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Gene Review

ZNF410  -  zinc finger protein 410

Homo sapiens

Synonyms: APA-1, APA1, Another partner for ARF 1, Zinc finger protein 410, Zinc finger protein APA-1
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Disease relevance of ZNF410

  • In our study, 2 restriction fragment length polymorphisms (RFLP) in the 3' region (detected by Apa1 and Taq1) and an initiation codon variant in the 5' end of the VDR gene (detected by Fok1) were tested for association with breast cancer risk in 135 females with sporadic breast cancer and 110 cancer-free female controls [1].
  • To clarify genomic imprinting of IGF2 in colorectal cancer, we examined loss of imprinting (LOI) and loss of heterozygosity (LOH) in surgically resected tissues by utilizing Apa1 polymorphism [2].

High impact information on ZNF410

  • Exposure of the APA1/1 epitope is shown to be fast and independent of tyrosine kinase activity and that it takes place even when T cells are stimulated at 0 degrees C. These results suggest that APA1/1 detects a conformational change in the TCR [3].
  • APA-1 was able to transactivate and bind to the MMP1 promoter, suggesting that APA-1 is a transcription factor that regulates expression of matrix-remodeling genes during fibroblast senescence [4].
  • By contrast, the antibodies SP34 and APA 1/1, which were raised against isolated SDS-denatured CD3-epsilon protein, gave a strong staining of COS cells singly transfected with CD3-epsilon as well as of the double transfectans [5].
  • The vitamin D receptor genotype using the restriction enzymes Bsm1, Taq1, and Apa1 was Bb, tt, and AA [6].
  • When compared with 101 controls, M. malmoense patients displayed an increased prevalence of Apa1 A (P=.03; Fisher's exact test), TaqI t (P=.04), and the At VDR haplotype (P=.04), and they displayed a decreased prevalence of FokI f (P=.04) [7].

Biological context of ZNF410

  • MMP1 and PAI2 transcript levels also increased in telomerase-immortalized fibroblasts that had high levels of APA-1, demonstrating that the matrix-remodeling phenotype of senescent fibroblasts was not induced by telomere attrition alone [4].
  • Allele frequencies of the 3' Apa1 polymorphism showed a significant association (p = 0.016; OR = 1.56, 95% CI = 1.09-2.24) while the Taq1 RFLP showed a similar trend (p = 0.053; OR = 1.45, 95% CI = 1.00-2.00) [1].

Anatomical context of ZNF410

  • Most important, we show that full agonist, but not partial agonist, peptides induce exposure of the APA1/1 epitope, indicating a correlation between the induction of the conformational change in the TCR and full T-cell activation [3].

Associations of ZNF410 with chemical compounds


Analytical, diagnostic and therapeutic context of ZNF410


  1. Association of A vitamin D receptor polymorphism with sporadic breast cancer development. Curran, J.E., Vaughan, T., Lea, R.A., Weinstein, S.R., Morrison, N.A., Griffiths, L.R. Int. J. Cancer (1999) [Pubmed]
  2. Analysis of genomic imprinting of insulin-like growth factor 2 in colorectal cancer. Takano, Y., Shiota, G., Kawasaki, H. Oncology (2000) [Pubmed]
  3. Ligand-induced conformational change in the T-cell receptor associated with productive immune synapses. Risueño, R.M., Gil, D., Fernández, E., Sánchez-Madrid, F., Alarcón, B. Blood (2005) [Pubmed]
  4. Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1. Benanti, J.A., Williams, D.K., Robinson, K.L., Ozer, H.L., Galloway, D.A. Mol. Cell. Biol. (2002) [Pubmed]
  5. A conformational epitope expressed upon association of CD3-epsilon with either CD3-delta or CD3-gamma is the main target for recognition by anti-CD3 monoclonal antibodies. Salmerón, A., Sánchez-Madrid, F., Ursa, M.A., Fresno, M., Alarcón, B. J. Immunol. (1991) [Pubmed]
  6. Regression of skeletal manifestations of hyperparathyroidism with oral vitamin D. Arabi, A., Khoury, N., Zahed, L., Birbari, A., El-Hajj Fuleihan, G. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  7. Vitamin D receptor gene polymorphisms and susceptibility to Mycobacterium malmoense pulmonary disease. Gelder, C.M., Hart, K.W., Williams, O.M., Lyons, E., Welsh, K.I., Campbell, I.A., Marshall, S.E. J. Infect. Dis. (2000) [Pubmed]
  8. Controlling biofilm formation with an N-halamine-based polymeric additive. Luo, J., Chen, Z., Sun, Y. Journal of biomedical materials research. Part A. (2006) [Pubmed]
  9. High prevalence of mitochondrial diabetes mellitus in Japanese patients with major risk factors. Fukui, M., Nakano, K., Obayashi, H., Kitagawa, Y., Nakamura, N., Mori, H., Kajiyama, S., Wada, S., Fujii, M., Yoshimori, K., Kanaitsuka, T., Shigeta, H., Kondo, M. Metab. Clin. Exp. (1997) [Pubmed]
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