Gene Review:
GAD2 - glutamate decarboxylase 2 (pancreatic...
Homo sapiens
Synonyms:
65 kDa glutamic acid decarboxylase, GAD-65, GAD65, Glutamate decarboxylase 2, Glutamate decarboxylase 65 kDa isoform
- GAD2 on chromosome 10p12 is a candidate gene for human obesity. Boutin, P., Dina, C., Vasseur, F., Dubois, S., Corset, L., Séron, K., Bekris, L., Cabellon, J., Neve, B., Vasseur-Delannoy, V., Chikri, M., Charles, M.A., Clement, K., Lernmark, A., Froguel, P. PLoS Biol. (2003)
- Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11. Fenalti, G., Hampe, C.S., O'connor, K., Banga, J.P., Mackay, I.R., Rowley, M.J., El-Kabbani, O. Mol. Immunol. (2007)
- Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression. Velloso, L.A., Kämpe, O., Hallberg, A., Christmanson, L., Betsholtz, C., Karlsson, F.A. J. Clin. Invest. (1993)
- Receptors and sites of synthesis and storage of gamma-aminobutyric acid in human pituitary glands and in growth hormone adenomas. End, K., Gamel-Didelon, K., Jung, H., Tolnay, M., Lüdecke, D., Gratzl, M., Mayerhofer, A. Am. J. Clin. Pathol. (2005)
- Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children? Meyre, D., Boutin, P., Tounian, A., Deweirder, M., Aout, M., Jouret, B., Heude, B., Weill, J., Tauber, M., Tounian, P., Froguel, P. J. Clin. Endocrinol. Metab. (2005)
- A high prevalence of organ-specific autoimmunity in patients with bipolar disorder. Padmos, R.C., Bekris, L., Knijff, E.M., Tiemeier, H., Kupka, R.W., Cohen, D., Nolen, W.A., Lernmark, A., Drexhage, H.A. Biol. Psychiatry (2004)
- Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB1*0401-positive individuals. Reijonen, H., Elliott, J.F., van Endert, P., Nepom, G. J. Immunol. (1999)
- GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum. Fatemi, S.H., Hossein Fatemi, S., Stary, J.M., Earle, J.A., Araghi-Niknam, M., Eagan, E. Schizophr. Res. (2005)
- High-dose intravenous immune globulin for stiff-person syndrome. Dalakas, M.C., Fujii, M., Li, M., Lutfi, B., Kyhos, J., McElroy, B. N. Engl. J. Med. (2001)
- Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus. Kim, J., Namchuk, M., Bugawan, T., Fu, Q., Jaffe, M., Shi, Y., Aanstoot, H.J., Turck, C.W., Erlich, H., Lennon, V., Baekkeskov, S. J. Exp. Med. (1994)
- Improved in planta expression of the human islet autoantigen glutamic acid decarboxylase (GAD65). Avesani, L., Falorni, A., Tornielli, G.B., Marusic, C., Porceddu, A., Polverari, A., Faleri, C., Calcinaro, F., Pezzotti, M. Transgenic Res. (2003)
- Time-resolved fluorometric assay for detection of autoantibodies to glutamic acid decarboxylase (GAD65). Ankelo, M., Westerlund-Karlsson, A., Ilonen, J., Knip, M., Savola, K., Kankaanpää, P., Meriö, L., Siitari, H., Hinkkanen, A. Clin. Chem. (2003)
- Intradermal skin test with diabetes specific antigens in patients with type 1 diabetes. Crinò, A., Cavallo, M.G., Corbi, S., Mesturino, C.A., Ferrazzoli, F., Coppolino, G., Bizzarri, C., Cervoni, M., Monetini, L., Pozzilli, P. Clin. Exp. Immunol. (2001)
- Tyrosine phosphatase-like protein (IA-2) and glutamic acid decarboxylase (GAD65) autoantibodies: a study of Chinese patients with diabetes mellitus. Ng, W.Y., Lee, Y.S., Todd, A.L., Lui, K.F., Loke, K.Y., Thai, A.C. Autoimmunity (2002)
- Lack of association of glutamate decarboxylase 2 gene polymorphisms with severe obesity in utah. Hunt, S.C., Xin, Y., Wu, L.L., Hopkins, P.N., Adams, T.D. Obesity (Silver Spring, Md.) (2006)
- A comprehensive, statistically powered analysis of GAD2 in type 1 diabetes. Johnson, G.C., Payne, F., Nutland, S., Stevens, H., Tuomilehto-Wolf, E., Tuomilehto, J., Todd, J.A. Diabetes (2002)
- Glutamate decarboxylase is not genetically linked to pyridoxine-dependent seizures. Battaglioli, G., Rosen, D.R., Gospe, S.M., Martin, D.L. Neurology (2000)
- Mapping of glutamic acid decarboxylase (GAD) genes. Edelhoff, S., Grubin, C.E., Karlsen, A.E., Alder, D.A., Foster, D., Disteche, C.M., Lernmark, A. Genomics (1993)
- Glutamate decarboxylase genes and alcoholism in han taiwanese men. Loh, e.l.-.W., Lane, H.Y., Chen, C.H., Chang, P.S., Ku, L.W., Wang, K.H., Cheng, A.T. Alcohol. Clin. Exp. Res. (2006)
- Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. Karlsen, A.E., Hagopian, W.A., Grubin, C.E., Dube, S., Disteche, C.M., Adler, D.A., Bärmeier, H., Mathewes, S., Grant, F.J., Foster, D. Proc. Natl. Acad. Sci. U.S.A. (1991)
- A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65. Kanaani, J., el-Husseini, A.e.l.-.D., Aguilera-Moreno, A., Diacovo, J.M., Bredt, D.S., Baekkeskov, S. J. Cell Biol. (2002)
- Structural and functional analysis of cysteine residues in human glutamate decarboxylase 65 (GAD65) and GAD67. Wei, J., Wu, J.Y. J. Neurochem. (2005)
- Gibberellins regulate the abundance of RNAs with sequence similarity to proteinase inhibitors, dioxygenases and dehydrogenases. Jacobsen, S.E., Olszewski, N.E. Planta (1996)
- Conformation-dependent GAD65 autoantibodies in diabetes. Luo, D., Gilliam, L.K., Greenbaum, C., Bekris, L., Hampe, C.S., Daniels, T., Richter, W., Marcovina, S.M., Rolandsson, O., Landin-Olsson, M., Kockum, I., Lernmark, A. Diabetologia (2004)
- Characterisation of an autoreactive conformational epitope on GAD65 recognised by the human monoclonal antibody b78 using a combination of phage display, in vitro mutagenesis and molecular modelling. O'Connor, K.H., Banga, J.P., Darmanin, C., El-Kabbani, O., Mackay, I.R., Rowley, M.J. J. Autoimmun. (2006)
- Comparison of the prevalence of glutamic acid decarboxylase (GAD65) and gliadin antibodies (AGA) in a randomly selected adult estonian population. Uibo, R., Sullivan, E.P., Uibo, O., Lernmark, A., Salur, L., Kivik, T., Mandel, M. Horm. Metab. Res. (2001)
- Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylase. Dirkx, R., Thomas, A., Li, L., Lernmark, A., Sherwin, R.S., De Camilli, P., Solimena, M. J. Biol. Chem. (1995)
- GAD67 and GAD65 mRNA and protein expression in cerebrocortical regions of elderly patients with schizophrenia. Dracheva, S., Elhakem, S.L., McGurk, S.R., Davis, K.L., Haroutunian, V. J. Neurosci. Res. (2004)
- Neurochemical characterization of dopaminergic neurons in human striatum. Cossette, M., Lévesque, D., Parent, A. Parkinsonism Relat. Disord. (2005)
- Glutamic acid decarboxylase (GAD65) autoantibodies in prediction of beta-cell function and remission in recent-onset IDDM after cyclosporin treatment. The Canadian-European Randomized Control Trial Group. Petersen, J.S., Dyrberg, T., Karlsen, A.E., Mølvig, J., Michelsen, B., Nerup, J., Mandrup-Poulsen, T. Diabetes (1994)
- Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins. Huang, K., Yanai, A., Kang, R., Arstikaitis, P., Singaraja, R.R., Metzler, M., Mullard, A., Haigh, B., Gauthier-Campbell, C., Gutekunst, C.A., Hayden, M.R., El-Husseini, A. Neuron (2004)
- A gene for pyridoxine-dependent epilepsy maps to chromosome 5q31. Cormier-Daire, V., Dagoneau, N., Nabbout, R., Burglen, L., Penet, C., Soufflet, C., Desguerre, I., Munnich, A., Dulac, O. Am. J. Hum. Genet. (2000)
- Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cells. Greening, J.E., Tree, T.I., Kotowicz, K.T., van Halteren, A.G., Roep, B.O., Klein, N.J., Peakman, M. Diabetes (2003)
- T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading. Ott, P.A., Dittrich, M.T., Herzog, B.A., Guerkov, R., Gottlieb, P.A., Putnam, A.L., Durinovic-Bello, I., Boehm, B.O., Tary-Lehmann, M., Lehmann, P.V. J. Clin. Immunol. (2004)