The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

S100a8  -  S100 calcium binding protein A8

Rattus norvegicus

Synonyms: Calgranulin-A, MRP-8, Migration inhibitory factor-related protein 8, Mrp8, Protein S100-A8, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of S100a8

  • Calcium-binding proteins MRP 8 and 14 in a Staphylococcus aureus infection model: role of therapy, inflammation, and infection persistence [1].
  • LPS-induced overexpression of p8 mRNA in vivo confirmed the adverse effect of endotoxemia on pancreas and its overexpression in vitro demonstrated a direct interaction of LPS with pancreatic cells [2].

High impact information on S100a8

  • On the other hand, the levels of a 10.1-kDa and a 13.0-kDa protein, identified as migration inhibitory factor-related proteins (MRP), MRP-8 and MRP-14, respectively, began to increase from an early stage of acute rejection [3].
  • The energy-dependent cyclic nucleotide cellular efflux is operative in numerous eukaryotic cells and could be mediated by multidrug resistance proteins MRP4, MRP5, and MRP8 [4].
  • The predicted amino acid sequence of rat MRP8 and MRP14 is 60-80% identical with that from human and mouse [5].
  • Half of the infected rats were depleted of neutrophils; these rats exhibited significantly lower MRP 8/14 concentrations on all days sampled, regardless of the level of infection [1].
  • In abscess fluid, interleukin-6, as a representative marker of inflammation, correlated with MRP8/14, whereas ionized calcium and zinc did not [1].

Biological context of S100a8


Analytical, diagnostic and therapeutic context of S100a8

  • Using commercial and developed enzyme immunoassays, we assayed for MRP8/14 in sterile-filtered abscess fluid from tissue-cage-implanted rats and rabbits [1].
  • Thirty-day-old abscesses with log 6 bacterial counts and low neutrophil counts showed low concentrations of MRP 8/14 in these models [1].
  • In AR4-2J cells, basal p8 mRNA expression was very low and increased in a time- and dose-dependent manner after treatment with LPS [2].
  • In vitro, pancreatic acinar AR4-2J cells were cultivated with 0.1, 1, or 10 micrograms/ml LPS for 6, 12, or 24 h. p8 mRNA expression was monitored by Northern blotting [2].


  1. Calcium-binding proteins MRP 8 and 14 in a Staphylococcus aureus infection model: role of therapy, inflammation, and infection persistence. Herndon, B.L., Abbasi, S., Bennett, D., Bamberger, D. J. Lab. Clin. Med. (2003) [Pubmed]
  2. Lipopolysaccharides induce p8 mRNA expression in vivo and in vitro. Jiang, Y.F., Vaccaro, M.I., Fiedler, F., Calvo, E.L., Iovanna, J.L. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  3. Novel application of ProteinChip technology exploring acute rejection markers of rat small bowel transplantation. Yamayoshi, Y., Watanabe, T., Tanabe, M., Hoshino, K., Matsumoto, K., Morikawa, Y., Shimadzu, M., Kitajima, M., Tanigawara, Y. Transplantation (2006) [Pubmed]
  4. Contribution of multidrug resistance protein MRP5 in control of cyclic guanosine 5'-monophosphate intracellular signaling in anterior pituitary cells. Andric, S.A., Kostic, T.S., Stojilkovic, S.S. Endocrinology (2006) [Pubmed]
  5. Expression and cloning of migration inhibitory factor-related protein (MRP)8 and MRP14 in arthritis-susceptible rats. Imamichi, T., Uchida, I., Wahl, S.M., McCartney-Francis, N. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
WikiGenes - Universities