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Gene Review

PTCD1  -  pentatricopeptide repeat domain 1

Homo sapiens

Synonyms: KIAA0632, Pentatricopeptide repeat-containing protein 1, mitochondrial
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Disease relevance of PTCD1

  • In 11 patients PTCD was performed as a preoperative measure either to outline tumor extension or to treat cholangitis [1].
  • PTCD caused a bacterial peritonitis, of which the patient died [1].
  • The use of ultrasound-guided PTCD in 49 patients with hilar cholangiocarcinoma was evaluated [1].
  • PTCD was successful in treating eight of ten patients with cholangitis and 12 of 16 patients with pruritus [1].
  • Arrest of PTCD-induced hemorrhage using a covered vascular metal stent [2].

High impact information on PTCD1


Chemical compound and disease context of PTCD1


Biological context of PTCD1


Anatomical context of PTCD1


Associations of PTCD1 with chemical compounds

  • PTC and PTCD are left for those patients in whom ERCP has failed [16].

Other interactions of PTCD1


Analytical, diagnostic and therapeutic context of PTCD1


  1. Ultrasound-guided percutaneous transhepatic cholangiography and drainage in patients with hilar cholangiocarcinoma. Laméris, J.S., Hesselink, E.J., Van Leeuwen, P.A., Nijs, H.G., Meerwaldt, J.H., Terpstra, O.T. Semin. Liver Dis. (1990) [Pubmed]
  2. Arrest of PTCD-induced hemorrhage using a covered vascular metal stent. Bülau, S., Berger, H., Dittler, H.J., Schumacher, C., Weigert, N., Born, P., Fink, U., Rösch, T. Endoscopy. (2000) [Pubmed]
  3. Cytoplasmic male sterility: a window to the world of plant mitochondrial-nuclear interactions. Chase, C.D. Trends Genet. (2007) [Pubmed]
  4. A Pentatricopeptide Repeat Protein Facilitates the trans-Splicing of the Maize Chloroplast rps12 Pre-mRNA. Schmitz-Linneweber, C., Williams-Carrier, R.E., Williams-Voelker, P.M., Kroeger, T.S., Vichas, A., Barkan, A. Plant Cell (2006) [Pubmed]
  5. Genome-wide analysis of Arabidopsis pentatricopeptide repeat proteins reveals their essential role in organelle biogenesis. Lurin, C., Andrés, C., Aubourg, S., Bellaoui, M., Bitton, F., Bruyère, C., Caboche, M., Debast, C., Gualberto, J., Hoffmann, B., Lecharny, A., Le Ret, M., Martin-Magniette, M.L., Mireau, H., Peeters, N., Renou, J.P., Szurek, B., Taconnat, L., Small, I. Plant Cell (2004) [Pubmed]
  6. Change in serum and biliary esterified bile acids in patients with extrahepatic cholestasis during percutaneous transhepatic cholangiodrainage. Suzuki, S., Nakazawa, S., Okuyama, S., Okumura, K., Takagi, K. Gastroenterol. Jpn. (1988) [Pubmed]
  7. The role of the LRPPRC (leucine-rich pentatricopeptide repeat cassette) gene in cytochrome oxidase assembly: mutation causes lowered levels of COX (cytochrome c oxidase) I and COX III mRNA. Xu, F., Morin, C., Mitchell, G., Ackerley, C., Robinson, B.H. Biochem. J. (2004) [Pubmed]
  8. A pentatricopeptide repeat protein is a site recognition factor in chloroplast RNA editing. Okuda, K., Nakamura, T., Sugita, M., Shimizu, T., Shikanai, T. J. Biol. Chem. (2006) [Pubmed]
  9. The petunia restorer of fertility protein is part of a large mitochondrial complex that interacts with transcripts of the CMS-associated locus. Gillman, J.D., Bentolila, S., Hanson, M.R. Plant J. (2007) [Pubmed]
  10. RNA editing in plant organelles: machinery, physiological function and evolution. Shikanai, T. Cell. Mol. Life Sci. (2006) [Pubmed]
  11. A pentatricopeptide repeat-containing gene that promotes the processing of aberrant atp6 RNA of cytoplasmic male-sterile rice. Kazama, T., Toriyama, K. FEBS Lett. (2003) [Pubmed]
  12. Fertility restorer locus Rf1 of sorghum (Sorghum bicolor L.) encodes a pentatricopeptide repeat protein not present in the colinear region of rice chromosome 12. Klein, R.R., Klein, P.E., Mullet, J.E., Minx, P., Rooney, W.L., Schertz, K.F. Theor. Appl. Genet. (2005) [Pubmed]
  13. A chloroplast-localized PPR protein required for plastid ribosome accumulation. Williams, P.M., Barkan, A. Plant J. (2003) [Pubmed]
  14. The effect of T cell depletion with Campath-1M on immune reconstitution after chemotherapy and allogeneic bone marrow transplant as treatment for leukaemia. Lowdell, M.W., Craston, R., Ray, N., Koh, M., Galatowicz, G., Prentice, H.G. Bone Marrow Transplant. (1998) [Pubmed]
  15. Pitfall: a pseudo tumor within the left liver lobe presenting with abdominal pain, jaundice and severe weight loss. Widjaja, A., Rosenthal, H., Bleck, J., Walter, B., Gölkel, C., Rademaker, J., Holstein, A., Gebel, M., Manns, M.P. Ultraschall in der Medizin (Stuttgart, Germany : 1980) (1999) [Pubmed]
  16. The radiology of jaundice. Lunderquist, A. Baillieres Clin. Gastroenterol. (1989) [Pubmed]
  17. Towards an analysis of the rice mitochondrial proteome. Heazlewood, J.L., Howell, K.A., Whelan, J., Millar, A.H. Plant Physiol. (2003) [Pubmed]
  18. RNA immunoprecipitation and microarray analysis show a chloroplast Pentatricopeptide repeat protein to be associated with the 5' region of mRNAs whose translation it activates. Schmitz-Linneweber, C., Williams-Carrier, R., Barkan, A. Plant Cell (2005) [Pubmed]
  19. A ten-year study on non-surgical treatment of postoperative bile leakage. Chen, X.P., Peng, S.Y., Peng, C.H., Liu, Y.B., Shi, L.B., Jiang, X.C., Shen, H.W., Xu, Y.L., Fang, S.B., Rui, J., Xia, X.H., Zhao, G.H. World J. Gastroenterol. (2002) [Pubmed]
  20. Chemical Changes and Overexpressed Genes in Sweet Basil (Ocimum basilicum L.) upon Methyl Jasmonate Treatment. Li, Z., Wang, X., Chen, F., Kim, H.J. J. Agric. Food Chem. (2007) [Pubmed]
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