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Gene Review

Bcl2l2  -  BCL2-like 2

Mus musculus

Synonyms: AW048834, Apoptosis regulator Bcl-W, Bcl-2-like protein 2, Bcl-w, Bcl2-L-2, ...
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Disease relevance of Bcl2l2


High impact information on Bcl2l2


Biological context of Bcl2l2


Anatomical context of Bcl2l2

  • Therefore, Bclw-independent pathways promote the survival of undifferentiated, mitotic Sertoli cells [6].
  • RESULTS: When compared with Bcl-w, the most significant expression changes were observed with Bax and took place within crypt enterocytes [2].
  • Reciprocal developmental changes in the roles of Bcl-w and Bcl-x(L) in regulating sensory neuron survival [4].
  • There was a marked increased in Bcl-w mRNA and Bcl-w immunoreactive neurons and a decrease in Bcl-x(L) mRNA and Bcl-x(L) immunoreactive neurons in the trigeminal and nodose ganglia over this period of development [4].
  • In the adult rat testis, both Bcl-w mRNA and protein in Sertoli cells displayed a stage-specific expression pattern [8].

Associations of Bcl2l2 with chemical compounds


Physical interactions of Bcl2l2

  • Bcl-xL and Bcl-w specifically interact with PP1alpha and Bad [9].

Regulatory relationships of Bcl2l2


Other interactions of Bcl2l2


Analytical, diagnostic and therapeutic context of Bcl2l2


  1. Bcl-w protects hippocampus during experimental status epilepticus. Murphy, B., Dunleavy, M., Shinoda, S., Schindler, C., Meller, R., Bellver-Estelles, C., Hatazaki, S., Dicker, P., Yamamoto, A., Koegel, I., Chu, X., Wang, W., Xiong, Z., Prehn, J., Simon, R., Henshall, D. Am. J. Pathol. (2007) [Pubmed]
  2. Epidermal growth factor receptor signaling regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice. Bernal, N.P., Stehr, W., Coyle, R., Erwin, C.R., Warner, B.W. Gastroenterology (2006) [Pubmed]
  3. Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant. Print, C.G., Loveland, K.L., Gibson, L., Meehan, T., Stylianou, A., Wreford, N., de Kretser, D., Metcalf, D., Köntgen, F., Adams, J.M., Cory, S. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  4. Reciprocal developmental changes in the roles of Bcl-w and Bcl-x(L) in regulating sensory neuron survival. Middleton, G., Wyatt, S., Ninkina, N., Davies, A.M. Development (2001) [Pubmed]
  5. bcl-w, a novel member of the bcl-2 family, promotes cell survival. Gibson, L., Holmgreen, S.P., Huang, D.C., Bernard, O., Copeland, N.G., Jenkins, N.A., Sutherland, G.R., Baker, E., Adams, J.M., Cory, S. Oncogene (1996) [Pubmed]
  6. BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity. Ross, A.J., Amy, S.P., Mahar, P.L., Lindsten, T., Knudson, C.M., Thompson, C.B., Korsmeyer, S.J., MacGregor, G.R. Dev. Biol. (2001) [Pubmed]
  7. Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland. Metcalfe, A.D., Gilmore, A., Klinowska, T., Oliver, J., Valentijn, A.J., Brown, R., Ross, A., MacGregor, G., Hickman, J.A., Streuli, C.H. J. Cell. Sci. (1999) [Pubmed]
  8. Bcl-w forms complexes with Bax and Bak, and elevated ratios of Bax/Bcl-w and Bak/Bcl-w correspond to spermatogonial and spermatocyte apoptosis in the testis. Yan, W., Samson, M., Jégou, B., Toppari, J. Mol. Endocrinol. (2000) [Pubmed]
  9. The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad. Ayllón, V., Cayla, X., García, A., Fleischer, A., Rebollo, A. Eur. J. Immunol. (2002) [Pubmed]
  10. C2-ceramide as a cell death inducer in HC11 mouse mammary epithelial cells. Kim, S.H., Kim, S.C., Kho, Y.J., Kwak, S.W., Lee, H.G., You, S.K., Woo, J.H., Choi, Y.J. Cancer Lett. (2004) [Pubmed]
  11. Effect of iodide on Fas, Fas-ligand and Bcl-w mRNA expression in thyroid of NOD mice pretreated with methimazole. Boechat, L.H., Vilella, C.A., Zollner, R.L. Braz. J. Med. Biol. Res. (2002) [Pubmed]
  12. Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members. Holmgreen, S.P., Huang, D.C., Adams, J.M., Cory, S. Cell Death Differ. (1999) [Pubmed]
  13. Total parenteral nutrition-induced apoptosis in mouse intestinal epithelium: regulation by the Bcl-2 protein family. Wildhaber, B.E., Lynn, K.N., Yang, H., Teitelbaum, D.H. Pediatr. Surg. Int. (2002) [Pubmed]
  14. Spermatogenesis in Bclw-deficient mice. Russell, L.D., Warren, J., Debeljuk, L., Richardson, L.L., Mahar, P.L., Waymire, K.G., Amy, S.P., Ross, A.J., MacGregor, G.R. Biol. Reprod. (2001) [Pubmed]
  15. Mouse keratinocytes express c98, a novel gene homologous to bcl-2, that is stimulated by insulin-like growth factor 1 and prevents dexamethasone-induced apoptosis. Su, H.Y., Cheng, W.T., Chen, S.C., Lin, C.T., Lien, Y.Y., Liu, H.J., Gilmour, R.S. Biochim. Biophys. Acta (2004) [Pubmed]
  16. Tissue expression and subcellular localization of the pro-survival molecule Bcl-w. O'Reilly, L.A., Print, C., Hausmann, G., Moriishi, K., Cory, S., Huang, D.C., Strasser, A. Cell Death Differ. (2001) [Pubmed]
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