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Gene Review

Aoc1  -  amine oxidase, copper containing 1

Rattus norvegicus

Synonyms: Abp, Abp1, Amiloride-binding protein 1, Amine oxidase copper domain-containing protein 1, DAO, ...
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Disease relevance of Abp1

  • Effect of intestinal ischemia on diamine oxidase activity in rat intestinal tissue and blood [1].
  • Diamine oxidase activity in regenerating rat liver and in 4-dimethylaminoazobenzene-induced and Yoshida AH 130 hepatomas [2].
  • A large increase in diamine oxidase activity, as compared to the values of normal liver, was also observed in 4-dimethylaminoazobenzene and Yoshida ascites hepatomas [2].
  • While weight loss should be taken into consideration when interpreting cause and effect relationships in streptozotocin-treated animals, epididymal ABP levels appear to be well correlated with the altered metabolic state characteristic of diabetes [3].
  • 4. We propose that by 3-5 weeks of chronic hypoxia renal function was normalized, principally because arterial O2 content was normalized by the increase in haematocrit and because ABP and renal haemodynamics were normalized: acute hypoxia in N rats produces a fall in ABP [4].

High impact information on Abp1


Chemical compound and disease context of Abp1


Biological context of Abp1


Anatomical context of Abp1


Associations of Abp1 with chemical compounds

  • The distribution of rat ABP is not as would be predicted for an aldosterone-induced gene and is thus unlikely to be a component of the amiloride-sensitive electrogenic sodium channel [15].
  • These results suggest that aldehyde-metabolizing enzymes present in homogenate may interfere with the amount of delta 1-pyrroline formation and that the use of acetaldehyde may give better information on tissue diamine oxidase activity [2].
  • Acetaldehyde did not modify the activity of a preparation of hog kidney diamine oxidase, while chloral hydrate and disulfiram, respectively, enhanced and depressed the activity of this enzyme [2].
  • In addition, none of the three NK cell lines were found to contain histaminase-sensitive histamine [20].
  • We tested the effect of 2-amino-5-bromo-6 phenyl-4 pyrimidinol (ABPP), an interferon (IFN) inducer, on NK cell cytotoxicity in various tissues of athymic and euthymic rats [21].

Other interactions of Abp1


Analytical, diagnostic and therapeutic context of Abp1

  • We investigated the role of PDZ proteins (GRIP, ABP, and PICK1) interacting with the C-terminal GluR2 by infusing a ct-GluR2 peptide ("pep2-SVKI") into CA1 pyramidal neurons in hippocampal slices using whole-cell recordings [24].
  • Diamine oxidase activity, which was very low in normal liver, increased rapidly in regenerating liver and reached maximum values between 16 and 48 hr after hepatectomy [2].
  • One (ABP kinase peak 1) coelutes with the peak of RSK2 as judged by immunoblotting and S6 peptide kinase assays [25].
  • The liver activities of histamine-metabolizing enzymes, histamine-N-methyltransferase and histaminase, decreased to 1/3.4 and 1/6.0 times those of the nontreated group, respectively, 12 weeks after treatment with CCl4, whereas blood histaminase increased about 9.2 times [26].
  • The binding of iodinated ABP to the receptor was similar to that of photoaffinity-labelled ABP in gel filtration [27].


  1. Effect of intestinal ischemia on diamine oxidase activity in rat intestinal tissue and blood. Wollin, A., Navert, H., Bounous, G. Gastroenterology (1981) [Pubmed]
  2. Diamine oxidase activity in regenerating rat liver and in 4-dimethylaminoazobenzene-induced and Yoshida AH 130 hepatomas. Sessa, A., Desiderio, M.A., Baizini, M., Perin, A. Cancer Res. (1981) [Pubmed]
  3. Sertoli cell function in diabetic, insulin-treated diabetic, and semi-starved rats. Hutson, J.C., Stocco, D.M., Campbell, G.T., Wagoner, J. Diabetes (1983) [Pubmed]
  4. The effects of chronic hypoxia on renal function in the rat. Neylon, M., Marshall, J.M., Johns, E.J. J. Physiol. (Lond.) (1997) [Pubmed]
  5. Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses. Liu, S.J., Cull-Candy, S.G. Nat. Neurosci. (2005) [Pubmed]
  6. Agmatine, a bioactive metabolite of arginine. Production, degradation, and functional effects in the kidney of the rat. Lortie, M.J., Novotny, W.F., Peterson, O.W., Vallon, V., Malvey, K., Mendonca, M., Satriano, J., Insel, P., Thomson, S.C., Blantz, R.C. J. Clin. Invest. (1996) [Pubmed]
  7. Clostridium difficile toxin A-induced microvascular dysfunction. Role of histamine. Kurose, I., Pothoulakis, C., LaMont, J.T., Anderson, D.C., Paulson, J.C., Miyasaka, M., Wolf, R., Granger, D.N. J. Clin. Invest. (1994) [Pubmed]
  8. Binding of diamine oxidase activity to rat and guinea pig microvascular endothelial cells. Comparisons with lipoprotein lipase binding. Robinson-White, A., Baylin, S.B., Olivecrona, T., Beaven, M.A. J. Clin. Invest. (1985) [Pubmed]
  9. Suppression of diamine oxidase activity enhances postresection ileal proliferation in the rat. Erdman, S.H., Park, J.H., Thompson, J.S., Grandjean, C.J., Hart, M.H., Vanderhoof, J.A. Gastroenterology (1989) [Pubmed]
  10. Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia. Skinner, M.R., Marshall, J.M. J. Physiol. (Lond.) (1996) [Pubmed]
  11. Advantages of raloxifene over alendronate or estrogen on nonreproductive and reproductive tissues in the long-term dosing of ovariectomized rats. Sato, M., Bryant, H.U., Iversen, P., Helterbrand, J., Smietana, F., Bemis, K., Higgs, R., Turner, C.H., Owan, I., Takano, Y., Burr, D.B. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  12. Effect of acute ethanol administration on diamine oxidase activity in the upper gastrointestinal tract of rat. Sessa, A., Desiderio, A., Perin, A. Alcohol. Clin. Exp. Res. (1984) [Pubmed]
  13. Roles of histamine and diamine oxidase in mucosa of rat small intestine after ischemia-reperfusion. Fujiskai, J., Fujimoto, K., Oohara, A., Sakata, T., Hirano, M., Ohyama, T., Iwakiri, R., Yamaguchi, M. Dig. Dis. Sci. (1993) [Pubmed]
  14. Diamine oxidase activity in rat brain carcinogenesis and in gliomas. Sessa, A., Broglia, E., Terreni, M.R., Perin, A. Cancer Lett. (1993) [Pubmed]
  15. Isolation of a rat amiloride-binding protein cDNA clone: tissue distribution and regulation of expression. Verity, K., Fuller, P.J. Am. J. Physiol. (1994) [Pubmed]
  16. Influences on the cardiovascular response to graded levels of systemic hypoxia of the accompanying hypocapnia in the rat. Marshall, J.M., Metcalfe, J.D. J. Physiol. (Lond.) (1989) [Pubmed]
  17. A study on rats of the effects of chronic hypoxia from birth on respiratory and cardiovascular responses evoked by acute hypoxia. Thomas, T., Marshall, J.M. J. Physiol. (Lond.) (1995) [Pubmed]
  18. Catabolism of histamine in the isolated glomeruli and tubules of the rat kidney. Abboud, H.E. Kidney Int. (1983) [Pubmed]
  19. Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family. Qualmann, B., Boeckers, T.M., Jeromin, M., Gundelfinger, E.D., Kessels, M.M. J. Neurosci. (2004) [Pubmed]
  20. Expression of IgE receptors and histamine in cloned natural killer cell lines. Rosenthal, K.L., Ishizaka, T., Befus, D., Dennert, G., Hengartner, H., Bienenstock, J. J. Immunol. (1984) [Pubmed]
  21. Stimulation of natural killer cells in two random-bred strains of athymic rats by interferon-inducing pyrimidinone. Lotzová, E., Savary, C.A., Khan, A., Stringfellow, D.A. J. Immunol. (1984) [Pubmed]
  22. Ornithine decarboxylase in rat small intestine: stimulation with food or insulin. Maudsley, D.V., Leif, J., Kobayashi, Y. Am. J. Physiol. (1976) [Pubmed]
  23. Ornithine decarboxylase, transglutaminase, diamine oxidase and total diamines and polyamines in maternal liver and kidney throughout rat pregnancy. Piacentini, M., Sartori, C., Beninati, S., Bargagli, A.M., Cerù-Argento, M.P. Biochem. J. (1986) [Pubmed]
  24. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Daw, M.I., Chittajallu, R., Bortolotto, Z.A., Dev, K.K., Duprat, F., Henley, J.M., Collingridge, G.L., Isaac, J.T. Neuron (2000) [Pubmed]
  25. Phosphorylation of actin-binding protein 280 by growth factors is mediated by p90 ribosomal protein S6 kinase. Ohta, Y., Hartwig, J.H. J. Biol. Chem. (1996) [Pubmed]
  26. Change of hepatic histamine content during hepatic fibrosis. Umezu, K., Yuasa, S., Sudoh, A. Biochem. Pharmacol. (1985) [Pubmed]
  27. Evidence that androgen-binding protein endocytosis in vitro is receptor mediated in principal cells of the rat epididymis. Guéant, J.L., Fremont, S., Felden, F., Nicolas, J.P., Gerard, A., Leheup, B., Gerard, H., Grignon, G. J. Mol. Endocrinol. (1991) [Pubmed]
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