufficient reaction time, metaschoepite was completely transformed to a clarkeite-like sodium uranyl oxide hydrate or a cesium uranyl oxide hydrate that has not previously been described [6].
  • A pattern of clinical trials suggests the potential of cesium salts in certain cancer therapies, affective disorders, tumor imaging, radiotherapy and certain cardiovascular usages [7].
  • Daily intakes of 232Th, 238U, and cesium differed statistically between northern and southern of Vietnam, depending on geological conditions and food habits [8].

High impact information on cesium

  • The apparent affinity of origin DNA for membranes is enhanced by two peptides, (55 kilodaltons (kd) and 75 kd), which remain attached to the DNA through treatment with 5.5 M cesium chloride [9].
  • Single-channel analyses with cell-attached patches revealed that Mid1 acts as a calcium-permeable, cation-selective stretch-activated channel with a conductance of 32 picosiemens at 150 millimolar cesium chloride in the pipette [10].
  • Radioactive cesium from the Chernobyl accident in the Greenland Ice Sheet [11].
  • We measured the effects of changing internal cesium (Cs+) and external sodium (Na+) concentrations on the channel-blocking kinetics of the adamantane derivatives IEM-1754 and IEM-1857 [12].
  • The early (5 min) endogenous reverse transcriptase product was analyzed by cesium sulfate gradient centrifugation [13].

Chemical compound and disease context of cesium


Biological context of cesium


Anatomical context of cesium

  • The quantitative preservation of satellite NA was studied in several central nervous system (CNS) neoplasms; four tumor lines deriveo from 3-methylcholanthrene implantation into the CNS of mice were compared with brain and tissue cultures of normal mouse cells by analytical centrifugation in cesium chlorie [23].
  • HT-29 cells were subjected to 12 Gy gamma-irradiation in a cesium irradiator [24].
  • Thirty minutes after the injection, cesium levels in Purkinje fibers were 5.3 +/- 1.0 mM/kg, levels in ventricular muscle were 4.6 +/- 0.9 mM/kg, and levels in atrial muscle were 4.1 +/- 0.8 mM/kg [1].
  • Gamma rays from a cesium source were used to generate human lymphoblastoid cell line variants that had lost expression of all major histocompatibility complex antigens coded for by a single haplotype [25].
  • The six proteins form functional potassium selective channels in Xenopus oocytes with different properties including altered current kinetics and inhibition by cesium [26].

Associations of cesium with other chemical compounds


Gene context of cesium


Analytical, diagnostic and therapeutic context of cesium

  • On centrifugation in cesium chloride density gradients, most sulfated glycosaminoglycans and matrix proteins remained associated and were recovered at a density of 1.34 g/cm3 (greater or equal to 2 M CsCl) [37].
  • Isopycnic centrifugation in cesium chloride removed the remaining outer membrane protein contaminants [38].
  • Liver nuclear DNA, enriched in ribosomal DNA (rDNA) by one round of cesium salt density gradient centrifugation, was treated under buffered alkaline conditions to convert unstable AFB1-N7-guanine adducts to stable AFB1-formamidopyrimidine derivatives [39].
  • In eight isolated endocardial preparations from canine ventricles, standard microelectrode techniques were used to study the effects of superfusion with 5 mM cesium [1].
  • The patch-clamp technique was used to record I(f), ie, a barium-insensitive, cesium-sensitive, time-dependent increasing inward current elicited on hyperpolarization [40].


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  2. Differential response to right and left ansae subclaviae stimulation of early afterdepolarizations and ventricular tachycardia induced by cesium in dogs. Ben-David, J., Zipes, D.P. Circulation (1988) [Pubmed]
  3. Magnesium suppression of early afterdepolarizations and ventricular tachyarrhythmias induced by cesium in dogs. Bailie, D.S., Inoue, H., Kaseda, S., Ben-David, J., Zipes, D.P. Circulation (1988) [Pubmed]
  4. Autonomic modulation of ventricular arrhythmia in cesium chloride-induced long QT syndrome. Hanich, R.F., Levine, J.H., Spear, J.F., Moore, E.N. Circulation (1988) [Pubmed]
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  9. Binding of the origin of replication of Escherichia coli to the outer membrane. Hendrickson, W.G., Kusano, T., Yamaki, H., Balakrishnan, R., King, M., Murchie, J., Schaechter, M. Cell (1982) [Pubmed]
  10. Molecular identification of a eukaryotic, stretch-activated nonselective cation channel. Kanzaki, M., Nagasawa, M., Kojima, I., Sato, C., Naruse, K., Sokabe, M., Iida, H. Science (1999) [Pubmed]
  11. Radioactive cesium from the Chernobyl accident in the Greenland Ice Sheet. Davidson, C.I., Harrington, J.R., Stephenson, M.J., Monaghan, M.C., Pudykiewicz, J., Schell, W.R. Science (1987) [Pubmed]
  12. Binding sites for permeant ions in the channel of NMDA receptors and their effects on channel block. Antonov, S.M., Gmiro, V.E., Johnson, J.W. Nat. Neurosci. (1998) [Pubmed]
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  15. Purification of the major sialoglycoproteins of 13762 MAT-B1 and MAT-C1 rat ascites mammary adenocarcinoma cells by density gradient centrifugation in cesium chloride and guanidine hydrochloride. Sherblom, A.P., Buck, R.L., Carraway, K.L. J. Biol. Chem. (1980) [Pubmed]
  16. Protease inhibitors suppress the formation of tight junctions in gastrointestinal cell lines. Bacher, A., Griebl, K., Mackamul, S., Mitreiter, R., Mückter, H., Ben-Shaul, Y. Exp. Cell Res. (1992) [Pubmed]
  17. Polypeptide composition of extracellular enveloped vaccinia virus. Payne, L. J. Virol. (1978) [Pubmed]
  18. Effect of tunicamycin on rotavirus assembly and infectivity. Sabara, M., Babiuk, L.A., Gilchrist, J., Misra, V. J. Virol. (1982) [Pubmed]
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  20. Early replicative intermediates of Escherichia coli chromosome isolated from a membrane complex. Yoshimoto, M., Kambe-Honjoh, H., Nagai, K., Tamura, G. EMBO J. (1986) [Pubmed]
  21. Effects of pacing on triggered activity induced by early afterdepolarizations. Damiano, B.P., Rosen, M.R. Circulation (1984) [Pubmed]
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  23. Amount of satellite DNA in four experimentally induced tumors of the central nervous system. Quantitative changes in a glioblastoma producing C-type particles. Manuelidis, L., Manuelidis, E.E. J. Natl. Cancer Inst. (1976) [Pubmed]
  24. Functional Antagonism Between RNA Binding Proteins HuR and CUGBP2 Determines the Fate of COX-2 mRNA Translation. Sureban, S.M., Murmu, N., Rodriguez, P., May, R., Maheshwari, R., Dieckgraefe, B.K., Houchen, C.W., Anant, S. Gastroenterology (2007) [Pubmed]
  25. Gamma ray-induced loss of expression of HLA and glyoxalase I alleles in lymphoblastoid cells. Kavathas, P., Bach, F.H., DeMars, R. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  26. Small potassium ion channel proteins encoded by chlorella viruses. Kang, M., Moroni, A., Gazzarrini, S., DiFrancesco, D., Thiel, G., Severino, M., Van Etten, J.L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  27. Aberrant expression of monoclonal antibody-defined colonic mucosal antigens in inflammatory bowel disease. Haviland, A.E., Borowitz, M.J., Lan, M.S., Kaufman, B., Khorrami, A., Phelps, P.C., Metzgar, R.S. Gastroenterology (1988) [Pubmed]
  28. Immunological characterization of a basement membrane-specific chondroitin sulfate proteoglycan. McCarthy, K.J., Accavitti, M.A., Couchman, J.R. J. Cell Biol. (1989) [Pubmed]
  29. Isolation and characterization of germ line DNA from mouse sperm. Shiurba, R., Nandi, S. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  30. Right-handed alternating DNA conformation: poly(dA-dT) adopts the same dinucleotide repeat with cesium, tetraalkylammonium, and 3 alpha, 5 beta, 17 beta-dipyrrolidinium steroid dimethiodide cations in aqueous solution. Patel, D.J., Kozlowski, S.A., Suggs, J.W., Cox, S.D. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  31. Perturbation of DNA replication and cell cycle progression by commonly used [3H]thymidine labeling protocols. Hoy, C.A., Lewis, E.D., Schimke, R.T. Mol. Cell. Biol. (1990) [Pubmed]
  32. Functional expression of the human HCN3 channel. Stieber, J., Stöckl, G., Herrmann, S., Hassfurth, B., Hofmann, F. J. Biol. Chem. (2005) [Pubmed]
  33. Isolation and characterization of the small nucleolar ribonucleoprotein particle snR30 from Saccharomyces cerevisiae. Lübben, B., Fabrizio, P., Kastner, B., Lührmann, R. J. Biol. Chem. (1995) [Pubmed]
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  35. G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons. Torrecilla, M., Marker, C.L., Cintora, S.C., Stoffel, M., Williams, J.T., Wickman, K. J. Neurosci. (2002) [Pubmed]
  36. Quantitative RT-PCR assay for MUC3 and VEGF mRNA in renal clear cell carcinoma: relationship with nuclear grade and prognosis. Leroy, X., Gouyer, V., Ballereau, C., Zerimech, F., Huet, G., Copin, M.C., Aubert, J.P., Porchet, N. Urology (2003) [Pubmed]
  37. Structure of the pericellular matrix: association of heparan and chondroitin sulfates with fibronectin-procollagen fibers. Hedman, K., Johansson, S., Vartio, T., Kjellén, L., Vaheri, A., Höök, M. Cell (1982) [Pubmed]
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  39. Quantitation of aflatoxin B1 adduction within the ribosomal RNA gene sequences of rat liver DNA. Irvin, T.R., Wogan, G.N. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  40. Characterization of the hyperpolarization-activated current, I(f), in ventricular myocytes from human failing heart. Cerbai, E., Pino, R., Porciatti, F., Sani, G., Toscano, M., Maccherini, M., Giunti, G., Mugelli, A. Circulation (1997) [Pubmed]
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