Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Hamp2 - hepcidin antimicrobial peptide 2

Mus musculus

Synonyms: 1810073K19Rik, HEPC2, Hepc2, Hepcidin-2

Lou, D.Q. et al., Krijt, J. et al., Courselaud, B. et al.

Krijt, Cmejla, Sýkora, Vokurka, Vyoral, Necas,

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High impact information on Hamp2

These data provide evidence that hepc2 does not act on iron metabolism like hepc1 and give clues for the identification of amino acids important for the iron-regulatory action of the mature 25-amino acid peptide [1].
Hepc2 transgenic mRNA level was found to be very high for all lines compared with the level of hepc1 transgene mRNA necessary to produce severe anemia [1].

Biological context of Hamp2

Specific hepatic Hepc1 and Hepc2 mRNA levels were quantified using real-time reverse transcription polymerase chain reaction (RT-PCR) [2].
In contrast to the human genome, which contains only one copy of the gene, the mouse genome contains 2 highly similar hepcidin genes, hepc1 and hepc2, which are, however, considerably divergent at the level of the corresponding mature 25-amino acid peptide [1].

Other interactions of Hamp2

The aim of this study was to examine possible differences in the expression of hepcidin genes (Hamp and Hamp2) between the two strains [3].

References

Functional differences between hepcidin 1 and 2 in transgenic mice. Lou, D.Q., Nicolas, G., Lesbordes, J.C., Viatte, L., Grimber, G., Szajnert, M.F., Kahn, A., Vaulont, S. Blood (2004) [Pubmed]
Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice. Courselaud, B., Troadec, M.B., Fruchon, S., Ilyin, G., Borot, N., Leroyer, P., Coppin, H., Brissot, P., Roth, M.P., Loréal, O. Blood Cells Mol. Dis. (2004) [Pubmed]
Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice. Krijt, J., Cmejla, R., Sýkora, V., Vokurka, M., Vyoral, D., Necas, E. J. Hepatol. (2004) [Pubmed]

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