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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MARC1  -  mitochondrial amidoxime reducing component 1

Homo sapiens

Synonyms: FLJ22390, MOSC domain-containing protein 1, MOSC1, Mitochondrial amidoxime-reducing component 1, Moco sulfurase C-terminal domain-containing protein 1, ...
 
 
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High impact information on MOSC1

  • Also the inherent immortality of the embryonic stem cells implies that replicative senescence (Hayflick L (1997) Biochem Mosc 62: 1180-1190) as possibly aging of species are epigenetic phenomena [1].
  • These MOSC domains contain an absolutely conserved cysteine and occur either as stand-alone forms such as the bacterial YiiM proteins, or fused to other domains such as a NifS-like catalytic domain in Molybdenum cofactor sulfurase [2].
  • MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases [2].
 

Associations of MOSC1 with chemical compounds

  • The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters [2].
 

Analytical, diagnostic and therapeutic context of MOSC1

  • The study was done on culture isolates from Jan 2000 to June 2002 attending the department of medicine, MOSC medical college hospital, Kolenchery, Kerala, India. DNA of 45 culture isolates were amplified by multiplex PCR using two sets of previously described primers, G1, G2 and B 64-I, B 64-II [3].

References

  1. Chaperones and longevity. Krøll, J. Biogerontology. (2005) [Pubmed]
  2. MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases. Anantharaman, V., Aravind, L. FEMS Microbiol. Lett. (2002) [Pubmed]
  3. Multiplex PCR on leptospiral isolates from Kolenchery, Kerala, India. Sugathan, S., Varghese, T.P. Indian journal of medical microbiology. (2005) [Pubmed]
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