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Gene Review

Pfkm  -  phosphofructokinase, muscle

Rattus norvegicus

Synonyms: 6-phosphofructokinase type A, ATP-PFK, ATP-dependent 6-phosphofructokinase, muscle type, PFK-A, PFK-M, ...
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High impact information on Pfkm

  • These results demonstrate that CAV-1 creates binding sites for PFK and ALD that may be of higher affinity than those binding sites localized in the cytoplasm [1].
  • The localization of aldolase (ALD) was also shifted towards the plasma membrane (and colocalized with PFK) in CAV-1 over-expressing cells [1].
  • We conclude that CAV-1 functions as a scaffolding protein for PFK, ALD and perhaps other glycolytic enzymes, either through direct interaction or accessory proteins, thus contributing to compartmented metabolism in vascular smooth muscle [1].
  • Protein kinase C (PKC)-delta, PKC-gamma, stress-activated protein kinase, cAMP-dependent protein kinase beta isoform, Janus protein kinase, and phosphofructokinase M were all down regulated chronically with citalopram and fluoxetine, but not with acute fluoxetine [2].

Analytical, diagnostic and therapeutic context of Pfkm

  • Confocal immunofluorescence microscopy was used to study the distribution of phosphofructokinase (PFK) and CAV-1 in the transfected cells [1].


  1. Overexpression of caveolin-1 results in increased plasma membrane targeting of glycolytic enzymes: the structural basis for a membrane associated metabolic compartment. Raikar, L.S., Vallejo, J., Lloyd, P.G., Hardin, C.D. J. Cell. Biochem. (2006) [Pubmed]
  2. Antidepressant effects on kinase gene expression patterns in rat brain. Rausch, J.L., Gillespie, C.F., Fei, Y., Hobby, H.M., Stoming, T., Ganapathy, V., Leibach, F.H. Neurosci. Lett. (2002) [Pubmed]
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