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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SNAPC3  -  small nuclear RNA activating complex,...

Homo sapiens

Synonyms: MGC132011, MGC33124, PSE-binding factor subunit beta, PTF subunit beta, PTFbeta, ...
 
 
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Disease relevance of SNAPC3

  • Previous studies have shown that a partial SNAP(C) composed of SNAP190 (1-514), SNAP50, and SNAP43 expressed in baculovirus is capable of PSE-specific DNA binding and transcription of human snRNA genes by RNA polymerases II and III [1].
 

High impact information on SNAPC3

  • Depletions with anti-SNAP50 antibodies inhibit RNA polymerase II and III snRNA gene transcription in vitro [2].
  • RB also interacts with two SNAP(c) subunits, SNAP43 and SNAP50 [3].
  • The data presented herein shows that SNAP50 plays an important role in DNA binding by SNAP(C) through its zinc finger domain [4].
  • The SNAP50 zinc finger domain contains 15 cysteine and histidine residues configured in two potential zinc coordination arrangements [4].
  • Since p57 and its T.brucei counterpart are homologous to SNAP50, a component of the human small nuclear RNA gene activation protein complex (SNAPc), both SLRNA and RRNA transcription in T.brucei may depend on a SNAPc-like transcription factor [5].
 

Other interactions of SNAPC3

  • DNA binding by SNAP(C) involves direct DNA contacts by the SNAP190 subunit in cooperation with SNAP50 and SNAP43 [4].

References

  1. Co-expression of multiple subunits enables recombinant SNAPC assembly and function for transcription by human RNA polymerases II and III. Hanzlowsky, A., Jelencic, B., Jawdekar, G., Hinkley, C.S., Geiger, J.H., Henry, R.W. Protein Expr. Purif. (2006) [Pubmed]
  2. Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc. Henry, R.W., Ma, B., Sadowski, C.L., Kobayashi, R., Hernandez, N. EMBO J. (1996) [Pubmed]
  3. The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression. Hirsch, H.A., Gu, L., Henry, R.W. Mol. Cell. Biol. (2000) [Pubmed]
  4. The Unorthodox SNAP50 Zinc Finger Domain Contributes to Cooperative Promoter Recognition by Human SNAPC. Jawdekar, G.W., Hanzlowsky, A., Hovde, S.L., Jelencic, B., Feig, M., Geiger, J.H., Henry, R.W. J. Biol. Chem. (2006) [Pubmed]
  5. The Trypanosoma brucei spliced leader RNA and rRNA gene promoters have interchangeable TbSNAP50-binding elements. Schimanski, B., Laufer, G., Gontcharova, L., Günzl, A. Nucleic Acids Res. (2004) [Pubmed]
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