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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Capsicum


Psychiatry related information on Capsicum

  • Our results show that both treatments, the aqueous red pepper extract and low doses of capsaicin on pregnant rats. produce an increment on escape response latency due to a thermonociceptive stimulus [6].

High impact information on Capsicum


Chemical compound and disease context of Capsicum


Biological context of Capsicum

  • These data demonstrate that green pepper, tomato, pineapple, strawberry and carrot juice have greater ability to inhibit endogenous nitrosation than would be expected based solely on their ascorbate content [16].
  • Although PAP is present as a single-copy gene in the bell pepper genome, Southern blots using PAP2 as a probe revealed multiple homologous copies [17].
  • CONCLUSION: Chronic occupational exposure to chili peppers is associated with complaints of cough but does not alone lead to decreased responsiveness of capsaicin-sensitive nerves when assessed by cough threshold [18].
  • This enzyme activity is also inhibited by both red pepper extract (80% inhibition with 50 microliter) and capsaicin (IC50 between 0.3-1 microM) in a dose dependent manner [19].
  • RP-HPLC followed by PCA and SRA can be successfully used for the study of the impact of environmental conditions on the decomposition of carotenoid pigments of paprika powders [20].

Anatomical context of Capsicum


Associations of Capsicum with chemical compounds


Gene context of Capsicum

  • Recently a cDNA clone, vanilloid receptor subtype-1 (VR1), was isolated and found to encode an ion channel that is activated by both capsaicin, the pain producing compound in chili peppers, and by noxious thermal stimuli [30].
  • METHODS: cDNA clones coding for profilin were obtained by RT-PCR from total RNA of tomato and bell pepper fruits, sequenced and expressed as non-fusion proteins in ESCHERICHIA COLI [31].
  • Endovanilloids are defined as endogenous ligands of the transient receptor potential vanilloid type 1 (TRPV1) protein, a nonselective cation channel that belongs to the large family of TRP ion channels, and is activated by the pungent ingredient of hot chilli peppers, capsaicin [32].
  • In bell pepper, a gene encoding a major plastid-lipid associated protein is expressed as both partially and totally spliced transcripts (respectively PAP2 and PAP1) [17].
  • On the other hand, RNA analyses of tobacco plants transformed with the bell pepper PAP revealed the presence of both totally and incompletely spliced transcripts [17].

Analytical, diagnostic and therapeutic context of Capsicum


  1. Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase. Adam, P., Hecht, S., Eisenreich, W., Kaiser, J., Grawert, T., Arigoni, D., Bacher, A., Rohdich, F. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells. Mori, A., Lehmann, S., O'Kelly, J., Kumagai, T., Desmond, J.C., Pervan, M., McBride, W.H., Kizaki, M., Koeffler, H.P. Cancer Res. (2006) [Pubmed]
  3. Ca2+/calmodulin modulates TRPV1 activation by capsaicin. Rosenbaum, T., Gordon-Shaag, A., Munari, M., Gordon, S.E. J. Gen. Physiol. (2004) [Pubmed]
  4. Capsaicin consumption, Helicobacter pylori positivity and gastric cancer in Mexico. López-Carrillo, L., López-Cervantes, M., Robles-Díaz, G., Ramírez-Espitia, A., Mohar-Betancourt, A., Meneses-García, A., López-Vidal, Y., Blair, A. Int. J. Cancer (2003) [Pubmed]
  5. Analgesic effect of capsaicin in idiopathic trigeminal neuralgia. Fusco, B.M., Alessandri, M. Anesth. Analg. (1992) [Pubmed]
  6. Capsaicin or feeding with red peppers during gestation changes the thermonociceptive response of rat offspring. Pellicer, F., Picazo, O., Gómez-Tagle, B., Roldán de la O, I. Physiol. Behav. (1996) [Pubmed]
  7. Molecular basis for species-specific sensitivity to "hot" chili peppers. Jordt, S.E., Julius, D. Cell (2002) [Pubmed]
  8. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Davis, J.B., Gray, J., Gunthorpe, M.J., Hatcher, J.P., Davey, P.T., Overend, P., Harries, M.H., Latcham, J., Clapham, C., Atkinson, K., Hughes, S.A., Rance, K., Grau, E., Harper, A.J., Pugh, P.L., Rogers, D.C., Bingham, S., Randall, A., Sheardown, S.A. Nature (2000) [Pubmed]
  9. Fibril assembly and carotenoid overaccumulation in chromoplasts: a model for supramolecular lipoprotein structures. Deruère, J., Römer, S., d'Harlingue, A., Backhaus, R.A., Kuntz, M., Camara, B. Plant Cell (1994) [Pubmed]
  10. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Huang, S.M., Bisogno, T., Trevisani, M., Al-Hayani, A., De Petrocellis, L., Fezza, F., Tognetto, M., Petros, T.J., Krey, J.F., Chu, C.J., Miller, J.D., Davies, S.N., Geppetti, P., Walker, J.M., Di Marzo, V. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  11. Activation by odorants of a multistate cation channel from olfactory cilia. Labarca, P., Simon, S.A., Anholt, R.R. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  12. Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L. Maoka, T., Mochida, K., Kozuka, M., Ito, Y., Fujiwara, Y., Hashimoto, K., Enjo, F., Ogata, M., Nobukuni, Y., Tokuda, H., Nishino, H. Cancer Lett. (2001) [Pubmed]
  13. Control of Aeromonas on minimally processed vegetables by decontamination with lactic acid, chlorinated water, or thyme essential oil solution. Uyttendaele, M., Neyts, K., Vanderswalmen, H., Notebaert, E., Debevere, J. Int. J. Food Microbiol. (2004) [Pubmed]
  14. Foreign body sarcoma: effects of foreign DNA, beta-carotene and paprika applied to the implant surface. Lavelle, S.M., Iomhair, M.M. Technology and health care : official journal of the European Society for Engineering and Medicine. (2000) [Pubmed]
  15. Physiological basis of salt tolerance in plants. Bernstein, L. Basic Life Sci. (1976) [Pubmed]
  16. Influence of fruit and vegetable juices on the endogenous formation of N-nitrosoproline and N-nitrosothiazolidine-4-carboxylic acid in humans on controlled diets. Helser, M.A., Hotchkiss, J.H., Roe, D.A. Carcinogenesis (1992) [Pubmed]
  17. Identification of a short interspersed repetitive element in partially spliced transcripts of the bell pepper (Capsicum annuum) PAP gene: new evolutionary and regulatory aspects on plant tRNA-related SINEs. Pozueta-Romero, J., Houlné, G., Schantz, R. Gene (1998) [Pubmed]
  18. Cough in hot pepper workers. Blanc, P., Liu, D., Juarez, C., Boushey, H.A. Chest (1991) [Pubmed]
  19. Inhibition of calcium and calmodulin-dependent phosphodiesterase activity in rats by capsaicin. Salimath, B.P., Satyanarayana, M.N. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  20. Effects of fluorescent light and vacuum packaging on the rate of decomposition of pigments in paprika (Capsicum annuum) powder determined by reversed-phase high-performance liquid chromatography. Morais, H., Ramos, A.C., Tibor, C., Forgács, E. Journal of chromatography. A. (2001) [Pubmed]
  21. Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells. Basu, S., Srivastava, P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  22. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. LaMotte, R.H., Lundberg, L.E., Torebjörk, H.E. J. Physiol. (Lond.) (1992) [Pubmed]
  23. Capsaicin induces cystatin S-like substances in submandibular saliva of the rat. Katsukawa, H., Ninomiya, Y. J. Dent. Res. (1999) [Pubmed]
  24. Accumulation and clearance of capsanthin in blood plasma after the ingestion of paprika juice in men. Oshima, S., Sakamoto, H., Ishiguro, Y., Terao, J. J. Nutr. (1997) [Pubmed]
  25. Some pungent principles of spices cause the adrenal medulla to secrete catecholamine in anesthetized rats. Kawada, T., Sakabe, S., Watanabe, T., Yamamoto, M., Iwai, K. Proc. Soc. Exp. Biol. Med. (1988) [Pubmed]
  26. Cysteine synthase from Capsicum annuum chromoplasts. Characterization and cDNA cloning of an up-regulated enzyme during fruit development. Römer, S., d'Harlingue, A., Camara, B., Schantz, R., Kuntz, M. J. Biol. Chem. (1992) [Pubmed]
  27. Problems with estimating vitamin C intakes. Sinha, R., Block, G., Taylor, P.R. Am. J. Clin. Nutr. (1993) [Pubmed]
  28. Identification of a cDNA for the plastid-located geranylgeranyl pyrophosphate synthase from Capsicum annuum: correlative increase in enzyme activity and transcript level during fruit ripening. Kuntz, M., Römer, S., Suire, C., Hugueney, P., Weil, J.H., Schantz, R., Camara, B. Plant J. (1992) [Pubmed]
  29. Chemoprotective effects of capsaicin and diallyl sulfide against mutagenesis or tumorigenesis by vinyl carbamate and N-nitrosodimethylamine. Surh, Y.J., Lee, R.C., Park, K.K., Mayne, S.T., Liem, A., Miller, J.A. Carcinogenesis (1995) [Pubmed]
  30. Molecular cloning of an N-terminal splice variant of the capsaicin receptor. Loss of N-terminal domain suggests functional divergence among capsaicin receptor subtypes. Schumacher, M.A., Moff, I., Sudanagunta, S.P., Levine, J.D. J. Biol. Chem. (2000) [Pubmed]
  31. Cloning and molecular and immunological characterisation of two new food allergens, Cap a 2 and Lyc e 1, profilins from bell pepper (Capsicum annuum) and Tomato (Lycopersicon esculentum). Willerroider, M., Fuchs, H., Ballmer-Weber, B.K., Focke, M., Susani, M., Thalhamer, J., Ferreira, F., Wüthrich, B., Scheiner, O., Breiteneder, H., Hoffmann-Sommergruber, K. Int. Arch. Allergy Immunol. (2003) [Pubmed]
  32. Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels. Van Der Stelt, M., Di Marzo, V. Eur. J. Biochem. (2004) [Pubmed]
  33. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. LaMotte, R.H., Shain, C.N., Simone, D.A., Tsai, E.F. J. Neurophysiol. (1991) [Pubmed]
  34. Effect of reduced glutathione on the stability of pigments in paprika powders studied by multiwavelength spectrometry and high-performance liquid chromatography. Cserháti, T., Forgács, E., Darwish, Y., Morais, H., Mota, T., Ramos, A.C. Journal of chromatography. A. (2002) [Pubmed]
  35. Afferent reinnervation after lung transplantation in the rat. Kawaguchi, A.T., Shirai, M., Yamano, M., Ishibashi-Ueda, H., Yamatodani, A., Kawashima, Y. J. Heart Lung Transplant. (1998) [Pubmed]
  36. Presence of an acidic glycoprotein in the serum of arthritic rats: modulation by capsaicin and curcumin. Joe, B., Rao, U.J., Lokesh, B.R. Mol. Cell. Biochem. (1997) [Pubmed]
  37. The effects of ripening stage and processing systems on vitamin C content in sweet peppers (Capsicum annuum L.). Martínez, S., López, M., González-Raurich, M., Bernardo Alvarez, A. International journal of food sciences and nutrition. (2005) [Pubmed]
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