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Gene Review

MOCOS  -  molybdenum cofactor sulfurase

Homo sapiens

Synonyms: FLJ20733, HMCS, MCS, MOS, MoCo sulfurase, ...
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Disease relevance of MOCOS

  • Psychometric variables were assessed each week by means of the West Haven-Yale Multidimensional Pain Inventory (MPI), Pittsburgh Sleep Quality Index (PSQI), Medical outcome survey-short form (MOS SF-36), the Pain Disability Index (PDI), and the Fibromyalgia Impact Questionnaire (FIQ) [1].
  • Furthermore, LL, SC, LL + MOS, or SC + MOS significantly improved antibody titres against Newcastle disease virus and lymphocyte proliferation of broilers (p < 0.05) [2].

Psychiatry related information on MOCOS

  • The presence of sleep disorders and the characteristics of the BDZ used were not associated with any score in the MOS SF-36 questionnaire, whereas the Prime diagnosis was the most important predictor, since subjects with depression and/or anxiety had a lower mean score on each scale than subjects without disorders [3].

High impact information on MOCOS

  • Supporting these findings, recombinant C-terminal domain of the human molybdenum cofactor sulfurase exhibited N-reductive activity in vitro, which was strictly dependent on molybdenum cofactor [4].
  • We assessed HRQL using the MOS 36-Item Short Form (SF-36) questionnaire, and blood pressure (BP) was measured under standardized conditions [5].
  • The human molybdenum cofactor sulfurase (HMCS) gene, the human ma-l homologue, is therefore a candidate gene responsible for classical xanthinuria type II, which involves both XDH and AO deficiencies [6].
  • In this study, we cloned the HMCS gene from a cDNA library prepared from liver [6].
  • In two independent patients with classical xanthinuria type II, we identified a C to T base substitution at nucleotide 1255 in the HMCS gene that should cause a CGA (Arg) to TGA (Ter) nonsense substitution at codon 419 [6].

Biological context of MOCOS


Associations of MOCOS with chemical compounds

  • The chromatography was performed on a MOS Hypersil (C(8)) column and was optimized by investigating the effects of methanol (7.5-20%), acetonitrile (5-7%), tetrabutylammonium hydrogen-sulphate (TBA, 0-90 mM) and acetate buffer (pH 3.5, 60-100 mM) on the retention of fetindomide and mitindomide [10].
  • Health-related quality of life was measured using the MOS 36-item Short Form Health Survey (SF-36), and the US Centers for Disease Control healthy day's items [11].
  • However, compared to the control, LL, SC, LL + MOS, or SC + MOS significantly decreased malondialdehyde concentration in serum, thigh, and heart of broilers [2].

Analytical, diagnostic and therapeutic context of MOCOS

  • HRQoL was measured by the eight MOS 36-Item Short-Form Health Survey (SF-36) scales [12].


  1. Delta-9-THC based monotherapy in fibromyalgia patients on experimentally induced pain, axon reflex flare, and pain relief. Schley, M., Legler, A., Skopp, G., Schmelz, M., Konrad, C., Rukwied, R. Current medical research and opinion. (2006) [Pubmed]
  2. Influence of mannan oligosaccharide, Ligustrum lucidum and Schisandra chinensis on parameters of antioxidative and immunological status of broilers. Ma, D., Li, Q., Du, J., Liu, Y., Liu, S., Shan, A. Archives of animal nutrition (2006) [Pubmed]
  3. Health-related quality of life in older people using benzodiazepines: a cross-sectional study. Gelatti, U., Samani, F., Donato, F., Covolo, L., Mazzaglia, G., Cremaschini, F., Simon, G., Leggieri, G., Balestrieri, M. Annali di igiene : medicina preventiva e di comunit??. (2006) [Pubmed]
  4. Identification of the Missing Component in the Mitochondrial Benzamidoxime Prodrug-converting System as a Novel Molybdenum Enzyme. Havemeyer, A., Bittner, F., Wollers, S., Mendel, R., Kunze, T., Clement, B. J. Biol. Chem. (2006) [Pubmed]
  5. Association between awareness, treatment, and control of hypertension, and quality of life among older adults in Spain. Banegas, J.R., Guallar-Castillón, P., Rodríguez-Artalejo, F., Graciani, A., López-García, E., Ruilope, L.M. Am. J. Hypertens. (2006) [Pubmed]
  6. Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II. Ichida, K., Matsumura, T., Sakuma, R., Hosoya, T., Nishino, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  7. MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases. Anantharaman, V., Aravind, L. FEMS Microbiol. Lett. (2002) [Pubmed]
  8. Which instrument is more suitable to assess health-related quality of life: Nottingham Health Profile or Short-Form-36? Jagsch, R., Pils, K. Wiener medizinische Wochenschrift (1946) (2006) [Pubmed]
  9. Oculomotricity in childhood: is the normal range the same as in adults? Mezzalira, R., Neves, L.C., Maudonnet, O.A., Bilécki, M.M., Avila, F.G. Revista brasileira de otorrinolaringologia (English ed.) (2005) [Pubmed]
  10. Stability indicating assay for fetindomide (NSC 373965), a potential prodrug of mitindomide (NSC 284356), employing high-performance liquid chromatography. Umprayn, K., Stella, V.J., Riley, C.M. Journal of pharmaceutical and biomedical analysis. (1987) [Pubmed]
  11. Impact of chronic disease on quality of life in the Bella Coola Valley. Thommasen, H.V., Zhang, W. Rural and remote health [electronic resource]. (2006) [Pubmed]
  12. The ACTIVE Cognitive Training Trial and Health-Related Quality of Life: Protection That Lasts for 5 Years. Wolinsky, F.D., Unverzagt, F.W., Smith, D.M., Jones, R., Stoddard, A., Tennstedt, S.L. J. Gerontol. A Biol. Sci. Med. Sci. (2006) [Pubmed]
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