Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

BCL2L2 - BCL2-like 2

Homo sapiens

Synonyms: BCL-W, BCL2-L-2, BCLW, KIAA0271, PPP1R51

Tran, N.L. et al., Yasui, K. et al., Ross, A.J. et al., Ogawa, Y. et al.

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Disease relevance of BCL2L2

Down-regulation of BCL2L2 with an antisense oligonucleotide sensitized a VP-16 resistant ovarian-cancer cell line (SKOV3/VP) to VP-16 [1].
Our results suggest that NFkappaB-mediated up-regulation of BCL-XL and BCL-W expression in glioma cells increases cellular resistance to cytotoxic therapy-induced apoptosis [2].
We propose that the Fn14 protein functions, in part, through the NFkappaB signaling pathway to up-regulate BCL-XL and BCL-W expression to foster malignant glioblastoma cell survival [2].

High impact information on BCL2L2

Expression of Bclw in the testis appears to be restricted to elongating spermatids and Sertoli cells [3].
Additionally small interfering RNA-mediated depletion of either BCL-XL or BCL-W antagonized the TWEAK protective effect on glioma cells [2].
An apoptosis regulator bclw showed a remarkable decrease in irradiated T cells [4].

References

Alteration in copy numbers of genes as a mechanism for acquired drug resistance. Yasui, K., Mihara, S., Zhao, C., Okamoto, H., Saito-Ohara, F., Tomida, A., Funato, T., Yokomizo, A., Naito, S., Imoto, I., Tsuruo, T., Inazawa, J. Cancer Res. (2004) [Pubmed]
The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression. Tran, N.L., McDonough, W.S., Savitch, B.A., Sawyer, T.F., Winkles, J.A., Berens, M.E. J. Biol. Chem. (2005) [Pubmed]
Testicular degeneration in Bclw-deficient mice. Ross, A.J., Waymire, K.G., Moss, J.E., Parlow, A.F., Skinner, M.K., Russell, L.D., MacGregor, G.R. Nat. Genet. (1998) [Pubmed]
Radiation-induced apoptosis of human peripheral T cells: analyses with cDNA expression arrays and mitochondrial membrane potential assay. Ogawa, Y., Nishioka, A., Kobayashi, T., Kariya, S., Hamasato, S., Saibara, T., Seguchi, H., Yoshida, S. Int. J. Mol. Med. (2001) [Pubmed]

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