The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

MRPS12  -  mitochondrial ribosomal protein S12

Homo sapiens

Synonyms: 28S ribosomal protein S12, mitochondrial, MPR-S12, MRP-S12, MT-RPS12, RPMS12, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MRPS12


High impact information on MRPS12

  • A Pentatricopeptide Repeat Protein Facilitates the trans-Splicing of the Maize Chloroplast rps12 Pre-mRNA [2].
  • Microarray analysis of RNA that coimmunoprecipitates with PPR4 showed that PPR4 is associated in vivo with the first intron of the plastid rps12 pre-mRNA, a group II intron that is transcribed in segments and spliced in trans. ppr4 mutants were recovered through a reverse-genetic screen and shown to be defective for rps12 trans-splicing [2].
  • Polysome analysis showed that there was no significant translational control of mt translation factor (EF-Tumt, ribosomal proteins L7/L12mt and S12mt) mRNA expression during differentiation [3].
  • The human gene RPMS12 encodes a protein similar to bacterial ribosomal protein S12 and is proposed to represent the human mitochondrial orthologue [4].
  • Human cells contain at least four structurally distinct RPMS12 mRNAs that differ in their 5'-untranslated region (5'-UTR) as a result of alternate splicing and of 5' end heterogeneity [4].

Biological context of MRPS12

  • RPMS12 reporter gene expression in cultured human cells supports the idea that the gene product is mitochondrial and is localized to the inner membrane [4].
  • These findings indicate a complex, multilevel regulation of RPMS12 gene expression in response to signals mediating growth, tissue specialization, and probably metabolic needs [4].
  • Another candidate gene is the mitochondrial ribosomal protein S12, which interacts with the ribosomal RNA gene and in bacteria can harbor aminoglycoside resistance mutations [5].
  • Although regulatory mutations affecting either gene could still be involved in the phenotype, structural gene mutations affecting SARSM or RPMS12 can be excluded from consideration as the cause of DFNA4-linked deafness, at least in the families identified thus far [6].


  1. Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus. Shah, Z.H., Migliosi, V., Miller, S.C., Wang, A., Friedman, T.B., Jacobs, H.T. Genomics (1998) [Pubmed]
  2. A Pentatricopeptide Repeat Protein Facilitates the trans-Splicing of the Maize Chloroplast rps12 Pre-mRNA. Schmitz-Linneweber, C., Williams-Carrier, R.E., Williams-Voelker, P.M., Kroeger, T.S., Vichas, A., Barkan, A. Plant Cell (2006) [Pubmed]
  3. Down-regulation of the mitochondrial translation system during terminal differentiation of HL-60 cells by 12-O-tetradecanoyl-1-phorbol-13-acetate: comparison with the cytoplasmic translation system. Takeuchi, N., Ueda, T. J. Biol. Chem. (2003) [Pubmed]
  4. Expression of the gene for mitoribosomal protein S12 is controlled in human cells at the levels of transcription, RNA splicing, and translation. Mariottini, P., Shah, Z.H., Toivonen, J.M., Bagni, C., Spelbrink, J.N., Amaldi, F., Jacobs, H.T. J. Biol. Chem. (1999) [Pubmed]
  5. Genetic factors in aminoglycoside toxicity. Fischel-Ghodsian, N. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
  6. Novel coding-region polymorphisms in mitochondrial seryl-tRNA synthetase (SARSM) and mitoribosomal protein S12 (RPMS12) genes in DFNA4 autosomal dominant deafness families. Shah, Z.H., Toompuu, M., Hakkinen, T., Rovio, A.T., van Ravenswaay, C., De Leenheer, E.M., Smith, R.J., Cremers, F.P., Cremers, C.W., Jacobs, H.T. Hum. Mutat. (2001) [Pubmed]
WikiGenes - Universities