The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

Table of contents

About

Terms

 

Gene Review: 

SNAPC4  -  small nuclear RNA activating complex,...

Homo sapiens

Synonyms: FLJ13451, PSE-binding factor subunit alpha, PTF subunit alpha, PTFalpha, Proximal sequence element-binding transcription factor subunit alpha, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of SNAPC4

  • Previous studies have shown that a partial SNAP(C) composed of SNAP190 (1-514), SNAP50, and SNAP43 expressed in baculovirus is capable of PSE-specific DNA binding and transcription of human snRNA genes by RNA polymerases II and III [1].
 

High impact information on SNAPC4

  • Structural analysis of the Oct-1 POU domain/U1 octamer/SNAP190 peptide complex revealed that SNAP190 makes extensive protein contacts with the Oct-1 POU-specific domain and with the DNA phosphate backbone within the enhancer [2].
  • This SNAP190 region is strikingly similar to a region in the B-cell-specific Oct-1 coactivator, OBF-1, that is required for interaction with octamer-bound Oct-1 POU domain [3].
  • By generating complexes smaller than mini-SNAP(c), we have identified a 50-amino-acid region within SNAP190 that is (i) required for cooperative binding with TBP in the context of mini-SNAP(c) and (ii) sufficient for cooperative binding with TBP when fused to a heterologous DNA binding domain [4].
  • In addition, SNAP190 interacts with Oct-1 [5].
  • SNAP190 is required for snRNA gene transcription by both RNA polymerases II and III and interacts with SNAP45 [5].
 

Biological context of SNAPC4

  • Truncated SNAP190 containing only the Myb DNA binding domain is sufficient for TBP recruitment to the TATA box [6].
 

Anatomical context of SNAPC4

  • We previously have shown that PTF purified from human HeLa cells is a multisubunit complex of four polypeptides designated PTF alpha, -beta, -gamma, and -delta [7].
 

Associations of SNAPC4 with chemical compounds

 

Regulatory relationships of SNAPC4

  • Therefore, the SNAP190 Myb domain functions both to specifically recognize the proximal sequence element present in the core promoters of human snRNA genes and to stimulate TBP recognition of the neighboring TATA box present in human U6 snRNA promoters [6].
 

Other interactions of SNAPC4

  • The SNAP190 Myb domain also stimulates complex assembly with TBP and Brf2, a subunit of a snRNA-specific TFIIIB complex [6].
 

Analytical, diagnostic and therapeutic context of SNAPC4

References

  1. Co-expression of multiple subunits enables recombinant SNAPC assembly and function for transcription by human RNA polymerases II and III. Hanzlowsky, A., Jelencic, B., Jawdekar, G., Hinkley, C.S., Geiger, J.H., Henry, R.W. Protein Expr. Purif. (2006) [Pubmed]
  2. Activator recruitment by the general transcription machinery: X-ray structural analysis of the Oct-1 POU domain/human U1 octamer/SNAP190 peptide ternary complex. Hovde, S., Hinkley, C.S., Strong, K., Brooks, A., Gu, L., Henry, R.W., Geiger, J. Genes Dev. (2002) [Pubmed]
  3. The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAPc largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1. Ford, E., Strubin, M., Hernandez, N. Genes Dev. (1998) [Pubmed]
  4. Redundant cooperative interactions for assembly of a human U6 transcription initiation complex. Ma, B., Hernandez, N. Mol. Cell. Biol. (2002) [Pubmed]
  5. The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1. Wong, M.W., Henry, R.W., Ma, B., Kobayashi, R., Klages, N., Matthias, P., Strubin, M., Hernandez, N. Mol. Cell. Biol. (1998) [Pubmed]
  6. The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. Hinkley, C.S., Hirsch, H.A., Gu, L., LaMere, B., Henry, R.W. J. Biol. Chem. (2003) [Pubmed]
  7. Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein. Yoon, J.B., Roeder, R.G. Mol. Cell. Biol. (1996) [Pubmed]
  8. Crystallization of the Oct-1/SNAP190 peptide/DNA complex. Hovde, S., Brooks, A., Strong, K., Geiger, J.H. Acta Crystallogr. D Biol. Crystallogr. (2002) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities