Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Fgf22 - fibroblast growth factor 22

Mus musculus

Synonyms: 2210414E06Rik, FGF-22, Fibroblast growth factor 22

Umemori, H. et al., Katoh, Y. et al., Beyer, T.A. et al.

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High impact information on Fgf22

FGF7 and FGF10, the closest relatives of FGF22, share this activity; other FGFs have distinct effects [1].
Using clustering of synaptic vesicles in cultured neurons as an assay, we purified putative target-derived presynaptic organizing molecules from mouse brain and identified FGF22 as a major active species [1].
In situ hybridization revealed the presence of FGF-22 mRNA throughout the epidermis and hair follicle keratinocytes of E16.5 embryos, as well as in adult skin and keratinocytes of the hyperthickened wound epithelium [2].
Comparative genomics on FGF7, FGF10, FGF22 orthologs, and identification of fgf25 [3].
FGF22 mRNA was expressed in hippocampus and ovarian fibrotheoma [3].

Biological context of Fgf22

FGF10-MRPS30-HCN1 locus at human chromosome 5p12 and FGF22-POLRMT-HCN2 locus at 19p13.3 were paralogous regions within the human genome [3].

References

FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. Umemori, H., Linhoff, M.W., Ornitz, D.M., Sanes, J.R. Cell (2004) [Pubmed]
Fibroblast growth factor 22 and its potential role during skin development and repair. Beyer, T.A., Werner, S., Dickson, C., Grose, R. Exp. Cell Res. (2003) [Pubmed]
Comparative genomics on FGF7, FGF10, FGF22 orthologs, and identification of fgf25. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]

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