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Gene Review

GAD2  -  glutamate decarboxylase 2 (pancreatic...

Macaca mulatta

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High impact information on GAD2

  • Both the GAD67 and the GAD65 antisense D-oligos induced a large and prompt increase in LHRH release, whereas the scrambled D-oligos did not induce any significant effect [1].
  • No significant change in GAD65 concentration was detected in the microdissected dentate gyrus despite the induction of GAD65-LI [2].
  • Regional distribution of glutamic acid decarboxylase (GAD65 and GAD67) mRNA in the hypothalamus of male rhesus macaques before and after puberty [3].

Anatomical context of GAD2


Other interactions of GAD2

  • The GAD67 or GAD65 antisense D-oligos or scrambled D-oligos were infused directly into the stalk-median eminence [1].

Analytical, diagnostic and therapeutic context of GAD2

  • Bilateral orchidectomy produced a significant increase in GnRH mRNA levels that was restricted to the mediobasal hypothalamus and that was associated with a significant decrease in POMC, GAD65 and GAD67 mRNA levels in this region of the hypothalamus [6].


  1. Role of glutamic acid decarboxylase in the prepubertal inhibition of the luteinizing hormone releasing hormone release in female rhesus monkeys. Mitsushima, D., Marzban, F., Luchansky, L.L., Burich, A.J., Keen, K.L., Durning, M., Golos, T.G., Terasawa, E. J. Neurosci. (1996) [Pubmed]
  2. Basal expression and induction of glutamate decarboxylase and GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus. Sloviter, R.S., Dichter, M.A., Rachinsky, T.L., Dean, E., Goodman, J.H., Sollas, A.L., Martin, D.L. J. Comp. Neurol. (1996) [Pubmed]
  3. Regional distribution of glutamic acid decarboxylase (GAD65 and GAD67) mRNA in the hypothalamus of male rhesus macaques before and after puberty. Urbanski, H.F., Rodrigues, S.M., Garyfallou, V.T., Kohama, S.G. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  4. Distribution of GABAergic cells and fibers in the hippocampal formation of the macaque monkey: an immunohistochemical and in situ hybridization study. Jongen-Rêlo, A.L., Pitkänen, A., Amaral, D.G. J. Comp. Neurol. (1999) [Pubmed]
  5. L-DOPA regulates glutamate decarboxylases mRNA levels in MPTP-treated monkeys. Soghomonian, J.J., Pedneault, S., Blanchet, P.J., Goulet, M., Di Paolo, T., Bédard, P.J. Brain Res. Mol. Brain Res. (1996) [Pubmed]
  6. Effects of orchidectomy on levels of the mRNAs encoding gonadotropin-releasing hormone and other hypothalamic peptides in the adult male rhesus monkey (Macaca mulatta). El Majdoubi, M., Ramaswamy, S., Sahu, A., Plant, T.M. J. Neuroendocrinol. (2000) [Pubmed]
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