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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SNAPC1  -  small nuclear RNA activating complex,...

Homo sapiens

Synonyms: PSE-binding factor subunit gamma, PTF subunit gamma, PTFgamma, Proximal sequence element-binding transcription factor subunit gamma, SNAP43, ...
 
 
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Disease relevance of SNAPC1

  • Previous studies have shown that a partial SNAP(C) composed of SNAP190 (1-514), SNAP50, and SNAP43 expressed in baculovirus is capable of PSE-specific DNA binding and transcription of human snRNA genes by RNA polymerases II and III [1].
  • SNAP43, a subunit of the TBP-TAF complex, was expressed 20-fold higher in MDA-MB-231 compared to MCF12A and several breast cancer cell lines, implying that SNAP43 may be involved in tumorigenesis of a specific subset of breast cancers [2].
 

High impact information on SNAPC1

  • The predicted amino-acid sequence of SNAP43 reveals that it corresponds to a new protein [3].
  • RB also interacts with two SNAP(c) subunits, SNAP43 and SNAP50 [4].
  • We now report the isolation and expression of cDNAs encoding PTF gamma and PTF delta, as well as functional studies with cognate antibodies that recognize the native PTF complex in HeLa extracts [5].
  • Immunoprecipitation assays also show a weak substoichiometric association of the TATA-binding protein (TBP) with PTF, consistent with the previous report of a PTF-related complex (SNAPc) containing substoichiometric levels of TBP and a component (SNAPc43) identical in sequence to the PTF gamma reported here [5].
  • However, genetic alterations of MDA-MB-231 included a deletion of chromosome 14 with a reciprocal translocation t(6;14) and two additional translocations [t(12;14) and t(14;15)] as determined by fluorescent in situ hybridization (FISH) with YAC 823G8 located at chromosome 14q23 which contained SNAP43 [2].
 

Biological context of SNAPC1

 

Physical interactions of SNAPC1

 

Analytical, diagnostic and therapeutic context of SNAPC1

  • We previously reported the purification of human PTF, a complex of four subunits, and the molecular cloning and characterization of PTF gamma and delta subunits [9].

References

  1. Co-expression of multiple subunits enables recombinant SNAPC assembly and function for transcription by human RNA polymerases II and III. Hanzlowsky, A., Jelencic, B., Jawdekar, G., Hinkley, C.S., Geiger, J.H., Henry, R.W. Protein Expr. Purif. (2006) [Pubmed]
  2. Discovery of over-expressed genes and genetic alterations in breast cancer cells using a combination of suppression subtractive hybridization, multiplex FISH and comparative genomic hybridization. Xie, D., Jauch, A., Miller, C.W., Bartram, C.R., Koeffler, H.P. Int. J. Oncol. (2002) [Pubmed]
  3. A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III. Henry, R.W., Sadowski, C.L., Kobayashi, R., Hernandez, N. Nature (1995) [Pubmed]
  4. The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression. Hirsch, H.A., Gu, L., Henry, R.W. Mol. Cell. Biol. (2000) [Pubmed]
  5. Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein. Yoon, J.B., Roeder, R.G. Mol. Cell. Biol. (1996) [Pubmed]
  6. The Unorthodox SNAP50 Zinc Finger Domain Contributes to Cooperative Promoter Recognition by Human SNAPC. Jawdekar, G.W., Hanzlowsky, A., Hovde, S.L., Jelencic, B., Feig, M., Geiger, J.H., Henry, R.W. J. Biol. Chem. (2006) [Pubmed]
  7. The human PTFgamma/SNAP43 gene: structure, chromosomal location, and identification of a VNTR in 5'-UTR. Maeng, J.H., Yoon, J.B. J. Biochem. (1998) [Pubmed]
  8. Cooperation between small nuclear RNA-activating protein complex (SNAPC) and TATA-box-binding protein antagonizes protein kinase CK2 inhibition of DNA binding by SNAPC. Gu, L., Esselman, W.J., Henry, R.W. J. Biol. Chem. (2005) [Pubmed]
  9. Cloning and characterization of the beta subunit of human proximal sequence element-binding transcription factor and its involvement in transcription of small nuclear RNA genes by RNA polymerases II and III. Bai, L., Wang, Z., Yoon, J.B., Roeder, R.G. Mol. Cell. Biol. (1996) [Pubmed]
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