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Gene Review

Aoc1  -  amine oxidase, copper-containing 1

Mus musculus

Synonyms: 1600012D06Rik, Abp1, Amiloride-binding protein 1, Amine oxidase copper domain-containing protein 1, DAO, ...
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Disease relevance of Abp1

  • In addition, the therapeutic efficacy of ABPP and AIPP was also determined against spontaneous lung metastases of NFSa [1].
  • In addition, VP2 virion attachment to CrFK cells was blocked when the VP2 virions were preincubated with partially purified ABP [2].
  • Application of RA (10 micrograms/animal) 1 h prior to skin application of TPA, BPO, ABP or BPB afforded significant protection (up to 70%) only against malignant conversion mediated by free radical-generating compounds in both chemically induced and UVB-induced benign skin papillomas [3].
  • BAF1 mice given three daily injections of ABMP, ABPP (as well as of the interferon-inducer poly I:C) demonstrated enhanced anti-listerial resistance, as measured by a 100-fold increase in the median lethal dose of Listeria compared to vehicle-treated control mice [4].
  • We found that radiation induced changes in plasma diamine oxidase activity; monitoring these changes was a useful indicator of the severity of radiation injury [5].

Psychiatry related information on Abp1

  • Administrations of ABPP (200 mg/kg or 500 mg/kg) at intervals of 2 days and the injection of IFN (25,000 IU/mouse) 3 hr before each administration of ABPP to neuroblastoma-bearing A/J mice reduced the mortality and completely cured 40% of the mice in each combined therapy group [6].

High impact information on Abp1


Chemical compound and disease context of Abp1

  • The modulation of murine host resistance to infection with Listeria monocytogenes by the substituted pyrimidine anti-viral compounds, 2-amino-5-bromo-6-methyl-4-pyrimidinol (ABMP), 2-amino-5-bromo-6-phenyl-4-pyrimidinol (ABPP) and 2-amino-5-iodo-6-phenyl-4-pyrimidinol (AIPP) was investigated [4].

Biological context of Abp1

  • The VP2 virions were used in a virus overlay protein binding assay to identify a single protein of approximately 67 kDa, named ABP (for ADV binding protein), that demonstrates specific binding of VP2 virions [2].
  • This suggests a role for a diamine oxidase-like enzyme in the oxidative deamination of spermidine and N1-acetylspermidine [11].
  • Anaerobiosis or inhibition of monoamineoxidase (MAO) activity significantly reduced 14CO2 formation in every organ, but inhibition of diamine oxidase (DAO) activity had no effect in brain and kidney [12].
  • The analysis of the behavioral traits: peripheral and central activities, leaning, rearing and defecation in the parental strains made it possible to show that the ABP/Le strain was more reactive than C57BL/6By [13].
  • The proportion of cells bearing Lyt-2 was altered by only two drugs; cyclophosphamide increased both Lyt-1+2+ and Lyt-1-2+ spleen cells and ABPP (an interferon inducer which stimulates antibody formation) decreased both Lyt-2+ subpopulations [14].

Anatomical context of Abp1

  • The activity of diamine oxidase, the major enzyme involved in Put catabolism, was comparable in the two cell lines even though the Put content of the transgenic cells was severalfold higher than the NT cells [15].
  • Inhibition of S-adenosylmethionine decarboxylase and diamine oxidase activities by analogues of methylglyoxal bis(guanylhydrazone) and their cellular uptake during lymphocyte activation [16].
  • Moreover, approximately 50% of intracellular ABP was found associated with lysosomes after isopycnic centrifugation of cell homogenates in isoosmotic Percoll or hyperosmotic sucrose gradients [17].
  • We therefore synthesized a basic derivative of penicillin G, namely, 14C-labeled N-(3-dimethylamino-propyl)benzylpenicillinamide (ABP), and studied its uptake and subcellular localization in J774 macrophages compared with that of 14C-labeled penicillin G [17].
  • Moreover, maltase and diamine oxidase activities of intestinal epithelium remained higher with combined treatment than with FF-705 alone [18].

Associations of Abp1 with chemical compounds

  • We have confirmed that this strain lacks DAO activity and shown for the first time it has increased occupancy of the NMDAR glycine site due to elevated extracellular D-serine levels and has enhanced NMDAR function in vivo [19].
  • It is concluded that in poplar cells: (a) exogenously supplied Orn enters the cells and is rapidly converted into Put, (b) the rate of Put catabolism is proportional to the rate of its biosynthesis, and (c) the increased Put degradation occurs without significant changes in the activity of diamine oxidase [15].
  • Glyoxal bis(guanylhydrazone) inhibited diamine oxidase (EC activity as effectively as did methylglyoxal bis(guanylhydrazone) [20].
  • Imiquimod stimulated significantly higher levels of IFN when compared with 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP) and similar levels of IFN when compared with tilorone [21].
  • Whereas the intracellular concentration (Ci) of penicillin G remained lower than its extracellular concentration (Ce), ABP reached a Ci/Ce ratio of 4 to 5 [17].

Regulatory relationships of Abp1


Other interactions of Abp1


Analytical, diagnostic and therapeutic context of Abp1


  1. Studies on the antitumor activities of pyrimidinone-interferon inducers. I. Effect against artificial and spontaneous lung metastases of murine tumors. Milas, L., Hersh, E.M., Stringfellow, D.A., Hunter, N. J. Natl. Cancer Inst. (1982) [Pubmed]
  2. Identification of a cell surface protein from Crandell feline kidney cells that specifically binds Aleutian mink disease parvovirus. Fox, J.M., Bloom, M.E. J. Virol. (1999) [Pubmed]
  3. All-trans retinoic acid protects against conversion of chemically induced and ultraviolet B radiation-induced skin papillomas to carcinomas. Athar, M., Agarwal, R., Wang, Z.Y., Lloyd, J.R., Bickers, D.R., Mukhtar, H. Carcinogenesis (1991) [Pubmed]
  4. Enhancement of resistance to Listeria monocytogenes infection in mice by pyrimidine analogs. Anthony, L.S., Stevenson, M.M., Skamene, E. Clinical and investigative medicine. Médecine clinique et experimentale. (1984) [Pubmed]
  5. Therapies for radiation injuries: research perspectives. Brook, I., Ledney, G.D., Madonna, G.S., DeBell, R.M., Walker, R.I. Military medicine. (1992) [Pubmed]
  6. Interferon counteracts pyrimidinone-induced hyporeactivity and the combined treatment has antitumor effect in mice. Oku, T., Imanishi, J., Kishida, T. Gann = Gan. (1984) [Pubmed]
  7. Identification, purification, and molecular cloning of autonomously replicating sequence-binding protein 1 from fission yeast Schizosaccharomyces pombe. Murakami, Y., Huberman, J.A., Hurwitz, J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  8. Piecemeal degranulation of mast cells in the inflammatory eyelid lesions of interleukin-4 transgenic mice. Evidence of mast cell histamine release in vivo by diamine oxidase-gold enzyme-affinity ultrastructural cytochemistry. Dvorak, A.M., Tepper, R.I., Weller, P.F., Morgan, E.S., Estrella, P., Monahan-Earley, R.A., Galli, S.J. Blood (1994) [Pubmed]
  9. The role of polyamine biosynthesis in hematopoietic precursor cell proliferation in mice. Niskanen, E., Kallio, A., McCann, P.P., Baker, D.G. Blood (1983) [Pubmed]
  10. Inhibitory effects of interferon-inducing pyrimidinones on the growth of transplantable mouse bladder tumors. Sidky, Y.A., Borden, E.C., Wierenga, W., Bryan, G.T. Cancer Res. (1986) [Pubmed]
  11. N-(3-aminopropyl)pyrrolidin-2-one, a product of spermidine catabolism in vivo. Seiler, N., Knödgen, B., Haegele, K. Biochem. J. (1982) [Pubmed]
  12. Metabolism of cadaverine and pipecolic acid in brain and other organs of the mouse. Nomura, Y., Schmidt-Glenewinkel, T., Giacobini, E., Ortiz, J. J. Neurosci. Res. (1983) [Pubmed]
  13. Involvement of regions of the 4th and 7th chromosomes in the open-field activity of mice. Clément, Y., Martin, B., Venault, P., Chapouthier, G. Behav. Brain Res. (1995) [Pubmed]
  14. Effects of treatment with immunomodulatory drugs on thymus and spleen lymphocyte subpopulations and serum corticosterone levels. Fast, P.E., Hatfield, C.A., Franz, C.L., Adams, E.G., Licht, N.J., Merritt, M.V. Immunopharmacology (1982) [Pubmed]
  15. Genetic manipulation of the metabolism of polyamines in poplar cells. The regulation of putrescine catabolism. Bhatnagar, P., Minocha, R., Minocha, S.C. Plant Physiol. (2002) [Pubmed]
  16. Inhibition of S-adenosylmethionine decarboxylase and diamine oxidase activities by analogues of methylglyoxal bis(guanylhydrazone) and their cellular uptake during lymphocyte activation. Jänne, J., Morris, D.R. Biochem. J. (1984) [Pubmed]
  17. Influence of conversion of penicillin G into a basic derivative on its accumulation and subcellular localization in cultured macrophages. Renard, C., Vanderhaeghe, H.J., Claes, P.J., Zenebergh, A., Tulkens, P.M. Antimicrob. Agents Chemother. (1987) [Pubmed]
  18. Alleviation of intestinal lesions by combined treatment with a 5-fluoro-2'-deoxyuridine (FUDR) derivative and alpha-difluoromethylornithine (DFMO)[correction of DMFO] in tumor-bearing mice. Takeshita, S., Nagatomi, H., Ando, K. Biochem. Pharmacol. (1992) [Pubmed]
  19. Behavioral and biochemical characterization of a mutant mouse strain lacking D-amino acid oxidase activity and its implications for schizophrenia. Almond, S.L., Fradley, R.L., Armstrong, E.J., Heavens, R.B., Rutter, A.R., Newman, R.J., Chiu, C.S., Konno, R., Hutson, P.H., Brandon, N.J. Mol. Cell. Neurosci. (2006) [Pubmed]
  20. Glyoxal bis(guanylhydrazone) as an inhibitor of polyamine biosynthesis in tumour cells. Seppänen, P., Fagerström, R., Alhonen-Hongisto, L., Elo, H., Lumme, P., Jänne, J. Biochem. J. (1984) [Pubmed]
  21. Cytokine induction in mice by the immunomodulator imiquimod. Reiter, M.J., Testerman, T.L., Miller, R.L., Weeks, C.E., Tomai, M.A. J. Leukoc. Biol. (1994) [Pubmed]
  22. Histamine augments interleukin-2 production and the activation of cytotoxic T lymphocytes. Dröge, W., Schmidt, H., Nick, S., Sonsky, B. Immunopharmacology (1986) [Pubmed]
  23. Regulation of Con A-dependent cytokine production from CD4+ and CD8+ T lymphocytes by autosecretion of histamine. Sonobe, Y., Nakane, H., Watanabe, T., Nakano, K. Inflamm. Res. (2004) [Pubmed]
  24. Persulfide sulfur is a growth factor for cells defective in sulfur metabolism. Toohey, J.I. Biochem. Cell Biol. (1986) [Pubmed]
  25. Enhancement of mitogen-induced lymphocyte proliferation by some inhibitors of alkaline phosphatase and diamine oxidase. Metaye, T., Baudry, M., Lalegerie, P. Int. J. Immunopharmacol. (1989) [Pubmed]
  26. In vivo and in vitro lipidation of recombinant immunogens for direct iscom incorporation. Andersson, C., Wikman, M., Lövgren-Bengtsson, K., Lundén, A., Ståhl, S. J. Immunol. Methods (2001) [Pubmed]
  27. Uncoupling protein 2 involved in protection of glucagon-like peptide 2 in small intestine with ischemia-reperfusion injury in mice. Guan, L., Gong, D., Tian, N., Zou, Y. Dig. Dis. Sci. (2005) [Pubmed]
  28. Studies on the effect of polyamines and their products on Ehrlich ascites tumours. Mondovì, B., Gerosa, P., Cavaliere, R. Agents Actions (1982) [Pubmed]
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