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Gene Review

Ctsz  -  cathepsin Z

Mus musculus

Synonyms: AI787083, AU019819, CTSX, Cathepsin Z, D2Wsu143e, ...
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High impact information on Ctsz

  • Treatment of cells with a neutralizing anti-cathepsin X antibody significantly reduced Matrigel invasion of PyMT;ctsb(-/-) cells but did not affect invasion of PyMT;ctsb(+/+) or PyMT;ctsb(+/-) cells, indicating a compensatory function of cathepsin X in CTSB-deficient tumor cells [1].
  • Interestingly, cell surface labeling of cysteine cathepsins by the active site probe DCG-04 detected up-regulation of cathepsin X on PyMT;ctsb(-/-) cells [1].
  • Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location [2].
  • Fluorescent in situ hybridization experiments revealed that the human cathepsin Z gene maps to chromosome 20q13, a location that differs from all cysteine proteinase genes mapped to date [2].
  • Cathepsin Z is also ubiquitously distributed in cancer cell lines and in primary tumors from different sources, suggesting that this enzyme may participate in tumor progression as reported for other cathepsins [2].

Biological context of Ctsz

  • Murine cathepsin Z was mapped to chromosome 2, a region with synteny homology to a region of human chromosome 20 to which human cathepsin Z has been mapped previously [3].
  • Nucleotide sequence analysis revealed that the isolated cDNA codes for a polypeptide of 303 amino acids, tentatively called cathepsin Z, that exhibits structural features characteristic of cysteine proteinases [2].

Analytical, diagnostic and therapeutic context of Ctsz

  • Northern blot analysis revealed ubiquitous expression of murine cathepsin Z [3].


  1. Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Vasiljeva, O., Papazoglou, A., Krüger, A., Brodoefel, H., Korovin, M., Deussing, J., Augustin, N., Nielsen, B.S., Almholt, K., Bogyo, M., Peters, C., Reinheckel, T. Cancer Res. (2006) [Pubmed]
  2. Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location. Santamaría, I., Velasco, G., Pendás, A.M., Fueyo, A., López-Otín, C. J. Biol. Chem. (1998) [Pubmed]
  3. Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization. Deussing, J., von Olshausen, I., Peters, C. Biochim. Biophys. Acta (2000) [Pubmed]
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