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Gene Review

Hamp  -  hepcidin antimicrobial peptide

Mus musculus

Synonyms: HEPC1, Hamp1, Hepc, Hepc1, Hepcidin
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Disease relevance of Hamp1


High impact information on Hamp1

  • Mice with deficiencies in the hemochromatosis gene product, Hfe, mounted a general inflammatory response after injection of lipopolysaccharide but lacked appropriate Hamp expression and did not develop hyposideremia [3].
  • Confirming our prior results, Hepc1(-/-) mice developed early and severe multivisceral iron overload, with sparing of the spleen macrophages, and demonstrated increased serum iron and ferritin levels as compared with their controls [5].
  • These data provide evidence that hepc2 does not act on iron metabolism like hepc1 and give clues for the identification of amino acids important for the iron-regulatory action of the mature 25-amino acid peptide [6].
  • We recently described the severe iron-deficient anemia phenotype in transgenic mice overexpressing hepc1 in the liver [6].
  • Hamp regulation due to iron did not appear dependent on transcription-level changes of the murine homolog of Hemojuvelin (Rgmc) [2].

Chemical compound and disease context of Hamp1


Biological context of Hamp1


Associations of Hamp1 with chemical compounds


Other interactions of Hamp1

  • The aim of this study was to examine possible differences in the expression of hepcidin genes (Hamp and Hamp2) between the two strains [8].
  • Insertion of a retroviral intracisternal A-particle element was found upstream of the HEPC1 gene [9].


  1. Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload. Bondi, A., Valentino, P., Daraio, F., Porporato, P., Gramaglia, E., Carturan, S., Gottardi, E., Camaschella, C., Roetto, A. Haematologica (2005) [Pubmed]
  2. The molecular circuitry regulating the switch between iron deficiency and overload in mice. Mok, H., Mlodnicka, A.E., Hentze, M.W., Muckenthaler, M., Schumacher, A. J. Biol. Chem. (2006) [Pubmed]
  3. An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Roy, C.N., Custodio, A.O., de Graaf, J., Schneider, S., Akpan, I., Montross, L.K., Sanchez, M., Gaudino, A., Hentze, M.W., Andrews, N.C., Muckenthaler, M.U. Nat. Genet. (2004) [Pubmed]
  4. Exploring the Role of Hepcidin, an Antimicrobial and Iron Regulatory Peptide, in Increased Iron Absorption in {beta}-Thalassemia. Breda, L., Gardenghi, S., Guy, E., Rachmilewitz, E.A., Weizer-Stern, O., Adamsky, K., Amariglio, N., Rechavi, G., Giardina, P.J., Grady, R.W., Rivella, S. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
  5. Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Lesbordes-Brion, J.C., Viatte, L., Bennoun, M., Lou, D.Q., Ramey, G., Houbron, C., Hamard, G., Kahn, A., Vaulont, S. Blood (2006) [Pubmed]
  6. Functional differences between hepcidin 1 and 2 in transgenic mice. Lou, D.Q., Nicolas, G., Lesbordes, J.C., Viatte, L., Grimber, G., Szajnert, M.F., Kahn, A., Vaulont, S. Blood (2004) [Pubmed]
  7. Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice. Courselaud, B., Troadec, M.B., Fruchon, S., Ilyin, G., Borot, N., Leroyer, P., Coppin, H., Brissot, P., Roth, M.P., Loréal, O. Blood Cells Mol. Dis. (2004) [Pubmed]
  8. Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice. Krijt, J., Cmejla, R., Sýkora, V., Vokurka, M., Vyoral, D., Necas, E. J. Hepatol. (2004) [Pubmed]
  9. Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload. Ilyin, G., Courselaud, B., Troadec, M.B., Pigeon, C., Alizadeh, M., Leroyer, P., Brissot, P., Loréal, O. FEBS Lett. (2003) [Pubmed]
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