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Gene Review:

Muc5ac - mucin 5, subtypes A and C,...

Rattus norvegicus

This record was replaced with 682837.

Ishibashi, Y. et al., Mata, M. et al., Shimizu, T. et al., Lu, W. et al.

Shimizu, Hirano, Shimizu, Kishioka, Sakakura, Majima, Ishibashi, Kobayashi, Idesawa, Taniguchi, Matsuzawa,

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High impact information on Muc5ac

A 2-fold increase in mucin mRNA (rat Muc5ac) expression was induced after LPS instillation or OVA challenge, compared with animals treated with saline instillation (p < 0.05) [1].
Effects of dexamethasone on Muc5ac mucin production by primary airway goblet cells [2].
Effects of carbocisteine on altered activities of glycosidase and glycosyltransferase and expression of Muc5ac in SO2-exposed rats [3].
To investigate the mechanism of carbocisteine action, we evaluated the effects of carbocisteine on the activity of fucosidase, sialidase, fucosyltransferase and sialyltransferase, and on the expression of Muc5ac mRNA in the airway epithelium of SO(2)-exposed rats [3].
These findings suggest that carbocisteine may normalize fucose and sialic acid contents in mucin glycoprotein through regulation of these enzyme activities, and inhibition of both Muc5ac mRNA and protein expressions in SO(2)-exposed rats [3].

Anatomical context of Muc5ac

The numbers of mucus secretory cells in airway epithelium, and the Muc5ac messenger ribonucleic acid and protein expression, were markedly augmented in rats exposed to bleomycin [4].

Analytical, diagnostic and therapeutic context of Muc5ac

The expression levels of Muc5ac mRNA and protein were determined with real-time reverse transcriptase-polymerase chain reaction (real-time RT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively [3].

References

Differential properties of mucous glycoproteins in rat nasal epithelium. A comparison between allergic inflammation and lipopolysaccharide stimulation. Shimizu, T., Hirano, H., Shimizu, S., Kishioka, C., Sakakura, Y., Majima, Y. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
Effects of dexamethasone on Muc5ac mucin production by primary airway goblet cells. Lu, W., Lillehoj, E.P., Kim, K.C. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
Effects of carbocisteine on altered activities of glycosidase and glycosyltransferase and expression of Muc5ac in SO2-exposed rats. Ishibashi, Y., Kobayashi, F., Idesawa, A., Taniguchi, A., Matsuzawa, S. Eur. J. Pharmacol. (2004) [Pubmed]
Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats. Mata, M., Ruíz, A., Cerdá, M., Martinez-Losa, M., Cortijo, J., Santangelo, F., Serrano-Mollar, A., Llombart-Bosch, A., Morcillo, E.J. Eur. Respir. J. (2003) [Pubmed]

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