Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

S100A8 - S100 calcium binding protein A8

Bos taurus

Doussiere, J. et al., Hitomi, J. et al.

Doussiere, Bouzidi, Vignais,

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High impact information on MGC137009

It was structurally homologous with MRP/calgranulin proteins (MRP8/calgranulin A and MRP14/calgranulin B), members of the S100 protein family, which are abundantly found in the cytoplasm of granulocytes and macrophages [1].
In the absence of S100A8/A9, oxidase activation departed from michaelian kinetics above a critical threshold concentration of cytosolic phox proteins [2].
Addition of S100A8/A9 to the cell-free system rendered the kinetics fully michaelian [2].
The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils [2].

Analytical, diagnostic and therapeutic context of MGC137009

This led us to check by immunoprecipitation and protein fractionation whether the cytosolic phox proteins could bind to S100A8/A9 [2].

References

A novel calcium-binding protein in amniotic fluid, CAAF1: its molecular cloning and tissue distribution. Hitomi, J., Yamaguchi, K., Kikuchi, Y., Kimura, T., Maruyama, K., Nagasaki, K. J. Cell. Sci. (1996) [Pubmed]
The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils. Doussiere, J., Bouzidi, F., Vignais, P.V. Eur. J. Biochem. (2002) [Pubmed]

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