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Gene Review

St6gal1  -  ST6 beta-galactosamide alpha-2,6...

Rattus norvegicus

Synonyms: Alpha 2,6-ST 1, Beta-galactoside alpha-2,6-sialyltransferase 1, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1, ST6Gal I, ST6GalI, ...
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Disease relevance of St6gal1

  • This was accomplished by using a novel baculovirus vector designed to express a mammalian alpha2,6-sialyltransferase early in infection and a new insect cell line stably transformed to constitutively express a mammalian beta1,4-galactosyltransferase [1].
  • A polyclonal antibody, a bacteriophage-derived endo-neuraminidase, and an Escherichia coli K1 sialyltransferase are all specific for either recognizing or synthesizing poly(sialic acid) containing alpha-2,8-ketosidic linkages [2].
  • Sialyltransferase of the 13762 rat mammary ascites tumor cells [3].
  • In this study the regulation of sialyltransferase expression by dexamethasone in H35 rat hepatoma cells is assessed by Northern hybridization and enzyme activity assays [4].
  • Slices were prepared from control rats and rats suffering from the acute-phase response, where release of sialyltransferase is increased substantially [Lammers & Jamieson (1988) Biochem. J. 256, 623-631; Kaplan, Woloski, Hellman & Jamieson (1983) J. Biol. Chem. 258, 11505-11509] [5].

High impact information on St6gal1


Chemical compound and disease context of St6gal1


Biological context of St6gal1


Anatomical context of St6gal1


Associations of St6gal1 with chemical compounds


Regulatory relationships of St6gal1

  • Rabbit antibodies raised to the Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase inhibit its enzymatic activity greater than 99% but caused little or no inhibition of Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialytransferase [24].

Other interactions of St6gal1


Analytical, diagnostic and therapeutic context of St6gal1


  1. Mammalian glycosyltransferase expression allows sialoglycoprotein production by baculovirus-infected insect cells. Seo, N.S., Hollister, J.R., Jarvis, D.L. Protein Expr. Purif. (2001) [Pubmed]
  2. Use of prokaryotic-derived probes to identify poly(sialic acid) in neonatal neuronal membranes. Vimr, E.R., McCoy, R.D., Vollger, H.F., Wilkison, N.C., Troy, F.A. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  3. Sialyltransferase of the 13762 rat mammary ascites tumor cells. Pratt, T., Sherblom, A.P. Cancer Res. (1984) [Pubmed]
  4. Regulation of beta-galactoside alpha 2,6-sialyltransferase gene expression by dexamethasone. Wang, X.C., O'Hanlon, T.P., Lau, J.T. J. Biol. Chem. (1989) [Pubmed]
  5. Studies on the effect of lysosomotropic agents on the release of Gal beta 1-4GlcNAc alpha-2,6-sialytransferase from rat liver slices during the acute-phase response. Lammers, G., Jamieson, J.C. Biochem. J. (1989) [Pubmed]
  6. Demonstration of an extensive trans-tubular network continuous with the Golgi apparatus stack that may function in glycosylation. Roth, J., Taatjes, D.J., Lucocq, J.M., Weinstein, J., Paulson, J.C. Cell (1985) [Pubmed]
  7. Concomitant elevations in serum sialytransferase activity and sialic acid content in rats with metastasizing mammary tumors. Bernacki, R.J., Kim, U. Science (1977) [Pubmed]
  8. Developmental control of N-CAM sialylation state by Golgi sialyltransferase isoforms. Breen, K.C., Regan, C.M. Development (1988) [Pubmed]
  9. Regulation of expression of beta-galactoside alpha 2,6-sialyltransferase in a rat tumor, Zajdela ascitic hepatoma. Jain, N., Sudhakar, C., Das, M.R. FEBS Lett. (1993) [Pubmed]
  10. Studies of monokines as mediators of the acute phase response: effects on sialyltransferase, albumin, alpha 1-acid glycoprotein and beta-N-acetylhexosaminidase. Woloski, B.M., Gospodarek, E., Jamieson, J.C. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  11. Study of O-glycan sialylation in C6 cultured glioma cells: evidence for post-translational regulation of a beta-galactoside alpha 2,3 sialyltransferase activity by N-glycosylation. Broquet, P., George, P., Geoffroy, J., Reboul, P., Louisot, P. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  12. Comparative study of the levels of sialyltransferases responsible for the formation of sugar chains in glycoproteins and gangliosides in rat liver and hepatomas. Miyagi, T., Koseki, M., Tsuiki, S. Jpn. J. Cancer Res. (1988) [Pubmed]
  13. Tissue-specific alternative splicing of the beta-galactoside alpha 2,6-sialyltransferase gene. Wen, D.X., Svensson, E.C., Paulson, J.C. J. Biol. Chem. (1992) [Pubmed]
  14. Primary structure of beta-galactoside alpha 2,6-sialyltransferase. Conversion of membrane-bound enzyme to soluble forms by cleavage of the NH2-terminal signal anchor. Weinstein, J., Lee, E.U., McEntee, K., Lai, P.H., Paulson, J.C. J. Biol. Chem. (1987) [Pubmed]
  15. Transcriptional regulation of the liver beta-galactoside alpha 2,6-sialyltransferase by glucocorticoids. Wang, X.C., Smith, T.J., Lau, J.T. J. Biol. Chem. (1990) [Pubmed]
  16. Rat beta-galactoside alpha 2,6-sialyltransferase genomic organization: alternate promoters direct the synthesis of liver and kidney transcripts. Wang, X., O'Hanlon, T.P., Young, R.F., Lau, J.T. Glycobiology (1990) [Pubmed]
  17. Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1). Kitazume, S., Tachida, Y., Oka, R., Kotani, N., Ogawa, K., Suzuki, M., Dohmae, N., Takio, K., Saido, T.C., Hashimoto, Y. J. Biol. Chem. (2003) [Pubmed]
  18. Conserved cysteines in the sialyltransferase sialylmotifs form an essential disulfide bond. Datta, A.K., Chammas, R., Paulson, J.C. J. Biol. Chem. (2001) [Pubmed]
  19. Analytical study of microsomes and isolated subcellular membranes from rat liver. VII. Distribution of protein-bound sialic acid. Amar-Costesec, A. J. Cell Biol. (1981) [Pubmed]
  20. Membrane markers of endoplasmic reticulum preserved in autophagic vacuolar membranes isolated from leupeptin-administered rat liver. Ueno, T., Muno, D., Kominami, E. J. Biol. Chem. (1991) [Pubmed]
  21. Post-Golgi apparatus localization and regional expression of rat intestinal sialyltransferase detected by immunoelectron microscopy with polypeptide epitope-purified antibody. Taatjes, D.J., Roth, J., Weinstein, J., Paulson, J.C. J. Biol. Chem. (1988) [Pubmed]
  22. Tissue-specific expression of beta-galactoside alpha-2,6-sialyltransferase. Transcript heterogeneity predicts a divergent polypeptide. O'Hanlon, T.P., Lau, K.M., Wang, X.C., Lau, J.T. J. Biol. Chem. (1989) [Pubmed]
  23. Orientation of glycoprotein galactosyltransferase and sialyltransferase enzymes in vesicles derived from rat liver Golgi apparatus. Fleischer, B. J. Cell Biol. (1981) [Pubmed]
  24. Purification of a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase and a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase to homogeneity from rat liver. Weinstein, J., de Souza-e-Silva, U., Paulson, J.C. J. Biol. Chem. (1982) [Pubmed]
  25. Effects of carbocisteine on altered activities of glycosidase and glycosyltransferase and expression of Muc5ac in SO2-exposed rats. Ishibashi, Y., Kobayashi, F., Idesawa, A., Taniguchi, A., Matsuzawa, S. Eur. J. Pharmacol. (2004) [Pubmed]
  26. The role of a cathepsin D-like activity in the release of Gal beta 1-4GlcNAc alpha 2-6-sialyltransferase from rat liver Golgi membranes during the acute-phase response. Lammers, G., Jamieson, J.C. Biochem. J. (1988) [Pubmed]
  27. The metabolism of sialic acids in isolated rat colonic mucosal cells. Corfield, A.P., Clamp, J.R., Wagner, S.A. Biochem. J. (1985) [Pubmed]
  28. Correlation of serum, tumor, and liver serum glycoprotein: N-acetylneuraminic acid transferase activity with growth of the R3230AC mammary tumor in rats and relationship of the serum activity to tumor burden. Evans, I.M., Hilf, R., Murphy, M., Bosmann, H.B. Cancer Res. (1980) [Pubmed]
  29. Polymerase chain reaction cloning of a developmentally regulated member of the sialyltransferase gene family. Livingston, B.D., Paulson, J.C. J. Biol. Chem. (1993) [Pubmed]
  30. The signal anchor and stem regions of the beta-galactoside alpha 2,6-sialyltransferase may each act to localize the enzyme to the Golgi apparatus. Colley, K.J., Lee, E.U., Paulson, J.C. J. Biol. Chem. (1992) [Pubmed]
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