The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

NPY  -  neuropeptide Y

Bos taurus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of NPY

 

High impact information on NPY

  • Whereas complete reconstitution of NPY effects could be obtained with alpha o, no single alpha subunit produced complete reconstitution of BK [3].
  • Seminalplasmin: recent evolution of another member of the neuropeptide Y gene family [5].
  • The adrenal gland is involved in the regulation of vascular tone by secretion of vasoactive agents such as catecholamines, neuropeptide Y, or endogenous ouabain [6].
  • In contrast, vesicles immunoisolated with synaptophysin beads did not contain detectable levels of NPY [7].
  • Furthermore, the vesicles immunoisolated with synaptotagmin beads contained significant amounts of neuropeptide Y (NPY) [7].
 

Chemical compound and disease context of NPY

 

Biological context of NPY

 

Anatomical context of NPY

 

Associations of NPY with chemical compounds

 

Physical interactions of NPY

  • Expression of LCR1 in mammalian cells revealed saturable and specific high affinity binding for 125I-NPY but not for any of the other ligands tested [18].
 

Regulatory relationships of NPY

  • These results indicate that NPY has the ability to inhibit the catalytic action of DBH [19].
  • In conclusion, TCV injection of NPY suppressed pituitary secretion of LH and simultaneously tended to increase pituitary secretion of GH [20].
  • Neuropeptide Y inhibits chromaffin cell nicotinic receptor-stimulated tyrosine hydroxylase activity through a receptor-linked G protein-mediated process [2].
 

Other interactions of NPY

  • NPY, Y1RL, and PYY displayed a concentration that inhibits the specific binding by 50% IC50 (nM) values of 4.06 +/- 1.66 (n = 4), 2.94 +/- 0.75 (n = 5), and 18.36 +/- 10.36 (n = 3), respectively [21].
  • Presynaptic inhibitory effects of the peptides NPY, PYY and PP on nicotinic EPSPs in guinea-pig gastric myenteric neurones [22].
  • Here we compare the exocytic release of fluorescently labelled neuropeptide Y (NPY) and tissue plasminogen activator from single granules [23].
  • In contrast to NPY, VIP was first found in the cortex [13].
  • NPY (20-80 pmol/ml) produced a dose-dependent depression of NE formation catalysed by the purified bovine adrenal DBH [19].
 

Analytical, diagnostic and therapeutic context of NPY

References

  1. Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. Loetscher, M., Geiser, T., O'Reilly, T., Zwahlen, R., Baggiolini, M., Moser, B. J. Biol. Chem. (1994) [Pubmed]
  2. Neuropeptide Y inhibits chromaffin cell nicotinic receptor-stimulated tyrosine hydroxylase activity through a receptor-linked G protein-mediated process. Zheng, J., Zhang, P., Hexum, T.D. Mol. Pharmacol. (1997) [Pubmed]
  3. Differential G protein-mediated coupling of neurotransmitter receptors to Ca2+ channels in rat dorsal root ganglion neurons in vitro. Ewald, D.A., Pang, I.H., Sternweis, P.C., Miller, R.J. Neuron (1989) [Pubmed]
  4. Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen. Federsppiel, B., Melhado, I.G., Duncan, A.M., Delaney, A., Schappert, K., Clark-Lewis, I., Jirik, F.R. Genomics (1993) [Pubmed]
  5. Seminalplasmin: recent evolution of another member of the neuropeptide Y gene family. Herzog, H., Hort, Y., Schneider, R., Shine, J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  6. Coenzyme A glutathione disulfide. A potent vasoconstrictor derived from the adrenal gland. Schlüter, H., Meissner, M., van der Giet, M., Tepel, M., Bachmann, J., Gross, I., Nordhoff, E., Karas, M., Spieker, C., Witzel, H. Circ. Res. (1995) [Pubmed]
  7. Synaptotagmin: a membrane constituent of neuropeptide-containing large dense-core vesicles. Walch-Solimena, C., Takei, K., Marek, K.L., Midyett, K., Südhof, T.C., De Camilli, P., Jahn, R. J. Neurosci. (1993) [Pubmed]
  8. Neuropeptide Y inhibits forskolin-stimulated adenylate cyclase in bovine adrenal chromaffin cells via a pertussis toxin-sensitive process. Zhu, J., Li, W., Toews, M.L., Hexum, T.D. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  9. Neuropeptide Y enhances ATP-induced formation of inositol phosphates in chromaffin cells. Zheng, J., Zhang, P., Toews, M., Hexum, T.D. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  10. Neuropeptide Y secretion from bovine chromaffin cells inhibits cyclic AMP accumulation. Zheng, J., Zhou, G., Hexum, T.D. Life Sci. (2000) [Pubmed]
  11. Subcellular fractionation of bovine ganglion stellatum: co-storage of noradrenaline, Met-enkephalin and neuropeptide Y in large 'dense-cored' vesicles. Bastiaensen, E., Miserez, B., De Potter, W. Brain Res. (1988) [Pubmed]
  12. Linkage mapping of NPY to bovine chromosome 4. Thue, T.D., Buchanan, F.C. Anim. Genet. (2004) [Pubmed]
  13. Immunocytochemical localization of vasoactive intestinal peptide and neuropeptide Y in the bovine ovary. Hulshof, S.C., Dijkstra, G., Van der Beek, E.M., Bevers, M.M., Figueiredo, J.R., Beckers, J.F., Van den Hurk, R. Biol. Reprod. (1994) [Pubmed]
  14. Role of sulfhydryl groups in Y2 neuropeptide Y receptor binding activity. Li, W., MacDonald, R.G., Hexum, T.D. J. Biol. Chem. (1992) [Pubmed]
  15. Neuropeptide Y in bovine adrenal glands: distribution and characterization. Majane, E.A., Alho, H., Kataoka, Y., Lee, C.H., Yang, H.Y. Endocrinology (1985) [Pubmed]
  16. An immunohistochemical study of neuropeptide Y in the bovine pineal gland. Phansuwan-Pujito, P., Pramaulkijja, S., Govitrapong, P., Møller, M. J. Pineal Res. (1993) [Pubmed]
  17. Neuropeptide-induced [Ca2+]i transients in cultured bovine trabecular cells. Ohuchi, T., Tanihara, H., Yoshimura, N., Kuriyama, S., Ito, S., Honda, Y. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  18. Sequence and expression of a neuropeptide Y receptor cDNA. Rimland, J., Xin, W., Sweetnam, P., Saijoh, K., Nestler, E.J., Duman, R.S. Mol. Pharmacol. (1991) [Pubmed]
  19. Inhibitory effect of neuropeptide Y (NPY) on the in vitro activity of dopamine-beta-hydroxylase. Cheng, J.T., Chang, C.L., Tsai, C.L. Neurosci. Lett. (1992) [Pubmed]
  20. Injection of neuropeptide Y into the third cerebroventricle differentially influences pituitary secretion of luteinizing hormone and growth hormone in ovariectomized cows. Thomas, M.G., Gazal, O.S., Williams, G.L., Stanko, R.L., Keisler, D.H. Domest. Anim. Endocrinol. (1999) [Pubmed]
  21. Specific 125I neuropeptide Y binding to intact cultured bovine adrenal medulla capillary endothelial cells. Sanabria, P., Silva, W.I. Microcirculation (New York, N.Y. : 1994) (1994) [Pubmed]
  22. Presynaptic inhibitory effects of the peptides NPY, PYY and PP on nicotinic EPSPs in guinea-pig gastric myenteric neurones. Schemann, M., Tamura, K. J. Physiol. (Lond.) (1992) [Pubmed]
  23. Recapture after exocytosis causes differential retention of protein in granules of bovine chromaffin cells. Perrais, D., Kleppe, I.C., Taraska, J.W., Almers, W. J. Physiol. (Lond.) (2004) [Pubmed]
  24. Nicotine-induced exocytotic norepinephrine release in guinea-pig heart, human atrium and bovine adrenal chromaffin cells: modulation by single components of ischaemia. Krüger, C., Haunstetter, A., Gerber, S., Serf, C., Kaufmann, A., Kübler, W., Haass, M. J. Mol. Cell. Cardiol. (1995) [Pubmed]
  25. Neuropeptide Y, enkephalin and noradrenaline coexist in sympathetic neurons innervating the bovine spleen. Biochemical and immunohistochemical evidence. Fried, G., Terenius, L., Brodin, E., Efendic, S., Dockray, G., Fahrenkrug, J., Goldstein, M., Hökfelt, T. Cell Tissue Res. (1986) [Pubmed]
  26. Multiple effects of neuropeptide Y, substance P and vasoactive intestinal polypeptide on progesterone and oxytocin release from bovine corpus luteum in vitro. Miyamoto, A., Brückmann, A., von Lützow, H., Schams, D. J. Endocrinol. (1993) [Pubmed]
  27. Effect of neuropeptide Y on GnRH-induced LH release from bovine anterior pituitary cell cultures derived from heifers in a follicular, luteal or ovariectomized state. Denniston, D.J., Thomas, M.G., Kane, K.K., Roybal, C.N., Canales, L., Hallford, D.M., Remmenga, M.D., Hawkins, D.E. Anim. Reprod. Sci. (2003) [Pubmed]
 
WikiGenes - Universities