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Gene Review

PTPN9  -  protein tyrosine phosphatase, non-receptor...

Homo sapiens

Synonyms: MEG2, PTPMEG2, PTPase MEG2, Protein-tyrosine phosphatase MEG2, Tyrosine-protein phosphatase non-receptor type 9
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High impact information on PTPN9


Biological context of PTPN9

  • BAC clones containing the PTPN9, and SLP-1[hUNC24] genes showed markedly reduced hybridization in the 15q22-q23 region on one chromosome 15 in the patient [5].
  • Hybridization of the PTPN9 and Slp-1 Bac clones to the 15q11-q13 and the 15q22-q23 regions of chromosome 15 may be due to the presence of PTPN9 or SLP-1 gene sequences or to the presence of other gene sequences or to non-coding homologous DNA sequences [5].

Associations of PTPN9 with chemical compounds


Analytical, diagnostic and therapeutic context of PTPN9


  1. Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p. Gu, M., Warshawsky, I., Majerus, P.W. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cells. Huynh, H., Wang, X., Li, W., Bottini, N., Williams, S., Nika, K., Ishihara, H., Godzik, A., Mustelin, T. J. Immunol. (2003) [Pubmed]
  3. Specific interaction of protein tyrosine phosphatase-MEG2 with phosphatidylserine. Zhao, R., Fu, X., Li, Q., Krantz, S.B., Zhao, Z.J. J. Biol. Chem. (2003) [Pubmed]
  4. Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides. Kruger, J.M., Fukushima, T., Cherepanov, V., Borregaard, N., Loeve, C., Shek, C., Sharma, K., Tanswell, A.K., Chow, C.W., Downey, G.P. J. Biol. Chem. (2002) [Pubmed]
  5. Analysis of a 1-megabase deletion in 15q22-q23 in an autistic patient: identification of candidate genes for autism and of homologous DNA segments in 15q22-q23 and 15q11-q13. Smith, M., Filipek, P.A., Wu, C., Bocian, M., Hakim, S., Modahl, C., Spence, M.A. Am. J. Med. Genet. (2000) [Pubmed]
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