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Gene Review

WNK2  -  WNK lysine deficient protein kinase 2

Homo sapiens

Synonyms: Antigen NY-CO-43, KIAA1760, NY-CO-43, P/OKcl.13, PRKWNK2, ...
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Disease relevance of WNK2


High impact information on WNK2


Regulatory relationships of WNK2

  • Together, these results provide evidence that WNK2 is involved in the modulation of growth factor-induced cancer cell proliferation through the MEK1/ERK1/2 pathway [3].


  1. Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific. Jun, P., Hong, C., Lal, A., Wong, J.M., McDermott, M.W., Bollen, A.W., Plass, C., Held, W.A., Smiraglia, D.J., Costello, J.F. Neuro-oncology (2009) [Pubmed]
  2. Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3). Holden, S., Cox, J., Raymond, F.L. Gene (2004) [Pubmed]
  3. Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. Moniz, S., Veríssimo, F., Matos, P., Brazão, R., Silva, E., Kotelevets, L., Kotevelets, L., Chastre, E., Gespach, C., Jordan, P. Oncogene (2007) [Pubmed]
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