Chemical Compound Review:
Ivabradine 4-[3-[[(8R)-3,4-dimethoxy-8...
Synonyms:
Procoralan, SureCN23472, CHEMBL471737, CHEBI:548872, LS-28023, ...
Camm,
Lau,
Portolés,
Terleira,
Calvo,
Martínez,
Resplandy,
Thollon,
Bedut,
Villeneuve,
Cog??,
Piffard,
Guillaumin,
Brunel-Jacquemin,
Chomarat,
Boutin,
Peglion,
Vilaine,
Portolés,
Calvo,
Terleira,
Laredo,
Resplandy,
Gorostiaga,
Moreno,
Palatini,
Benetos,
Julius,
Stieber,
Wieland,
Stöckl,
Ludwig,
Hofmann,
DiFrancesco,
Tardif,
Ford,
Tendera,
Bourassa,
Fox,
Vilaine,
Bidouard,
Lesage,
Reure,
Péglion,
Langenbach,
Schmitz-Spanke,
Brockert,
Schepan,
Pomblum,
Gams,
Zirngibl,
Schipke,
- Heart rate reduction during exercise-induced myocardial ischaemia and stunning. Monnet, X., Colin, P., Ghaleh, B., Hittinger, L., Giudicelli, J.F., Berdeaux, A. Eur. Heart J. (2004)
- Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease. DiFrancesco, D., Camm, J.A. Drugs (2004)
- Effects of heart rate reduction with ivabradine on exercise-induced myocardial ischemia and stunning. Monnet, X., Ghaleh, B., Colin, P., de Curzon, O.P., Giudicelli, J.F., Berdeaux, A. J. Pharmacol. Exp. Ther. (2001)
- Coronary and hemodynamic effects of S 16257, a new bradycardic agent, in resting and exercising conscious dogs. Simon, L., Ghaleh, B., Puybasset, L., Giudicelli, J.F., Berdeaux, A. J. Pharmacol. Exp. Ther. (1995)
- Serious workings of the funny current. DiFrancesco, D. Prog. Biophys. Mol. Biol. (2006)
- The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides. Mistrík, P., Mader, R., Michalakis, S., Weidinger, M., Pfeifer, A., Biel, M. J. Biol. Chem. (2005)
- Bradycardic and proarrhythmic properties of sinus node inhibitors. Stieber, J., Wieland, K., Stöckl, G., Ludwig, A., Hofmann, F. Mol. Pharmacol. (2006)
- Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina. Tardif, J.C., Ford, I., Tendera, M., Bourassa, M.G., Fox, K. Eur. Heart J. (2005)
- Anti-ischemic effects of ivabradine, a selective heart rate-reducing agent, in exercise-induced myocardial ischemia in pigs. Vilaine, J.P., Bidouard, J.P., Lesage, L., Reure, H., Péglion, J.L. J. Cardiovasc. Pharmacol. (2003)
- Comparison of a b-blocker and an if current inhibitor in rabbits with myocardial infarction. Langenbach, M.R., Schmitz-Spanke, S., Brockert, M., Schepan, M., Pomblum, V.J., Gams, E., Zirngibl, H., Schipke, J.D. The Journal of cardiovascular surgery. (2006)
- Impact of increased heart rate on clinical outcomes in hypertension: implications for antihypertensive drug therapy. Palatini, P., Benetos, A., Julius, S. Drugs (2006)
- Effect of graded heart rate reduction with ivabradine on myocardial oxygen consumption and diastolic time in exercising dogs. Colin, P., Ghaleh, B., Monnet, X., Hittinger, L., Berdeaux, A. J. Pharmacol. Exp. Ther. (2004)
- Use-dependent inhibition of hHCN4 by ivabradine and relationship with reduction in pacemaker activity. Thollon, C., Bedut, S., Villeneuve, N., Cog??, F., Piffard, L., Guillaumin, J.P., Brunel-Jacquemin, C., Chomarat, P., Boutin, J.A., Peglion, J.L., Vilaine, J.P. Br. J. Pharmacol. (2007)
- Lack of pharmacokinetic interaction between omeprazole or lansoprazole and ivabradine in healthy volunteers: an open-label, randomized, crossover, pharmacokinetic interaction clinical trial. Portolés, A., Calvo, A., Terleira, A., Laredo, L., Resplandy, G., Gorostiaga, C., Moreno, A. Journal of clinical pharmacology. (2006)
- Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine. Bucchi, A., Baruscotti, M., DiFrancesco, D. J. Gen. Physiol. (2002)
- Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49. Thollon, C., Cambarrat, C., Vian, J., Prost, J.F., Peglion, J.L., Vilaine, J.P. Br. J. Pharmacol. (1994)
- Mechanisms of block of a human cloned potassium channel by the enantiomers of a new bradycardic agent: S-16257-2 and S-16260-2. Delpón, E., Valenzuela, C., Pérez, O., Franqueza, L., Gay, P., Snyders, D.J., Tamargo, J. Br. J. Pharmacol. (1996)
- Effect of chronic heart rate reduction with ivabradine on carotid and aortic structure and function in normotensive and hypertensive rats. Albaladejo, P., Carusi, A., Apartian, A., Lacolley, P., Safar, M.E., Bénétos, A. J. Vasc. Res. (2003)
- Clinical Effect of 'Pure' Heart Rate Slowing with a Prototype I (f) Current Inhibitor: Placebo-Controlled Experience with Ivabradine. Borer, J.S. Advances in cardiology. (2006)
- Novel I(f) Current Inhibitor Ivabradine: Safety Considerations. Savelieva, I., Camm, A.J. Advances in cardiology. (2006)
- Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels. Bucchi, A., Tognati, A., Milanesi, R., Baruscotti, M., Difrancesco, D. J. Physiol. (Lond.) (2006)
- Effects of Hypericum perforatum on Ivabradine Pharmacokinetics in Healthy Volunteers: An Open-Label, Pharmacokinetic Interaction Clinical Trial. Portolés, A., Terleira, A., Calvo, A., Martínez, I., Resplandy, G. Journal of clinical pharmacology. (2006)
- I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities. Du, X.J., Feng, X., Gao, X.M., Tan, T.P., Kiriazis, H., Dart, A.M. Br. J. Pharmacol. (2004)
- Simultaneous determination of ivabradine and its metabolites in human plasma by liquid chromatography--tandem mass spectrometry. François-Bouchard, M., Simonin, G., Bossant, n.u.l.l., Boursier-Neyret, C. J. Chromatogr. B Biomed. Sci. Appl. (2000)
- Electrophysiological effects of a single intravenous administration of ivabradine (S 16257) in adult patients with normal baseline electrophysiology. Camm, A.J., Lau, C.P. Drugs in R&D. (2003)
- Pharmacokinetic-pharmacodynamic modeling of the effects of ivabradine, a direct sinus node inhibitor, on heart rate in healthy volunteers. Ragueneau, I., Laveille, C., Jochemsen, R., Resplandy, G., Funck-Brentano, C., Jaillon, P. Clin. Pharmacol. Ther. (1998)
- Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells. Bois, P., Bescond, J., Renaudon, B., Lenfant, J. Br. J. Pharmacol. (1996)