Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ACE - angiotensin I converting enzyme (peptidyl...

Bos taurus

This record was replaced with 509484.

Somlev, B. et al., Kumakura, S. et al., Ryan, U.S. et al., Ryan, U.S. et al.

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High impact information on LOC614289

3 Captopril (an inhibitor of kininase II) elevated both the bradykinin level in the inflammatory pouch fluid and vascular permeability, while DL-2-mercaptomethyl-3- guanidinoethylthiopropanoic acid (an inhibitor of kininase I) had no effect [1].
In this study we examined the influence of 2 kininase II inhibitors (captopril and enalapril maleate) on bradykinin-induced bovine sperm motility [2].
Effect of kininase II inhibitors on bradykinin-stimulated bovine sperm motility [2].
It has been found that the enzyme kininase II present in the seminal plasma inactivates the kinins produced by the kallikreins, thus blocking their beneficial effects on the motility of post-ejaculated mammalian spermatozoa [2].
Endothelial cells are a major source of kininase enzymes including kininase II [3].

Anatomical context of LOC614289

Kininase II is situated along the plasma membrane, not as an ecto-enzyme but as an enzyme synthesized by the endothelial cells themselves [3].

Associations of LOC614289 with chemical compounds

Kininase II (angiotensin converting enzyme) and endothelial cells in culture [4].

References

Role of bradykinin in the vascular permeability response induced by carrageenin in rats. Kumakura, S., Kamo, I., Tsurufuji, S. Br. J. Pharmacol. (1988) [Pubmed]
Effect of kininase II inhibitors on bradykinin-stimulated bovine sperm motility. Somlev, B., Subev, M. Theriogenology (1998) [Pubmed]
Endothelial cells and components of the kallikrein-kinin system. Ryan, U.S., Ryan, J.W., Habliston, D.L., Pena, G.A. Adv. Exp. Med. Biol. (1979) [Pubmed]
Kininase II (angiotensin converting enzyme) and endothelial cells in culture. Ryan, U.S., Ryan, J.W., Chiu, A. Adv. Exp. Med. Biol. (1976) [Pubmed]

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