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Gene Review

TMEM8A  -  transmembrane protein 8A

Homo sapiens

Synonyms: M83, Protein M83, TMEM6, TMEM8, Transmembrane protein 6, ...
 
 
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Disease relevance of TMEM8

  • The M83 ORF is also expressed at high levels in cells infected by a recombinant vaccinia virus and yields a protein which is serologically cross-reactive and comigrates with the authentic MCMV protein in sodium dodecyl sulfate-polyacrylamide gel electrophoresis [1].
  • In this report, we show that unlike the M83 gene product, the M84 protein is expressed at early times in the infection and cannot be detected in the virion [2].
  • In vivo replication, latency, and immunogenicity of murine cytomegalovirus mutants with deletions in the M83 and M84 genes, the putative homologs of human cytomegalovirus pp65 (UL83) [2].
  • Cell kinetics and therapy in multiple myeloma: an update of the M83 protocol [3].
 

High impact information on TMEM8

 

Biological context of TMEM8

  • Case M83 displayed low-grade mosaicism for cells with an extra small ring of unknown origin [7].
 

Associations of TMEM8 with chemical compounds

  • A retrospective analysis was performed on two subsequent myeloma patient series treated with the same conventional induction treatments, melphalan and prednisone or alternating VMCP/VBAP: 273 were enrolled in the multicentre M83 trial (M83 trial group) from 1983 to 1986; 160 were referred to a single institution (Haemat.To group) from 1986 to 1994 [8].
 

Analytical, diagnostic and therapeutic context of TMEM8

  • Molecular cloning and chromosomal mapping of a novel five-span transmembrane protein gene, M83 [6].
  • Western blot analysis demonstrated that except for the absence of M83 or M84 protein expression in the respective mutants, no global perturbations of protein expression were detected [2].

References

  1. Identification, analysis, and evolutionary relationships of the putative murine cytomegalovirus homologs of the human cytomegalovirus UL82 (pp71) and UL83 (pp65) matrix phosphoproteins. Cranmer, L.D., Clark, C.L., Morello, C.S., Farrell, H.E., Rawlinson, W.D., Spector, D.H. J. Virol. (1996) [Pubmed]
  2. In vivo replication, latency, and immunogenicity of murine cytomegalovirus mutants with deletions in the M83 and M84 genes, the putative homologs of human cytomegalovirus pp65 (UL83). Morello, C.S., Cranmer, L.D., Spector, D.H. J. Virol. (1999) [Pubmed]
  3. Cell kinetics and therapy in multiple myeloma: an update of the M83 protocol. Pileri, A., Barbui, T., Boccadoro, M., Comotti, B., Dammacco, F., Gallamini, A., Marmont, F., Neretto, G., Petrucci, M.T., Resegotti, L. Bone Marrow Transplant. (1989) [Pubmed]
  4. Pesticide Exposure Exacerbates {alpha}-Synucleinopathy in an A53T Transgenic Mouse Model. Norris, E.H., Uryu, K., Leight, S., Giasson, B.I., Trojanowski, J.Q., Lee, V.M. Am. J. Pathol. (2007) [Pubmed]
  5. Experimental preemptive immunotherapy of murine cytomegalovirus disease with CD8 T-cell lines specific for ppM83 and pM84, the two homologs of human cytomegalovirus tegument protein ppUL83 (pp65). Holtappels, R., Podlech, J., Grzimek, N.K., Thomas, D., Pahl-Seibert, M.F., Reddehase, M.J. J. Virol. (2001) [Pubmed]
  6. Molecular cloning and chromosomal mapping of a novel five-span transmembrane protein gene, M83. Motohashi, T., Miyoshi, S., Osawa, M., Eyre, H.J., Sutherland, G.R., Matsuda, Y., Nakamura, Y., Shibuya, A., Iwama, A., Nakauchi, H. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  7. Cytogenetics of 50 patients with mental retardation and multiple congenital anomalies and 50 normal subjects. Madison blind study IV. Magnelli, N.C. Clin. Genet. (1976) [Pubmed]
  8. Conventional induction treatments do not influence overall survival in multiple myeloma. Boccadoro, M., Palumbo, A., Argentino, C., Dominietto, A., Frieri, R., Avvisati, G., Comotti, B., Lauta, V.M., Liberati, M., Marmont, F., Musto, P., Tribalto, M., Pileri, A. Br. J. Haematol. (1997) [Pubmed]
 
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