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Gene Review

RELB  -  v-rel avian reticuloendotheliosis viral...

Homo sapiens

Synonyms: I-REL, I-Rel, IREL, REL-B, Transcription factor RelB
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High impact information on RELB

  • Transfection experiments demonstrate that I-Rel suppresses NF-kappa B-induced transcription, probably through its association with p50 [1].
  • The transcription factor RelB is required for proper development and function of dendritic cells (DCs), and its expression is upregulated early during differentiation from a variety of progenitors [2].
  • Here we demonstrate that the nuclear factor-kappaB (NF-kappaB) transcription factor RelB regulates the generation of monocytic CD14(+)CD11b(+) precursors of interstitial DCs from human hematopoietic progenitors [3].
  • On the other hand, the I-Rel protein, the presumed human homolog of RelB, was proposed to be an inhibitor whose presence in dimeric complexes interfered with their kappa B binding and therefore interfered also with transactivation [4].
  • DETA-NONOate evoked a wave of expression changes (maximum at 4 h), with a remarkable downregulation of the transcription factors MSX1, RELB, and Egr-1 [5].

Biological context of RELB

  • We demonstrate that human RelB (I-Rel) forms with p50 and p52 (p50B) kappa B-binding heterodimeric complexes which potently transactivate kappa B-dependent constructs in transfection studies [4].
  • A critical role of NF-kappaB in promoting cell survival in IFN-alpha-resistant cells is indicated by the upregulation of RELB and LTB [6].

Other interactions of RELB

  • A relatively high number of genes involved in innate and inflammatory host immune responses, including interleukin-8, interleukin-6, NF-kappaB(2), RELB and fos, were induced [7].
  • Triggering of this receptor induces a unique signalling cascade leading to the activation of the transcription factor RelB through activation of NF-kappa B inducing kinase [8].


  1. I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity. Ruben, S.M., Klement, J.F., Coleman, T.A., Maher, M., Chen, C.H., Rosen, C.A. Genes Dev. (1992) [Pubmed]
  2. Regulation of RelB expression during the initiation of dendritic cell differentiation. Cejas, P.J., Carlson, L.M., Kolonias, D., Zhang, J., Lindner, I., Billadeau, D.D., Boise, L.H., Lee, K.P. Mol. Cell. Biol. (2005) [Pubmed]
  3. RelB regulates human dendritic cell subset development by promoting monocyte intermediates. Platzer, B., Jörgl, A., Taschner, S., Höcher, B., Strobl, H. Blood (2004) [Pubmed]
  4. Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins. Bours, V., Azarenko, V., Dejardin, E., Siebenlist, U. Oncogene (1994) [Pubmed]
  5. Nitric oxide donor induces temporal and dose-dependent reduction of gene expression in human endothelial cells. Braam, B., de Roos, R., Dijk, A., Boer, P., Post, J.A., Kemmeren, P.P., Holstege, F.C., Bluysen, H.A., Koomans, H.A. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  6. Transcriptional response of T cells to IFN-alpha: changes induced in IFN-alpha-sensitive and resistant cutaneous T cell lymphoma. Tracey, L., Spiteri, I., Ortiz, P., Lawler, M., Piris, M.A., Villuendas, R. J. Interferon Cytokine Res. (2004) [Pubmed]
  7. Gene expression changes induced by a recombinant E1-/E3- adenovirus type 5 vector in human mammary epithelial cells. Scibetta, A.G., Copier, J., Barrett, A., Chaplin, T., Taylor-Papadimitriou, J. Intervirology (2005) [Pubmed]
  8. Lymphotoxin alpha 1 beta 2: a critical mediator in V alpha 14i NKT cell differentiation. Franki, A.S., Van Beneden, K., Dewint, P., Meeus, I., Veys, E., Deforce, D., Elewaut, D. Mol. Immunol. (2005) [Pubmed]
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