Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Defb4 - defensin beta 4

Rattus norvegicus

Synonyms: BD-2, BD-4, Beta-defensin 4, Defb2, Defb3, ...

Com, E. et al., Monteiro, F.M. et al., Hamawy, M.M. et al., Jia, H.P. et al., Jia, H.P. et al.

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Disease relevance of Defb4

The decreased body weight and the tendency to increased reflex tachycardia in RBD-2 rats may suggest that this type of maternal malnutrition during lactation is more critical than during pregnancy [1].

High impact information on Defb4

We recently characterized rat homologs (RBD-1, RBD-2) of the human genes and used these sequences to identify novel mouse genes [2].
In the lung, RBD-1 mRNA expression localized to the tracheal epithelium while RBD-2 was expressed in alveolar type II cells [3].
In rat interstitial tissue, resident macrophages expressed most of the defensins studied, whereas Leydig cells produced only RBD-2 [4].
In the rat, all alpha- and beta-defensins except RNP-4 were expressed within the testis, whereas alpha-defensins RNP1-2, RNP-4, and beta-defensins RBD-1 and RBD-2 were present within the epididymis [4].
Here we report the isolation of a monoclonal antibody, mAb BD2, to a 72 kDa protein that becomes rapidly tyrosine phosphorylated after Fc epsilon RI aggregation [5].

Biological context of Defb4

Baseline mean arterial pressure and heart rate of both RBD-1 and RBD-2 rats were comparable to those of controls [1].

References

Influence of a multideficient diet from northeastern Brazil on resting blood pressure and baroreflex sensitivity in conscious, freely moving rats. Monteiro, F.M., Lahlou, S., Albuquerque, J.A., Cabral, A.M. Braz. J. Med. Biol. Res. (2001) [Pubmed]
A novel murine beta -defensin expressed in tongue, esophagus, and trachea. Jia, H.P., Wowk, S.A., Schutte, B.C., Lee, S.K., Vivado, A., Tack, B.F., Bevins, C.L., McCray, P.B. J. Biol. Chem. (2000) [Pubmed]
Molecular cloning and characterization of rat genes encoding homologues of human beta-defensins. Jia, H.P., Mills, J.N., Barahmand-Pour, F., Nishimura, D., Mallampali, R.K., Wang, G., Wiles, K., Tack, B.F., Bevins, C.L., McCray, P.B. Infect. Immun. (1999) [Pubmed]
Expression of antimicrobial defensins in the male reproductive tract of rats, mice, and humans. Com, E., Bourgeon, F., Evrard, B., Ganz, T., Colleu, D., Jégou, B., Pineau, C. Biol. Reprod. (2003) [Pubmed]
Fc epsilon RI aggregation induces tyrosine phosphorylation of a novel 72 kDa protein downstream of Syk. Hamawy, M.M., Fischler, C., Zhang, J., Siraganian, R.P. Biochem. Biophys. Res. Commun. (1997) [Pubmed]

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