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Gene Review

Fut1  -  fucosyltransferase 1

Rattus norvegicus

Synonyms: Alpha 1,2-fucosyltransferase A, Alpha(1,2)FT 1, Fta, Fucosyltransferase 1, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1, ...
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Disease relevance of Fut1


Psychiatry related information on Fut1


High impact information on Fut1

  • This difference in the level of fucosyltransferase B was not caused either by differential hydrolysis of GDP-fucose by pyrophosphatase in the 2 groups or by hydrolysis of the product by fucosidases [1].
  • The enzyme that transfers fucose to the first acceptor was designated fucosyltransferase A, whereas the one that uses the second acceptor was designated fucosyltransferase B. Both types of fucosyltransferases were found in this rat mammary tumor system [1].
  • Fucosyltransferase levels in 6 established strains of spontaneously metastasizing rat mammary tumors (STMT-058, MT-449, DMBA-4, SMT-077, TMT-081, and SMT-2A) were compared with 4 nonmetastasizing strains (MT-W9B, MT-W9A, MT-100, and MT-66) as controls [1].
  • A GDP-fucose:GM1 alpha1-->2 fucosyltransferase (FucT) is induced during early stages of chemical hepatocarcinogenesis in parenchymal cells of Fischer 344 rats fed a diet supplemented with 0.03% N-2-acetylaminofluorene (AAF) [5].
  • Here, we describe the use of the soluble, recombinant alpha2-3 sialyltransferase ST3Gal-III and the alpha1-3 fucosyltransferase FT-VI in vitro to introduce sLe(x) moieties onto the N-glycan chains of sCR1 overexpressed in standard CHO cell lines [6].

Chemical compound and disease context of Fut1


Biological context of Fut1


Anatomical context of Fut1


Associations of Fut1 with chemical compounds


Other interactions of Fut1

  • (1) Only 10-20% of the total glycosyltransferase activities (sialyltransferase, fucosyltransferase, galactosyltransferase, and N-acetyl glucosaminyltransferase) sedimented with the spermatozoa; the remaining 80-90% of the four enzymes were present in soluble form in the epididymal fluid [12].

Analytical, diagnostic and therapeutic context of Fut1

  • The M(r) values determined by SDS-PAGE electrophoresis of alpha-1,3/4 fucosyltransferase and of alpha-1,3 fucosyltransferase were 68,780 and 40,680 respectively [16].


  1. Fucosyltransferase activity in metastasizing and nonmetastasizing rat mammary carcinomas. Chatterjee, S.K., Kim, U. J. Natl. Cancer Inst. (1978) [Pubmed]
  2. Gene expression of alpha1-6 fucosyltransferase in human hepatoma tissues: a possible implication for increased fucosylation of alpha-fetoprotein. Noda, K., Miyoshi, E., Uozumi, N., Yanagidani, S., Ikeda, Y., Gao, C., Suzuki, K., Yoshihara, H., Yoshikawa, K., Kawano, K., Hayashi, N., Hori, M., Taniguchi, N., Yoshikawa, M. Hepatology (1998) [Pubmed]
  3. Enzymic synthesis of a new type of fucose-containing glycolipid with fucosyltransferase of rat ascites hepatoma cell, AH 7974F. Taki, T., Hirabayashi, Y., Matsumoto, M., Kojima, K. Biochim. Biophys. Acta (1979) [Pubmed]
  4. Role of insulin and nutritional factors in intestinal glycoprotein fucosylation during postnatal development. Biol, M.C., Lenoir, D., Greco, S., Galvain, D., Hugueny, I., Louisot, P. Am. J. Physiol. (1998) [Pubmed]
  5. An amino acid region at the N-terminus of rat hepatoma alpha1-->2 fucosyltransferase modulates enzyme activity and interaction with lipids: strong preference for glycosphingolipids containing terminal Galbeta1-->3GalNAc-structures. Sherwood, A.L., Stroud, M.R., Levery, S.B., Holmes, E.H. Biochemistry (2001) [Pubmed]
  6. Production of a complement inhibitor possessing sialyl Lewis X moieties by in vitro glycosylation technology. Thomas, L.J., Panneerselvam, K., Beattie, D.T., Picard, M.D., Xu, B., Rittershaus, C.W., Marsh, H.C., Hammond, R.A., Qian, J., Stevenson, T., Zopf, D., Bayer, R.J. Glycobiology (2004) [Pubmed]
  7. The chemical carcinogen-induced enzyme, GDP-fucose: GM1 alpha 1----2 fucosyltransferase in rat liver and hepatoma: modulation by and association with phospholipids. Holmes, E.H., Hakomori, S. J. Biochem. (1987) [Pubmed]
  8. Biosynthesis of a blood group H1 antigen by alpha 1, 2-fucosyltransferase in PC12 cells. Kojima, H., Nakamura, K., Mineta-Kitajima, R., Sone, Y., Tamai, Y. Glycoconj. J. (1996) [Pubmed]
  9. Increase of rat colon carcinoma cells tumorigenicity by alpha(1-2) fucosyltransferase gene transfection. Goupille, C., Hallouin, F., Meflah, K., Le Pendu, J. Glycobiology (1997) [Pubmed]
  10. Surface-associated glycosyltransferase activities in rat Sertoli cells in vitro. Raychoudhury, S.S., Millette, C.F. Mol. Reprod. Dev. (1993) [Pubmed]
  11. Retinoic acid modulation of alpha(1-->2) fucosyltransferase activity and sensitivity of tumor cells to LAK-mediated cytotoxicity. Labarrière, N., Piau, J.P., Zennadi, R., Blanchardie, P., Denis, M., Lustenberger, P. In Vitro Cell. Dev. Biol. (1993) [Pubmed]
  12. Glycosylation of rat sperm plasma membrane during epididymal maturation. Tulsiani, D.R., Skudlarek, M.D., Holland, M.K., Orgebin-Crist, M.C. Biol. Reprod. (1993) [Pubmed]
  13. Effect of dietary fiber at weaning on protein glycosylation in the rat small intestine. Tardy, F., Louisot, P., Martin, A. Int. J. Biochem. Cell Biol. (1995) [Pubmed]
  14. Occurrence of two fucosyltransferase activities at the outer surface of rat lymphocytes. Hoflack, B., Cacan, R., Verbert, A. Eur. J. Biochem. (1978) [Pubmed]
  15. Changes in activities of fucokinase and fucosyltransferase in rat hippocampus after acquisition of a brightness discrimination reaction. Popov, N., Schmidt, S., Schulzeck, S., Jork, R., Lössner, B., Matthies, H. Pharmacol. Biochem. Behav. (1983) [Pubmed]
  16. Characterization and purification of fucosyltransferases from the cytosol of rat colon. Karaivanova, V., Mookerjea, S., Hunt, D., Nagpurkar, A. Int. J. Biochem. Cell Biol. (1996) [Pubmed]
  17. Glycosidic specificity of fucosyltransferases present in rat epididymal spermatozoa. Raychoudhury, S.S., Millette, C.F. J. Androl. (1995) [Pubmed]
  18. Mechanisms of dopamine induced changes in hippocampal glycoprotein metabolism. Jork, R., Schmidt, S., Schulzeck, S., Lössner, B., Popov, N., Matthies, H. Pharmacol. Biochem. Behav. (1982) [Pubmed]
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