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Gene Review:

D19Mit91 - DNA segment, Chr 19, Massachusetts...

Mus musculus

Kluge, R. et al., Grimm, C. et al.

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Disease relevance of D19Mit91

RESULTS: In female NZO x F1 backcross mice, two major quantitative trait loci for variables of obesity (body weight, body mass index, total body fat) and insulin resistance (hyperinsulinaemia) were identified on chromosomes 5 (Nob1) and 19 (Nob2) close to the markers D5Mit392 and D19Mit91 [1].

High impact information on D19Mit91

Our linkage studies yielded a precise localization of the ak gene 0.6 +/- 0.3 cM proximal to the microsatellite marker D19Mit10 and 0.7 +/- 0.4 cM distal to D19Mit4 and D19Mit91 [2].

References

Quantitative trait loci for obesity and insulin resistance (Nob1, Nob2) and their interaction with the leptin receptor allele (LeprA720T/T1044I) in New Zealand obese mice. Kluge, R., Giesen, K., Bahrenberg, G., Plum, L., Ortlepp, J.R., Joost, H.G. Diabetologia (2000) [Pubmed]
Aphakia (ak), a mouse mutation affecting early eye development: fine mapping, consideration of candidate genes and altered Pax6 and Six3 gene expression pattern. Grimm, C., Chatterjee, B., Favor, J., Immervoll, T., Löster, J., Klopp, N., Sandulache, R., Graw, J. Dev. Genet. (1998) [Pubmed]

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