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Gene Review

Nr4a3  -  nuclear receptor subfamily 4, group A,...

Rattus norvegicus

Synonyms: Neuron-derived orphan receptor 1/2, Nor1, Nuclear hormone receptor NOR-1/NOR-2, Nuclear receptor subfamily 4 group A member 3
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High impact information on Nr4a3

  • Re-exposure to the cue after 3 weeks of withdrawal reinstated heroin-seeking behaviour, which resulted in IEG expression of ania-3, MKP-1, c-fos and Nr4a3 in the medial prefrontal cortex (mPFC), and of ania-3 in the orbital frontal cortex (OFC) and nucleus accumbens core (NAC) [1].
  • Among these genes, we are particularly interested in Nor-1, because this gene belongs to the Nur77 family, which plays a key role in the apoptotic processes of a variety of cells and tissues, including the lung [2].
  • Nur77, Nor-1 and Nurr1 were all induced after cadmium treatment in a dose- and time-dependent manner in WI-38 and A549 lung cell lines [2].
  • Acute haloperidol treatment increased NGFI-B, Nor1 and c-fos mRNAs in nucleus accumbens shell and core as well as medial and lateral caudate putamen [3].
  • Morphine increased NGFI-B mRNA in medial caudate putamen and cortex cinguli in Lewis rats and Nor1 mRNA in medial caudate putamen in Fischer rats [4].

Biological context of Nr4a3

  • In contrast, naloxone had no effect on Nor1 mRNA levels, although the running-induced downregulation of Nor1 was, in most cases, attenuated by naloxone [5].

Anatomical context of Nr4a3

  • In contrast, Nor1 mRNA levels were upregulated in Lewis rats in medial caudate putamen and cingulate cortex after chronic cocaine and in cingulate cortex after chronic morphine [4].
  • After 30 d of running, levels of mRNA encoding NGFI-B and Nor1 were decreased in cerebral cortex in Lewis but not Fischer rats [5].

Associations of Nr4a3 with chemical compounds

  • In contrast, Nor1 mRNA was only significantly upregulated by cocaine in the Fischer rats [4].
  • Differential patterns of induction of NGFI-B, Nor1 and c-fos mRNAs in striatal subregions by haloperidol and clozapine [3].
  • Major metabolites, CPZ sulfoxide, Nor1 -CPZ and Nor2 -CPZ are not bound significantly by the antibody unless the concentrations are very high [6].


  1. Enhanced cortical and accumbal molecular reactivity associated with conditioned heroin, but not sucrose-seeking behaviour. Koya, E., Spijker, S., Voorn, P., Binnekade, R., Schmidt, E.D., Schoffelmeer, A.N., De Vries, T.J., Smit, A.B. J. Neurochem. (2006) [Pubmed]
  2. Induction of orphan nuclear receptor Nur77 gene expression and its role in cadmium-induced apoptosis in lung. Shin, H.J., Lee, B.H., Yeo, M.G., Oh, S.H., Park, J.D., Park, K.K., Chung, J.H., Moon, C.K., Lee, M.O. Carcinogenesis (2004) [Pubmed]
  3. Differential patterns of induction of NGFI-B, Nor1 and c-fos mRNAs in striatal subregions by haloperidol and clozapine. Werme, M., Ringholm, A., Olson, L., Brené, S. Brain Res. (2000) [Pubmed]
  4. NGFI-B and nor1 mRNAs are upregulated in brain reward pathways by drugs of abuse: different effects in Fischer and Lewis rats. Werme, M., Olson, L., Brené, S. Brain Res. Mol. Brain Res. (2000) [Pubmed]
  5. Addiction-prone Lewis but not Fischer rats develop compulsive running that coincides with downregulation of nerve growth factor inducible-B and neuron-derived orphan receptor 1. Werme, M., Thorén, P., Olson, L., Brené, S. J. Neurosci. (1999) [Pubmed]
  6. Development of radioimmunoassay for chlorpromazine. Kawashima, K., Dixon, R., Spector, S. Eur. J. Pharmacol. (1975) [Pubmed]
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